A5024715654- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Bioinformatics
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Dementia and Cognitive Impairment Research
Gladstone Institutes
2020-2024
University of California, San Francisco
2020-2022
The University of Texas Medical Branch at Galveston
2019
Genetic mutations underlying familial Alzheimer's disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression mutated transgenes have yielded key insights mechanisms disease, those are subject to artifacts, including random genetic integration transgene, ectopic expression and non-physiological protein levels. The engineering novel using knock-in approaches addresses some limitations. With...
Abstract Altered expression of GABA receptors (GABA A Rs) has been implicated in neurological and psychiatric disorders, but limited information about region-specific R subunit healthy human brains, heteromeric assembly major isoforms, their collective organization across individuals, are roadblocks to understanding role non-physiological states. Here, by using microarray RNA-Seq datasets—from single cell nuclei global brain expression—from the Allen Institute, we find that transcriptional...
Abstract Theoretical and experimental work has demonstrated that excitatory (E) inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron network levels, fundamental role in proper brain function its impairment been linked numerous disorders. Over recent years, large amount of microarray RNA-Sequencing datasets have collected, however few studies made use these resources for exploring the balance global gene expression...