A5060338278- Arsenic contamination and mitigation
- Mine drainage and remediation techniques
- Biochemical and Molecular Research
- Heavy metals in environment
- Microbial Metabolic Engineering and Bioproduction
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Nanocluster Synthesis and Applications
- Biotin and Related Studies
- Nanoparticles: synthesis and applications
- Enzyme Production and Characterization
- Iron oxide chemistry and applications
- Enzyme Catalysis and Immobilization
- Bacterial biofilms and quorum sensing
University of Edinburgh
2021-2025
Kyushu University
2017-2019
Microbial metabolism is a diverse and sustainable source of synthetic reagents that can be programmed for controlled high-level production via biology. However, despite the chemical diversity metabolism, utility metabolites, available tools to control metabolic chemistry, there remain few examples use cellular metabolites directly synthesis. Herein, we report bacteria perform P=S bond formation (Ph3P Ph3PS) central sulfur nonenzymatic chemistry in vivo, which also applied affect microbial...
Microorganisms produce metal nanoparticles (MNPs) upon exposure to toxic ions. However, the catalytic activity of biosynthesised MNPs remains underexplored, despite potential these biological processes be used for sustainable recovery critical metals, including palladium. Herein we report that biogenic palladium generated by sulfate-reducing bacterium Desulfovibrio alaskensis G20 catalyse ligand-free Suzuki Miyaura reaction abiotic substrates. The is highly efficient (>99% yield, 0.5 mol%...
With the aim to effectively oxidize and remove highly toxic As(III) from acidic metal-refinery wastewaters, seeding effect of different heterogeneous minerals was investigated on formation biogenic scorodite (FeAsO4·2H2O), using Fe2+/As(III)-oxidizing thermo-acidophilic archaeon Acidianus brierleyi. Heterogeneous hematite-seeds exhibited even greater As-removal efficiency relative homogeneous scorodite-seeds. While magnetite-seeds mostly comparable scorodite-seeds, feeding goethite or...
Transition-metal nanoparticles produced by living bacteria are emerging as novel catalysts for sustainable synthesis. However, the scope of their catalytic activity and ability to be integrated within metabolic pathways bioproduction non-natural small molecules has been underexplored. Herein we report that Pd synthesized sulfate-reducing bacterium Desulfovibrio alaskensis G20 (DaPdNPs) catalyze Sonogashira coupling phenyl acetylenes aryl iodides, subsequent one-pot hydrogenation bibenzyl...
The potential utility of mesophilic/moderately thermophilic acidophiles was investigated for immobilization arsenic (As) as scorodite (FeAsO 4 ·2H 2 O) at moderate temperatures (35–45 °C). Here, the acid-tolerant mesophile Thiomonas cuprina Hö5 and acidophilic moderately thermophile Acidimicrobium ferrooxidans ICP were selected As (III)- Fe (II)- oxidizers, respectively. Due to a difference in their optimal growth pHs, 2-step reaction consisting 1st (III) oxidation step followed by (II) +...
Biocompatible chemistry enables abiotic reactions to be interfaced with metabolic pathways in living microorganisms. This includes both native and de novo biosynthetic processes access feedstocks, intermediates products vivo. Herein we report a biocompatible Lossen rearrangement that is catalysed by phosphate the bacterium Escherichia coli for chemical transformation of activated acyl hydroxamates primary amines cells. Using para-carboxylated substrate, reaction can used generate metabolite...