A5056354735- Pharmacogenetics and Drug Metabolism
- Biochemical and Molecular Research
- Steroid Chemistry and Biochemistry
- Analytical Chemistry and Chromatography
- Chemical Reactions and Isotopes
- Pharmaceutical Economics and Policy
- Plant and fungal interactions
- Microbial Natural Products and Biosynthesis
- Click Chemistry and Applications
- Metabolomics and Mass Spectrometry Studies
- Molecular spectroscopy and chirality
- Cancer Research and Treatments
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Trypanosoma species research and implications
- Microbial Metabolic Engineering and Bioproduction
Hypha Discovery (United Kingdom)
2018-2024
Biotransformation has a huge impact on the efficacy and safety of drugs. Ultimately effects metabolism can be lynchpin in discovery development cycle new drug. This article discusses application biotransformation drugs by mammalian systems, microorganisms, recombinant enzymes, covering active reactive metabolites, gut microbiome metabolism, how insights gained from studies influence drug design combined perspectives CRO specializing range techniques pharma scientists. We include commentary...
The drug discovery and development process encompasses the interrogation of metabolites arising from biotransformation drugs. Here we look at why, when how small-molecule drugs are synthesised perspective a specialist contract research organisation, with particular attention paid to projects for which regulatory oversight is relevant during this journey. To illustrate important aspects, recent case studies, trends learnings our experience making identifying over past ten years, along...
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing world, yet private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array diarylimidazoles was screened against ESKAPE pathogens, and results were made publicly available through Open Source Antibiotics (OSA) consortium (https://github.com/opensourceantibiotics). Of 18 compounds tested (at 32 μg/mL), 15 showed >90% growth...
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing world, yet private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array diarylimidazoles was screened against ESKAPE pathogens (https://en.wikipedia.org/wiki/ESKAPE) and results made publicly available through Open Source Antibiotics (OSA) consortium (https://github.com/opensourceantibiotics). Of 18 compounds tested (at 32...