A5020262303- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Contact Dermatitis and Allergies
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Consumer Attitudes and Food Labeling
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Skin Protection and Aging
- Regulation of Appetite and Obesity
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Pharmaceutical studies and practices
- Biochemical Analysis and Sensing Techniques
- Cervical and Thoracic Myelopathy
- Memory and Neural Mechanisms
- Pharmaceutical industry and healthcare
- Neuroendocrine regulation and behavior
- Pesticide Exposure and Toxicity
- Pluripotent Stem Cells Research
- Nicotinic Acetylcholine Receptors Study
Baylor College of Medicine
2020-2025
Neurological Research Institute
2022-2024
Texas Children's Hospital
2022-2024
Rice University
2019-2023
University of California, San Francisco
2022
The University of Texas Health Science Center at San Antonio
2020
Texas A&M University
2020
The University of Texas Health Science Center at Houston
2020
Abstract CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer’s disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP broadly expressed adult mouse brain, including within cortical and hippocampal neurons, where it detected at pre-synaptic terminals. Deletion of Cd2ap altered dendritic branching spine density, impaired ubiquitin-proteasome activity. Moreover, mice harboring either one or two copies germline null...
Co-transmission of multiple neurotransmitters from a single neuron increases the complexity signaling information within defined neuronal circuits. Superficial short-axon cells in olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet specific targets these their respective roles olfaction have remained unknown. Here, we implement intersectional genetics mice to selectively block GABA or superficial identify distinct cellular targets, impact on circuit function, behavioral...
Hospital length of stay (HLOS) after traumatic brain injury (TBI) is an important metric severity, resource utilization, and access to post-acute care services. Risk factors for protracted HLOS TBI require further characterization.
Sensory perception relies on the flexible detection and interpretation of stimuli across variable contexts, conditions, behavioral states. The basal forebrain is a hub for state regulation, supplying dense cholinergic GABAergic projections to various brain regions involved in sensory processing. Of neurons forebrain, parvalbumin (PV) somatostatin (SST) subtypes serve opposing roles towards regulating To elucidate role circuits sensory-guided behavior, we investigated signaling dynamics...
Obesity results from excessive caloric input associated with overeating and presents a major public health challenge. The hypothalamus has received significant attention for its role in governing feeding behavior body weight homeostasis. However, extrahypothalamic brain circuits also regulate appetite consumption by altering sensory perception, motivation, reward. We recently discovered population of basal forebrain cholinergic (BFc) neurons that suppression. Through viral tracing methods...
BACKGROUND Neurenteric cysts are rare congenital lesions from heterotopic endodermal tissue, often presenting with radiculopathy or myelopathy in young adults. Gross-total resection is curative; however, the surgical approach remains widely debated for cervicothoracic cases. While posterior common, anterior has had success The authors present first pediatric case of corpectomy gross-total a neurenteric cyst alongside an extensive literature review. OBSERVATIONS A 10-year-old male, who...
Neural circuit plasticity and sensory response dynamics depend on forming new synaptic connections. Despite recent advances toward understanding the consequences of plasticity, mechanisms driving are unknown. Adult-born neurons within olfactory bulb have proven to be a powerful model for studying providing broad accessible avenue into neuron development, migration, integration. We others shown that efficient adult-born integration hinges presynaptic activity in form diverse signaling...
Dietary supplements promoted for "skin, hair, and nail" health are becoming increasingly popular, although there is a lack of regulatory oversight. As no centralized database or repository these available, the aim this study was to provide an overview in sample retail stores, with focus on safety concerns.Dermatology were defined as those that featured words "skin", "hair", "nails", "beauty", "glow" product name tagline. Seven stores including drug, grocery, department, cosmetics surveyed...
Background and objective Dietary supplements advertised to “boost collagen” or for “skin, hair, nail” health are becoming increasingly popular, despite a lack of evidence support their use. These products not regulated by the United States (U.S.) Food Drug Administration (FDA), hence there is no centralized database listing current products. The goal this study was document examine labeling marketing methods these Methods Supplements including words “glow,” “beauty,” “skin,” “hair,” “nails”...
Structured Abstract AIM To estimate prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan. METHOD In this cross-sectional study, self-reported Sensory Processing Scale Inventory (SPS-I) was administered via REDCap between 2/1/22 and 8/15/22 to CP or their caregivers enrolled online MyCP Community Registry. We determined association SPS-I scores age (Pearson correlation) functional status as assessed using five validated classification systems for (ANOVA)....
The development of cell-type-specific gene therapy vectors for treating neurological diseases holds great promise, but has relied on animal models with limited translational utility. We have adapted an
Abstract It is becoming more broadly accepted that human-based models are needed to better understand the complexities of human nervous system and its diseases. The recently developed brain organotypic culture model one highly promising requires involvement neurosurgeons neurosurgical patients. Studies have investigated electrophysiological properties neurons in such ex vivo tissues, but maintenance other cell types within explanted remains largely unknown. Here, using single-nucleus RNA...
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Abstract To date, more than 100 clinical trials have used sequence-based therapies to address diseases of the pediatric central nervous system. The first targeted pathologies share common features: are severe; they due (mostly) single variants; variants well characterized within genome; and interventions technically feasible. Interventions range from intramuscular intravenous injection intrathecal intraparenchymal infusions. Whether therapeutic sequence consists RNA or DNA, whether is...
INTRODUCTION: Traumatic brain injury (TBI) presents a disproportionate biopsychosocial and economic burden on certain patient populations compared to others. Inpatient length of stay (LOS) emerges as proxy measure severity, resource utilization, access post-acute care. Identifying determinants prolonged LOS following TBI admission allows for the evaluation disparities in METHODS: The NTDB compiles trauma registry data across various U.S. centers. Our study’s inclusion criteria were adult...
Laparoscopic anterior lumbar interbody fusion (L-ALIF), which employs laparoscopic cameras to facilitate a less invasive approach, originally gained traction during the 1990s but has subsequently fallen out of favor. As envelope for endoscopic approaches continues be pushed, recurrence interest in and/or seems possible. Therefore, evaluating current evidence base regard this approach is much clinical relevance. To end, systematic literature search was performed according PRISMA (Preferred...
ABSTRACT Sensory perception relies on the flexible detection and interpretation of stimuli across variable contexts, conditions, behavioral states. The basal forebrain is a hub for state regulation, supplying dense cholinergic GABAergic projections to various brain regions involved in sensory processing. Of neurons forebrain, parvalbumin (PV) somatostatin (SST) subtypes serve opposing roles towards regulating To elucidate role circuits sensory-guided behavior, we investigated signaling...
Body weight homeostasis is regulated by balancing energy expenditure with caloric intake. Obesity, a major public health concern, often results via excess of unused associated overeating. The hypothalamus, which considered the master regulator homeostasis, has received significant attention for its role in governing feeding behavior and body homeostasis. However, extra-hypothalamic circuits throughout brain perceive, anticipate, adapt to food availability. We recently discovered population...