A5067184581- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and exercise physiology
- Mechanical Circulatory Support Devices
- Mitochondrial Function and Pathology
- Non-Invasive Vital Sign Monitoring
- Cardiomyopathy and Myosin Studies
- Probabilistic and Robust Engineering Design
- ATP Synthase and ATPases Research
- Cardiovascular Health and Disease Prevention
- Stress Responses and Cortisol
- Pulmonary Hypertension Research and Treatments
- Model Reduction and Neural Networks
- Metabolism and Genetic Disorders
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Fluid Dynamics and Turbulent Flows
- Biochemical effects in animals
- Computational Fluid Dynamics and Aerodynamics
University of Michigan
2020-2023
North Carolina State University
2016-2021
Abstract To phenotype mechanistic differences between heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction, a closed‐loop model of the cardiovascular system coupled patient‐specific transthoracic echocardiography (TTE) right catheterization (RHC) data was used to identify key parameters representing haemodynamics. Thirty‐one patient records (10 HFrEF, 21 HFpEF) were obtained from Cardiovascular Health Improvement Project database at University Michigan. Model...
The Valsalva maneuver (VM) is a diagnostic protocol examining sympathetic and parasympathetic activity in patients with autonomic dysfunction (AD) impacting cardiovascular control. Because direct measurement of these signals costly invasive, AD typically assessed indirectly by analyzing heart rate blood pressure response patterns. This study introduces mathematical model that can predict dynamics. Our model-based analysis includes two control mechanisms: respiratory sinus arrhythmia (RSA)...
Introduction: The left (LV) and right (RV) ventricles are linked biologically, hemodynamically, mechanically, a phenomenon known as ventricular interdependence. While LV function has long been to impact RV function, the reverse is increasingly being realized have clinical importance. Investigating interdependence clinically challenging given invasive measurements required, including biventricular catheterization, confounding factors such comorbidities, volume status, other aspects of subject...
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying pathophysiology this model, we analyzed dynamic baroreflex response to spontaneous fluctuations in arterial pressure conscious SHRs, as well Wistar-Kyoto (WKY), Dahl salt-sensitive, salt-resistant, and Sprague-Dawley rat. Observations revealed existence long intermittent periods (lasting up several minutes)...
Abstract To determine the underlying mechanistic differences between diagnoses of Heart Failure (HF) and specifically heart failure with reduced preserved ejection fraction (HFrEF & HFpEF), a closed loop model cardiovascular system coupled patient specific transthoracic echocardiography (TTE) right catheterization (RHC) measures was used to identify key parameters representing hemodynamics. Thirty-one records (10 HFrEF, 21 HFpEF) were obtained from Cardiovascular Health Improvement...
A model-based approach was developed to elucidate etiological differences between and within patient groups representing the two dominant heart failure diagnoses: with reduced (HFrEF) preserved (HFpEF) ejection fraction. closed-loop model of cardiovascular system informed by patient-specific transthoracic echocardiography (TTE) right catheterization (RHC) data used identify key parameters mechanics hemodynamics. Thirty-one records (10 HFrEF, 21 HFpEF) were obtained from Cardiovascular Health...