A5100649245- Kruppel-like factors research
- Cancer-related gene regulation
- FOXO transcription factor regulation
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Renal and related cancers
- Urological Disorders and Treatments
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Chronic Myeloid Leukemia Treatments
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Metabolism and Genetic Disorders
- RNA Interference and Gene Delivery
- Orthopedic Surgery and Rehabilitation
- Diabetic Foot Ulcer Assessment and Management
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- Click Chemistry and Applications
- Signaling Pathways in Disease
- Cancer Mechanisms and Therapy
Xi'an Honghui Hospital
2010-2023
Xi'an Jiaotong University
2015-2023
Central South University
2023
Xiangya Hospital Central South University
2023
Zunyi Medical University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2021
Creative Commons
2020
Weatherford College
2020
Linyi People's Hospital
2020
Mayo Clinic
2016
Abstract Existing antiangiogenic approaches to treat metastatic hepatocellular carcinoma (HCC) are weakly effectual, prompting further study of tumor angiogenesis in this disease setting. Here, we report a novel role for sulfatase 2 (SULF2) driving HCC angiogenesis. Sulf2-deficient mice (Sulf2 KO) exhibited resistance diethylnitrosamine-induced and did not develop metastases like wild-type WT). The smaller less numerous tumors formed Sulf2 KO markedly lower microvascular density. In human...
// Xin Zheng 1, * , Tao Song Changwei Dou 1 Yuli Jia Qingguang Liu Department of Hepatobiliary Surgery, the First Affiliated Hospital Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China These authors have contributed equally to this work Correspondence to: Liu, e-mail: raymondzhengxin@foxmail.com Keywords: C-terminal binding protein 2, GLI family zinc finger Snail Family Zinc Finger epithelialmesenchymal transition, Hepatocellular carcinoma Received: November 12, 2014 Accepted: December...
Elevated expression of survivin is observed in a number cancer types, including human osteosarcoma. Few studies have demonstrated that levels can be considered an independent predictor survival for osteosarcoma patients. However, the underlying molecular mechanisms process carcinogenesis remain unclear. In current study, we evaluated biological effects knockdown on cell proliferation, colony formation rate, and sensitivity to chemotherapeutic agent cisplatin. We found two different lines,...
has been observed to act as a tumor suppressor through the targeting of different proteins in variety tumors.Our previous study indicated that miR-370 was able target forkhead box protein M1 (FOXM1) inhibit cell growth and metastasis human osteosarcoma cells.In this study, we reported FOXM1 interacted with β-catenin vitro vivo.Similar FOXM1, critical components Wnt signaling pathway, including β-catenin, c-Myc, Cyclin D1, were also highly expressed cells lines.Pharmacological inhibition or...
Sulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters binding sites for various signaling molecules. Here, we elucidated role of SULF2 in differentiation hepatic stellate cells (HSCs) into carcinoma-associated fibroblasts (CAFs) hepatocellular carcinoma (HCC) microenvironment mechanism underlying CAF-mediated HCC growth.The clinical relevance CAFs was examined using silico immunohistochemical (IHC) analyses. Functional studies...
Atrophic nonunion, a complicated failure of fracture healing, is still obscure regarding its molecular pathological mechanisms. Carboxyl-terminal binding proteins (CtBPs), an NADH-sensitive transcriptional corepressor family, are involved in many diseases, such as cancer and inflammation. Here, we found that CtBP2, but not CtBP1, was significantly overexpressed atrophic nonunion tissues compared to healthy controls. Using mass spectrometry assay, CtBP2 can form complex with histone...
Chemoresistance is a major barrier for the chemotherapy of osteosarcoma.The induction multidrug resistance protein 1 (MDR1), an ATP-dependent transporter, can efflux anti-cancer drugs, thereby decreasing chemosensitivity.However, actual involvement MDR1 in chemoresistance osteosarcoma cells has not been established.We obtained two cisplatin (CDDP)-resistant cancer stem cell (CSC) lines using sphere formation medium supplemented with CDDP.These CDDP-resistant CSC showed substantial...
The expression, function, and mechanism of FLOT1 (flotillin-1) remains unknown in gliomas. Here, the expression clinical value gliomas was bioinformatically experimentally analyzed via online omics data local tissues. Moreover, effects depletion on cell proliferation invasion were also detected. Besides, underlying roles N6-methyladenosine modification (m6A) upregulation further explored. results demonstrated that significantly upregulated positively correlated with advanced progression poor...
Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated overexpression of
Abstract Myocardial ischemia is a common reason that causes human death globally. Long noncoding RNA taurine upregulated 1 (TUG1) serves as an oncogene in variety of cancers. In this article, we aimed to investigate the role TUG1 and its underlying signal pathway hypoxia-induced myocardial cell injury. Cell viability, apoptosis, lactate dehydrogenase (LDH) release were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry, western blot assay, LDH...
Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of repair genes are still being investigated. In this study, we reveal that C-terminal binding protein (CtBP) interacting (CtIP) couples with three transcriptional regulators, CtBP1/2 heterodimer, histone deacetylase 1 (HDAC1), and two subunits activating (AP1) transcription factor to assemble a complex. This complex specifically controls expression four...
Decreased expression of proapoptotic genes can lead to the chemoresistenance in cancer therapy.Carboxyl-terminal binding protein 1 (CtBP1), a transcriptional corepressor with multiple oncogenic effects, has been previously identified suppress two [BAX (BCL2 associated X) and BIM (Bcl-2 interacting mediator cell death)] by assembling complex Forkhead box O3 (FOXO3a) transcription factor p300 histone acetyltransferase.However, upstream regulatory signaling CtBP1-p300-FOXO3a is obscure, effects...