A5062592597- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Diet, Metabolism, and Disease
- Genetics and Neurodevelopmental Disorders
- Health Literacy and Information Accessibility
- Electron Spin Resonance Studies
- Ginkgo biloba and Cashew Applications
- Ion Channels and Receptors
- Mobile Health and mHealth Applications
- Advanced NMR Techniques and Applications
- Telemedicine and Telehealth Implementation
- Diversity and Career in Medicine
- Lanthanide and Transition Metal Complexes
- Facial Nerve Paralysis Treatment and Research
- Lysosomal Storage Disorders Research
- Advanced Glycation End Products research
- Health and Medical Research Impacts
- Ear Surgery and Otitis Media
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Health and Disease Prevention
UNSW Sydney
2011-2024
St George Hospital
2024
Sutherland Hospital
2024
The University of Sydney
2007-2019
Schizophrenia Research Institute
2009-2018
Neuroscience Research Australia
2009-2018
Garvan Institute of Medical Research
2009
Pharmaceutical Biotechnology (Czechia)
2005-2006
Monash University
2004-2005
The schizophrenia brain is differentiated from the normal by subtle changes, with significant overlap in measures between and disease states. For past 25 years, has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to consider how pathological changes identified adult tissue can be accounted for aberrant developmental processes occurring during fetal, childhood or adolescent periods. To place neuropathology context requires...
Cannabis contains over 70 unique compounds and its abuse is linked to an increased risk of developing schizophrenia. The behavioural profiles the psychotropic cannabis constituent Δ9-tetrahydrocannabinol (Δ9-THC) non-psychotomimetic cannabidiol (CBD) were investigated with a battery tests relevant anxiety positive, negative cognitive symptoms Male adult C57BL/6JArc mice given 21 daily intraperitoneal injections vehicle, Δ9-THC (0.3, 1, 3 or 10 mg/kg) CBD (1, 5, 50 mg/kg). produced classic...
Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in endocannabinoid system across human postnatal life and determined whether they correspond to development markers for inhibitory interneurons, which shape development. used microarray with qPCR validation situ hybridisation quantify mRNA central receptor CB(1)R, synthetic enzymes (DAGLα 2-arachidonylglycerol [2-AG] NAPE-PLD anandamide), inactivating (MGL ABHD6 2-AG...
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive of cannabis, Δ9-tetrahydrocannabinol. Here we investigated whether Nrg1 HET respond differently CBD reverses schizophrenia-related phenotypes expressed by these mice. Adult male wild type-like littermates (WT) received vehicle or (1, 50 100...
Abstract Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to development psychosis-like symptoms after use. To test whether schizophrenia candidate gene neuregulin 1 (NRG1) modulates effects cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response repeated Δ9-tetrahydrocannabinol (THC, 10 mg/kg...
Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, accumulates in adipose tissue where it is stored for long periods time. Here we investigated whether conditions that promote lipolysis can liberate THC from adipocytes to yield increased blood levels THC.In vitro studies involved freshly isolated rat were incubated with before exposure lipolytic agent adrenocorticotrophic hormone (ACTH). A complementary vivo approach examined effects both food deprivation and...
Neuregulin 1 (NRG1) is linked to an increased risk of developing schizophrenia and cannabis dependence. Mice that are hypomorphic for Nrg1 (Nrg1 HET mice) display schizophrenia-relevant behavioural phenotypes aberrant expression serotonin glutamate receptors. mice also idiosyncratic responses the main psychoactive constituent cannabis, Δ9-tetrahydrocannabinol (THC). To gain traction on molecular pathways disrupted by hypomorphism Nrg1-cannabinoid interactions we conducted a proteomic study....
The effects of Δ9-tetrahydrocannabinol (Δ9-THC; 0.3, 1, 3 and 10 mg/kg), the fatty acid amide hydrolysis inhibitor URB-597 (0.1 0.3 on auditory olfactory go/no-go discrimination tasks were examined in rats. aims to assess (i) whether simple are sensitive cannabinoid interference (ii) manipulation endogenous levels with might have adverse perceptual cognitive functions. Thirsty rats trained nose poke at a ‘sniff port’, where odours briefly presented. After one odour (S+, lemon), licks made an...
Advanced glycation endproducts (AGE) have been implicated in the pathogenesis of diabetic complications, including cardiovascular dysfunctions. 3-benzyloxycarbonylmethyl-4-methyl-thiazol-3-ium bromide (C36), a novel AGE breaker, was investigated for its beneficial effects on system rats.The vitro breaking abilities C36 cross-links formed and vivo were assessed. After 4 weeks' treatment with C36, left ventricular functions (streptozotocin-induced) rats evaluated by haemodynamic studies....
Background The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, molecular alterations expression that underpin observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA transcripts throughout development HET mouse. In addition, regulation high-frequency (gamma) electrophysiological oscillations this associate...
Surgeons use the Internet and social media to provide health information, promote their clinical practice, network with clinicians researchers, engage journal clubs online campaigns. While surgical patients are increasingly Internet-literate, prevalence purpose of searching for information vary among patient populations. We aimed characterise colorectal surgeon (CRS) seek information.Members Colorectal Society Australia New Zealand under care CRS at Royal Prince Alfred Hospital, Sydney, were...
Background: The Sydney Facial Nerve Service is a multidisciplinary team that provides management of patients with facial nerve disorders, historically as an in-person format. coronavirus disease 2019 (COVID-19) pandemic resulted in shift to virtual format due infection control precautions. This study aims evaluate the acceptability telehealth for and clinicians care palsy. Methods: questionnaires were distributed either on email or mail out. Follow up telephone calls made non-responders....
The major psychoactive constituent of the Cannabis sativa plant, Δ 9 -tetrahydrocannabinol (THC), has been extensively investigated for its therapeutic and toxicological effects. Cannabidiol, another abundant but nonpsychotropic recently attracted renewed interest as a molecule. Preliminary reports antipsychotic, antihyperalgesic, anticonvulsant, neuroprotective antiemetic properties, ability to counteract certain effects traditional cannabinoid receptor ligands, have augmented by discovery...
Cannabis use is a well-established component risk factor for schizophrenia, particularly in adolescent individuals with genetic predisposition the disorder. Alterations to endocannabinoid system have been found prefrontal cortex of patients schizophrenia. Thus, we assessed whether molecular alterations exist signalling pathway during brain development mouse model schizophrenia gene neuregulin 1 (Nrg1). We analysed transcripts encoding key molecules heterozygous transmembrane domain Nrg1...
The aim of this report is to describe the management an iatrogenic diaphragmatic eventration following surgery relieve neurogenic symptoms thoracic outlet syndrome in a patient with prior history sleeve gastrectomy. We discuss case 46-year-old woman 6-month gastro-oesophageal reflux and dyspnoea. Imaging demonstrated left hemidiaphragm hiatus hernia. underwent laparoscopic plication hemidiaphragm, repair hernia, omega loop gastric bypass, satisfactory resolution her symptoms. This...
Karl, Tim; Long, Leonora; Boucher, Aurelie; McGregor, Iain; Huang, Xu-Feng; Arnold, Jonathon Author Information