Abstract Aim To examine the difference in LV reverse remodeling parameters elderly patients (65 years and more) who underwent transcatheter aortic valve replacement (TAVR) minimally invasive cardiac surgery (MICS AVR). Methods results This study analyzed data for a consecutive series of TAVR (n=109) AVR MICS (n=50) due to severe or critical AS at our Cenetr between January 2018 August 2023. We also included from follow-ups: 30 day, 60 day 1 year after replacement. Five deaths (4.0%) occurred...

Kawasaki disease (KD) is a mucocutaneous lymphonodular syndrome, vasculitis of unknown etiology that mainly affects children under the age 5 years. Today, KD most common cause acquired heart in developed countries. Given absence pathognomonic diagnosis disease, based solely on identification clinical signs and exclusion other clinically similar diseases. Timely therapy with intravenous immunoglobulin has significantly reduced incidence complications, such as coronary artery aneurysms, from...

The rapid growth of cardiovascular morbidity and high mortality rates patients with congenital heart disease requiring surgery have led to the search for new modern approaches treatment these groups patients. main trends today include use cardiaс implants synthetic biological origin. Of particular interest are scaffolds based on decellularized extracellular matrix, which in its functional structural characteristics is close native pericardium. In contrast analogues, such grafts can fully...

Aim. Determination of the most effective protocol for decellularization bovine pericardium.Methods.Bovine pericardium was decellularized following five protocols: group 1 -Ammonium Hydroxide + Triton X-100, 2 -1 % SDS Ammonium -Triton 3 SDS, 4 -Trypsin enzyme 5 -0,1 respectively.Histological, biomechanical properties and detection nucleic acids concentration in samples were studied.Results.The time groups is much longer than described previous scientific publication.Also, lower control...

Shortness of breath during physical exertion is a non-specific symptom that can hide such potentially dangerous diseases as structural or functional bronchopulmonary, coronary heart disease, cardiac but the frequent cause left ventricle diastolic dysfunction due to its significant hypertrophy. Pathogenetic mechanisms leading this require detailed study for possibility comprehensive approach in treatment patients with aim maximally improving their prognosis and quality life. Objective —...

The aim. To examine the significance of microribonucleic acids (miRNAs) and oxidative stress markers in predicting onset atherosclerosis connection between levels miRNAs individuals with coronary heart disease.
 Materials methods. Initially, 40 patients were divided as follows: 10 subjects without any lesions arteries (group 0), 4 non-stenotic 1), 26 significant multivessel atherosclerotic 2). Various biochemical parameters analyzed, including miRNA expression common markers.
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Background. The article deals with the actual problem of pediatric neurology, cardiology, and cardiac surgery, in particular, peculiarities neurodevelopment children congenital heart defects (CHD). purpose is to conduct a study stages stato-motor development (SMD) patients cyanotic after surgical treatment determine influence pathogenic factors on neurodevelopmental delay. Materials methods. Thirty-five CHD underwent examination at Center for Pediatric Cardiology Cardiac Surgery Ministry...

The article is devoted to the actual problem of children’s neurology, cardiology and cardiac surgery - namely, features neuropsychological development (NPD) in children with congenital heart defects (CHD). Purpose review modern research on diagnosis NPD CHD, which a necessary condition for optimizing patient care developing rehabilitation plan. topicality topic due lack early violation this category children. Consider damage brain defects. relationship between action various epigenetic...

Purpose: To evaluate the prognostic value of left ventricular global index and myocardial contraction fraction based on 2D echocardiography results in patients with coronary artery disease. Materials methods: Patients disease, confirmed by angiography ventriculography, were included prospective clinical study. 30 without disease a control group, 35 had monovascular lesions or non-stenosing atherosclerosis, 66 multivessel Left calculated using technique. Results: The groups comparable age,...

Kawasaki disease (KD) is a vasculitis of unknown origin, accompanied by fever and mucocutaneous syndrome, predominantly found in infants. KD the most common cause acquired heart children developed countries, which complicated occurrence coronary artery aneurysms 25% untreated patients due to vasculitis. The aim analyze guidelines American Heart Association, Single Hub Access Point for Paediatric Rheumatology Europe (SHARE), as well Japanese instructions on modern approaches diagnosis...

Deaths of children during physical education classes occur every year not only in Ukraine but also around the world, and these are always events that receive wide publicity. According to Centers for Disease Control Prevention (CDC), United States, about 2,000 young, apparently healthy people under age 25 die from sudden cardiac arrest. Aim - analyze causes arrest (SCA) adolescents activities identify main ways prevention SCA, providing family physicians with practical relevant information on...

Middle aortic syndrome (MAS) is a segmental narrowing of the abdominal or distal descending thoracic aorta that produced by congenital number acquired etiologies. MAS may be caused Takayasu’s temporal arteritis (giant cell arteritides), neurofibromatosis, fibromuscular dysplasia, retroperitoneal fibrosis, mucopolysaccharidosis, and Williams syndrome, congenital, ascribed to developmental anomaly in fusion maturation paired embryonic dorsal aortas.
 Aim this article present clinical case...

The aim: To investigate the effectiveness of using low concentrations sodium dodecyl sulfate (SDS) and cross-linking with EDC/NHS in decellularization process to create a potential bioimplant for cardiac surgery. Materials methods: Pericardial sacs were derived from 12-18 months bulls. Tissue was performed by 0.1% SDS following cross-linking. experiment included standard histological, microscopic, molecular genetic biomechanical methods. Scaffold tested vitro cytotoxicity biocompatibility....

Vascular ring (VR) is hard to diagnose prenatally and requires knowledge of anatomy the large vessels, anatomical variants VR special echocardiographic views. In this study we aimed find parameters which may predict diagnosis VR. From 2011 2017 isolated was established confirmed by computer tomography after birth in 39 cases (the main group). A control group comprised 47 fetuses with normal heart anatomy. The sizes all structures both groups were evaluated according normograms corresponding...

At the present time, left main (LM) stenting is an alternative to coronary artery bypass grafting in patients with disease (CAD) and haemodynamically significant LM lesion. Despite of long history interventions, long-term results are still poorly understood. Presented data conflicting need further affirmation.
 Aim. To investigate outcomes percutaneous intervention (PCI) lesions.
 Materials methods. The study included 27 CAD lesion who underwent PCI. risk was calculated using...

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The aim of the\* study was to estimate the properties scaffold obtained by decellularization bovine pericardium with a 0.1% solution sodium dodecyl sulfate. experiment included standard histological, microscopic, molecular genetic, and biomechanical methods. Scaffold tested in vitro for cytotoxicity vivo biocompatibility. A high degree removal cells their components from pericardium-derived matrix shown. Biomechanical characteristics artificial were same as those native pericardium. With...

Background. According to statistics, about 26 million people worldwide suffer from heart failure (HF). Currently, sodium-glucose cotransporter 2 inhibitors are widely prescribed for treatment of HF with reduced left ventricular ejec-tion fraction (LVEF) throughout the world. Therefore, prescribing drugs that have anti-hypoglycemic effect in patients without diabetes mellitus still raises some concerns, considering possible risk developing hypoglycemia.
 The aim. To assess dapagliflozin...

The aim. To analyze the structure of ischemic heart disease and prevalence myocardial ischemia with no ob-structive coronary arteries among patients who underwent elective angiography.
 Materials methods. We examined 1,200 a clinical diagnosis disease. After coro-nary angiography all non-stenotic hyperventilation challenge test to ex-clude vasospastic angina echocardiographic study intravenous administration dipyridamole assess index reserve longitudinal strain.
 Results. mean age...