A5101634684- Electromagnetic Simulation and Numerical Methods
- Electromagnetic Scattering and Analysis
- Superconducting and THz Device Technology
- Electromagnetic Compatibility and Noise Suppression
- Matrix Theory and Algorithms
- Microwave Engineering and Waveguides
- Physics of Superconductivity and Magnetism
- Cancer-related Molecular Pathways
- Low-power high-performance VLSI design
- Ubiquitin and proteasome pathways
- Numerical methods for differential equations
- Radio Frequency Integrated Circuit Design
- Advancements in Semiconductor Devices and Circuit Design
- Composite Material Mechanics
- Model Reduction and Neural Networks
- Power Systems and Technologies
- Numerical methods in engineering
- Quantum and electron transport phenomena
- Lattice Boltzmann Simulation Studies
- Quantum optics and atomic interactions
- Gyrotron and Vacuum Electronics Research
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
- Differential Equations and Numerical Methods
- RNA modifications and cancer
Southwest Jiaotong University
2015-2025
Tongji University
2018-2024
Van Andel Institute
2022-2024
Chengdu Third People's Hospital
2023
Weill Cornell Medical College in Qatar
2022
Laboratoire Modélisation et Simulation Multi-Echelle
2017-2021
Université Gustave Eiffel
2021
Weatherford College
2020
Xi'an Jiaotong University
2018-2019
Centre National de la Recherche Scientifique
2015-2017
The DNA sliding clamp PCNA is a multipurpose platform for polymerases and many other proteins involved in metabolism. topologically closed ring needs to be cracked open loaded onto by loader, e.g., the well-studied pentameric ATPase complex RFC (RFC1-5). CTF18-RFC an alternative loader found recently bind leading strand polymerase ε load DNA, but its structure loading mechanism have been unknown. By cryo-EM analysis of vitro assembled human CTF18-RFC–DNA–PCNA complex, we captured seven...
The root cause of the instability is quantitatively identified for explicit time-domain finite-element method that employs a time step beyond allowed by stability criterion. With identification cause, an unconditionally stable successfully created, which and accurate solely determined accuracy regardless how large is. proposed retains strength in avoiding solving matrix equation while eliminating its shortcoming step. Numerical experiments have demonstrated superior performance computational...
We study the multi-photon energy resolution and demonstrate photon counting up to about 30 photons at near-infrared wavelengths in a kinetic inductance detector made from aluminum (Al) film. The has lumped-element design comprising large interdigitated capacitor parallel with narrow inductive strip. A fiber-coupled lens is used focus light onto absorber minimize scattering. Detectors different designs film thicknesses are studied. From histogram of optimally filtered response pulse height,...
The Jamin effect, as a resistance arising from the morphological changes of droplets during two-phases flow in capillary tube, plays crucial role enhancing oil recovery efficiency (EOR) petroleum engineering. In present study, we investigate critical parameters effect sloped tube laden with water and sodium dodecyl sulfate (SDS) solutions, including velocity pressure difference. pinning behavior droplet is observed waterflood lower velocity, while depinning rupturing occur at higher...
Abstract UBR5 is a HECT domain E3 ubiquitin ligase that frequently amplified in breast, ovarian and prostate cancers. Heightened expression plays profound role tumor growth through immune‐dependent mechanisms; however, its mode of action driving metastasis has not been definitively delineated. Herein, we used tetracycline (Tet)‐inducible RNAi‐mediated silencing cell system to investigate how enables postsurgical mammary metastatic mouse lungs without the continuous influence primary lesion....
In this paper, guided by electromagnetics-based first principles, the authors develop a transient simulator that allows for simulation of an integrated circuit including both nonlinear devices and layout linear network in complexity. The proposed rigorously captures coupling between circuits network. addition, it bypasses step extraction, producing resistor-inductor-capacitor representation without any numerical computation. Moreover, permits almost embarrassingly parallel implementation on...
A fast electromagnetic simulator is developed to co-simulate the linear network and nonlinear circuits in an integrated circuit system. In this simulator, physical layout of a large-scale rigorously reduced single surface or few surfaces where are located. The reduction done analytically, and, hence, computational overhead minimal. system then split into so that both systems can be solved efficiently. equations rapidly by time-domain layered finite-element reduction-recovery method....
