A5008564706- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- AI in cancer detection
- Mechanical Circulatory Support Devices
- Cancer and Skin Lesions
- Multiple Myeloma Research and Treatments
- Viral Infections and Immunology Research
- Artificial Intelligence in Healthcare
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Statistical Methods in Clinical Trials
- Synthesis and Biological Evaluation
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
University of California, San Francisco
2016-2025
UCSF Helen Diller Family Comprehensive Cancer Center
2021-2024
San Francisco VA Health Care System
2020-2023
San Francisco VA Medical Center
2020-2022
San Francisco General Hospital
2020
Ac, a long-lived α-emitter with half-life of 9.92 days, has garnered significant attention as therapeutic radionuclide when coupled monoclonal antibodies and other targeting vectors. Nevertheless, its clinical utility been hampered by potential off-target toxicity, lack optimized chelators for
The tumor uptake of large non-targeted nanocarriers primarily occurs through passive extravasation, known as the enhanced permeability and retention (EPR) effect. Prior studies demonstrated improved 4-arm 40 kDa star polyethylene glycol (StarPEG) polymers for cancer imaging by adding prostate-specific membrane antigen (PSMA) targeting small molecule ligands. To test PSMA-targeted delivery therapeutic efficacy, StarPEG nanodrugs with/without three copies PSMA-targeting ligands, ACUPA, are...
Abstract Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has limited treatment options and a poor prognosis. Recently, PSMA-targeted alpha particle therapy agents using Actinium-225 (225Ac) have shown promising results for treatment, but significant fraction of patients with advanced mCRPC demonstrate loss PSMA expression. We previously reported that PSMA-null PSMA-positive tumors can be detected treated effectively CD46-targeted radiopharmaceuticals. This study evaluates...
422 Background: Current clinical management and classification of prostate cancer is dependent upon specimen morphology assessment. Limited studies have focused on identifying mapping transcriptomic signatures within morphological variants. Additionally, the impact distance-relationship between benign tumor glands has yet to be identified. In this analysis, we profiled derived signature gene sets for variants assessed spatial distance from adjacent areas surrounding tissues. Methods: Four...
412 Background: Nguyen et al recently proposed an outcome-based radical prostatectomy (RP) histologic classifier (PMID 38828674, “Canary histology risk group”), combining all high-risk carcinoma patterns into “unfavorable histology,” versus absence as “favorable histology.” We examine whether this classifier, with additional stratification of favorable, is applicable to prostate biopsies for stratification. Methods: Archival databases one single institution were searched patients long term...
// Cristina L. Abrahams 1 , Xiaofan Li Millicent Embry Abigail Yu Stellanie Krimm Sarah Krueger 2 Nancy Y. Greenland 3 Kwun Wah Wen Chris Jones Venita DeAlmeida Willy A. Solis Shannon Matheny Toni Kline Alice Yam Ryan Stafford Arun P. Wiita Trevor Hallam Mark Lupher and Arturo Molina Sutro Biopharma, Inc., South San Francisco, California, USA MI Bioresearch, Ann Arbor, MI, Department of Pathology Laboratory Medicine, University CA, Correspondence to: Molina, email: amolina@sutrobio.com...
Chronic lung allograft dysfunction (CLAD) is the major barrier to long-term survival following transplantation, and new mechanistic biomarkers are needed. Lymphocytic bronchitis (LB) precedes CLAD has a defined molecular signature. We hypothesized that this LB signature would be associated with in small airway brushings independent of infection. quantified RNA expression from transbronchial biopsies, using RNAseq digital counting, respectively, for 22 cases 27 matched controls. metagene...
No AccessJournal of UrologyAdult Urology1 Jul 2019Correlation a Commercial Genomic Risk Classifier with Histological Patterns in Prostate CancerThis article is commented on by the following:Editorial Comment Nancy Y. Greenland, Li Zhang, Janet E. Cowan, Peter R. Carroll, Bradley A. Stohr, and Jeffry P. Simko GreenlandNancy Greenland Department Anatomic Pathology, University California-San Francisco, San California , ZhangLi Zhang Medicine, Epidemiology Biostatistics, CowanJanet Cowan...
Abstract Background Molecular testing of prostate cancer biopsies with Gleason pattern 4 suggests the expansile cribriform is more aggressive than glomerulation pattern. These two extreme patterns have not been compared at prostatectomy. We hypothesized that prostatectomy would be associated histopathologic and molecular features aggressiveness greater risk biochemical recurrence (BCR) Methods In a retrospective cohort study, radical reports or were analyzed for percentage total 4,...
Lymphocytic bronchitis (LB) precedes chronic lung allograft dysfunction. The relationships of LB (classified here as Endobronchial or E-grade rejection) to small airway (A- and B-grade) pathologies are unclear. We hypothesized that gene signatures common rejection would be present in LB. studied two partially overlapping transplant recipient cohorts: Cohort 1 included large brushes (6 cases 18 post-transplant referents). Differential expression using DESeq2 was used for pathway analysis...
Aims A recent outcome‐based, radical prostatectomy study defined > 0.25 mm diameter to distinguish large versus small cribriform glands, with associated worse recurrence‐free survival. This evaluates whether identification of glands in Grade Group 2 patients at biopsy is adverse pathology prostatectomy. Methods and results Tumours containing slides for 133 prostate cancer subsequent were re‐reviewed (diameter mm). The primary outcome was (Grade Groups 3–5; stage pT3a or greater, pN1)....
Among Gleason pattern 4 types, cribriform is associated with the worst outcomes. We hypothesized that larger patterns would be increased Decipher scores and higher biochemical recurrence (BCR) risk in 3+4=7 prostatectomy patients.The slide from patients who underwent January 2016 to March 2020 on which was performed re-reviewed for score patterns, large defined as acini greater than 12 lumens simple or fewer lumens. Differences were analyzed a generalized linear model controlling pathology...
Abstract Background The use of cell block (CB) preparation is underused in urine cytology (UC) and varies among hospitals. In addition to confirming a diagnosis, CBs can be useful cases metastatic disease, diagnoses requiring immunohistochemical (IHC) staining, for ancillary studies. role this study examine the performance UC at three affiliated teaching Materials Methods A retrospective review with CB was conducted county hospital, Veterans Affairs tertiary university‐based hospital. For...
Gastric-type endocervical adenocarcinoma (GAS) is an uncommon type of that not associated with human papillomavirus infection. This diagnosis relatively rare and may portend a worse prognosis than usual-type adenocarcinoma. Subtle morphological features make it under-recognised diagnostic challenge. Study the cytological individual cases valuable in order to increase awareness this entity.The pathology database our institution was searched for GAS all surgical specimens each patient were...