A5102877517- Toxin Mechanisms and Immunotoxins
- Bacteriophages and microbial interactions
- Veterinary medicine and infectious diseases
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Transgenic Plants and Applications
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Toxoplasma gondii Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Fungal Infections and Studies
- Monoclonal and Polyclonal Antibodies Research
- Insect and Pesticide Research
- Cancer, Lipids, and Metabolism
- Microbial infections and disease research
Instituto de Investigación Sanitaria Aragón
2019-2022
Universidad de Zaragoza
2019-2022
Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to emergence of resistance mechanisms tumor employs when subjected monomolecular treatments. This review illustrates how dysregulation lipid metabolic pathway constitutes survival strategy adopted by...
Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes tumors. Previous work demonstrated therapeutic effect intratumoral injection recombinant granulysin using vivo models breast cancer multiple myeloma. In we have developed gene fusion to anti-carcinoembryonic antigen (CEA/CEACAM5) single chain Fv antibody fragment MFE23. Both granulysin-based immunotoxin were expressed Pichia pastoris....
9-kDa granulysin is a protein expressed into the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. It has been shown to exert cytolysis on microbes tumors. We showed previously that exerted cell death by apoptosis in vitro hematological tumor lines also cells from B-cell chronic lymphocytic leukemia (B-CLL) patients. In addition, we have anti-tumor efficiency as single agent two vivo models development athymic mice, MDA-MB-231 mammary adenocarcinoma NCI-H929...
Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes tumors. Previous work demonstrated therapeutic effect intratumoral injection recombinant granulysin systemic an immunotoxin between anti-carcinoembryonic antigen single-chain Fv antibody fragment MFE23, which were produced yeast Pichia pastoris. In work, we developed second combining anti-Tn SM3, that could have broader application...
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of SM3 mAb (SM3GRNLY) and other AR20.5 (AR20.5GRNLY). These recognize different amino acid sequences aberrantly O-glycosylated MUC1, also known as Tn antigen, expressed in a variety tumor cell types. We first demonstrated affinity these for their antigen using surface plasmon resonance purified flow cytometry on living cells. The induction death lines origin positive expression was stronger cases than that...
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of SM3 mAb (SM3GRNLY) and other AR20.5 (AR20.5GRNLY). These recognize different amino acid sequences aberrantly O-glycosilated MUC1, also known as Tn antigen, expressed in a variety tumor cell types. We first demonstrated affinity these for their antigen using surface plasmon resonance purified flow cytometry on living cells. The induction death lines origin positive expression was stronger cases than that...
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of SM3 mAb (SM3GRNLY) and other AR20.5 (AR20.5GRNLY). These recognize different amino acid sequences aberrantly O-glycosilated MUC1, also known as Tn antigen, expressed in a variety tumor cell types. We first demonstrated affinity these for their antigen using surface plasmon resonance purified flow cytometry on living cells. The induction death lines origin positive expression was stronger cases than that...
Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological function elimination bacteria parasites. In previous studies our group, anti-tumor capacity recombinant was demonstrated, both in vitro vivo. present work, we developed lipid nanoparticles surfaces can bind through formation complex coordination between histidine tail Ni2+ provided chelating liposome composition termed them...