AbstractThe “optimal” speedup of an explicit and unconditionally stable time-domain method, without sacrificing accuracy, is the ratio time step required by accuracy to determined stability. In this work, significantly accelerating time-marching-based revealing modes for any given step, it demonstrated that feasible achieve a more than optimal speedup.Keywords: methodstime-domain methodsunconditionally methodsfinite-element methods
Abstract The coplanar waveguide (CPW) microwave resonators have been widely applied for solid-state quantum computation and single-photon detection. Based on the physical analysis high fidelity readouts of qubit(s), in this paper we design then fabricate accordingly desired aluminum (Al) film quarter-wavelength sapphire substrates. ultra-low temperature measurement results show that linearity internal quality factor under proper driving power is satisfied well qubit(s); phase- amplitude...
Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading complexes: RFC and CTF18-RFC load PCNA onto DNA, but ATAD5-RFC can only unload from DNA. The underlying structural basis of unloading is unknown. We show here that ATAD5 has two unique locking loops appear to tie the complex into a rigid structure, together with domain plugs DNA-binding chamber, prevent conformation changes required for DNA binding, likely explaining why exclusively unloader. These features...
Acute respiratory failure is a type of sepsis complicated by severe organ failure. We have developed new nomogram for predicting the 30-day risk death in patients through retrospective study.Data was collected and extracted from MIMICIV, with 768 eligible cases randomly assigned to primary cohort (540) validation (228). The final six factors were included Cox regression analysis create Nomogram, accuracy Nomogram assessed using C-index calibration curve, finally, clinical usefulness...
Accurate and efficient power grid analysis has become increasingly important in semiconductors chip design verification. It is one of the most computationally challenging tasks high performance processor analysis. Due to extremely large memory required store manipulate data, it no longer possible accommodate using or more serial processes on a single computer. The proposed method scale with sparse linear solver effectively distributes computing across multiple running different computers...
We originally develop a network analysis method to study the non-ideal superconducting resonator circuits. model device by 3-block serial network, consisting of input feedline, resonator-coupler and output feedline. show that resonance curve will be modified if non-negligible discontinuity (reflection) exists at or side resonator. The extracted parameters (such as coupling quality factor Q c ) from only fitting transmission deviate their true values defined in matched impedance conditions,...
The root cause of the instability is identified for explicit time-domain method that uses a time step beyond allowed by stability criterion. With identification cause, an unconditionally stable successfully developed in framework finite-element methods, and hence removing major computational bottleneck.
If the electromagnetic waves are scattered by periodic structure of media with different refractive indexes, a band gap in transmitted spectrum can be generated. This is photonic crystal whose usually uncontrollable as its parameters fixed after fabrication. Alternatively, based on quantum theory real space for single photons transporting along one-dimensional waveguide embed series two-level atoms, we propose here mechanical configuration to implement adjustable gap. It shown that if...
State-of-the-art electromagnetics-based circuit simulators perform simulation on the physical layout of an integrated circuit, size which can be large even for optimal-complexity simulator to analyze it efficiently. We find a frequency- and time-independent minimal-order model from DC high frequencies any prescribed accuracy based electromagnetics. The is only two RC circuits minimal such as tens RLC fullwave circuits, regardless original number input/output ports. Numerical experiments...
Abstract We present a new fitting method that can robustly and accurately fit the complex transmission curve of superconducting resonator in nonlinear regime. This takes into account varying internal current at different frequencies dependence inductance on <?CDATA $L = L_{0}(1+I^2/I_{*}^{2})$?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>L</mml:mi> <mml:mo>=</mml:mo> <mml:msub> <mml:mrow> <mml:mn>0</mml:mn> </mml:mrow> </mml:msub> <mml:mo...
An explicit and unconditionally stable time-domain finite-element method of linear complexity is developed for the simulation 3-D global interconnect network Numerical experiments have demonstrated that proposed outperforms both conditionally implicit in computational efficiency.
It has been nearly 110 years since the discovery of superconductors, and more than 30 high temperature superconductors (HTS). Great progress made in application superconducting electronics last two decades. HTS microwave devices have shown much higher perfomance traditional ones found their ways to industry applications mobile communication, radar, special communication applications. Owing ultrahigh sensitivity magnetic fields currents, quantum interference (SQUIDs) used as irresplacible...
The DC mode is a fundamental that comprises the solution of Maxwell's equations in physical problem. We present rigorous divide-and-conquer algorithm to extract efficiently from an arbitrary 3-D problem where both dielectrics and conductors can be arbitrarily shaped, inhomogeneous, lossy, dispersive. Numerical experiments have demonstrated validity proposed algorithm.