A5071974997- Pasture and Agricultural Systems
- Agriculture Sustainability and Environmental Impact
- Ruminant Nutrition and Digestive Physiology
- Botanical Research and Applications
- Phytochemical compounds biological activities
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Climate Change Policy and Economics
- Animal testing and alternatives
- Cancer Cells and Metastasis
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Soil Carbon and Nitrogen Dynamics
- Forest Management and Policy
- Amyotrophic Lateral Sclerosis Research
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Phytochemicals and Antioxidant Activities
Cardiff University
2018-2025
Bangor University
2021-2024
Hernia Center
1993
Bacterial cancer therapy (BCT) is emerging as an important option for treatment of solid tumours, with promising outcomes in preclinical trials. Further progress hampered by incomplete understanding how oncotropic bacteria, such attenuated strains Salmonella enterica serovar Typhimurium, colonise tumours and the responses both bacteria tumour cells to this colonisation. To model this, we have developed organoids that are permissive bacterial colonisation, replacing conventional commercially...
Bacterial cancer therapy (BCT) is emerging as an important option for the treatment of solid tumours, with promising outcomes in preclinical trials. Further progress hampered by incomplete understanding how oncotropic bacteria, such attenuated strains Salmonella enterica serovar Typhimurium, colonise tumours and responses both bacteria tumour cells to this colonisation. To model this, we developed organoids that are permissive bacterial colonisation, replacing conventional commercially...
The UK Climate Change Committee has recommended a 64% reduction in greenhouse gas emissions from the agriculture and land-use sector to meet 2050 Net Zero target UK. However, it is unclear how this can be achieved at farm level. Using detailed real data novel modelling approaches, we investigated management interventions afforestation that would required deliver within boundary. Baseline carbon footprints were calculated for twenty Welsh beef sheep farms using Agrecalc calculator, whilst...
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Male Wistar rats aged 6-26 months were obtained from the colony of The Gerontology Research Center National Institute on Aging, and pathological profiles assessed. One hundred animals sacrificed at 6, 12, 18, 21, 24, 26 used for cross-sectional determinations; also, 150 followed longitudinally when clinical signs moribundity appeared. Renal disease contributed most common pathology observed in both studies (found over 70% examined), with neoplasms a secondary problem (pituitary tumors by far...
Colorectal cancer (CRC) is the third most diagnosed worldwide and second highest cause of deaths (Sung et al., 2021). CRC prevention research crucial to reduce its impact on public health economy, as total cost in Europe amounts €12.2 billion annually (Hofmarcher 2020). Lifestyle diet play an important role numerous diseases including (Cena & Calder, 2020), with risk factors unhealthy diet, sedentary lifestyle, excess body weight (World Cancer Research Fund, 2018). It estimated that 54%...
CONTEXTThe UK Climate Change Committee has recommended a 64% reduction in greenhouse gas emissions from the agriculture and land-use sector to meet 2050 Net Zero target UK. However, it is unclear how this can be achieved at farm level.OBJECTIVEUsing real data novel modelling approaches, we investigated management interventions afforestation that would required deliver within boundary.METHODS Baseline carbon footprints were calculated for twenty Welsh beef sheep farms using Agrecalc...