A5100385095- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Gaze Tracking and Assistive Technology
- Virus-based gene therapy research
- Environmental Toxicology and Ecotoxicology
- Immunotherapy and Immune Responses
- Innovation and Knowledge Management
- Risk and Safety Analysis
- Brain Tumor Detection and Classification
- Monoclonal and Polyclonal Antibodies Research
- Social Robot Interaction and HRI
- interferon and immune responses
- Autonomous Vehicle Technology and Safety
- Nicotinic Acetylcholine Receptors Study
- Human-Automation Interaction and Safety
- Urban Stormwater Management Solutions
- Chemical Synthesis and Analysis
- Sustainable Supply Chain Management
- Business Process Modeling and Analysis
- Surface Roughness and Optical Measurements
- Innovation and Socioeconomic Development
- Cholinesterase and Neurodegenerative Diseases
- Reliability and Maintenance Optimization
- Traffic control and management
- Underground infrastructure and sustainability
Shanghai Electric (China)
2025
Tsinghua University
2018-2024
Shenyang Agricultural University
2024
China Agricultural University
2019-2024
Jiangsu University of Science and Technology
2024
Beijing University of Posts and Telecommunications
2021
University of Wrocław
2019
University of Basel
2019
Emory University
2019
University of North Carolina at Chapel Hill
2019
The activation of multiple Pattern Recognition Receptors (PRRs) has been demonstrated to trigger inflammatory responses and coordinate the host's adaptive immunity during pathogen infections. use PRR agonists as vaccine adjuvants reported synergistically induce specific humoral cellular immune responses. However, incorporating increases complexity design manufacturing. In this study, we discovered a polymer that can activate both Toll-like receptor (TLR) pathway cyclic GMP-AMP synthase...
Currently, the clinical application of protein/peptide therapeutics is mainly limited to modulation diseases in extracellular spaces. Intracellular targets are hardly accessed, owing largely endosomal entrapment internalized proteins/peptides. Here, we report a strategy design and construct peptides that enable endosome-to-cytosol delivery based on an extension "histidine switch" principle. By substituting Arg/Lys residues cationic cell-penetrating (CPPs) with histidine, obtained...
Guiding robots, in the form of canes or cars, have recently been explored to assist blind and low vision (BLV) people. Such robots can provide full partial autonomy when guiding. However, pros cons different forms for guiding remain unknown. We sought fill this gap. designed autonomy-switchable robotic cane car. conducted a controlled lab-study (N=12) field study (N=9) on BLV. Results showed that received better walking performance subjective ratings study, whereas participants used more...
Abstract Materials‐based antigen delivery systems can augment the immune response by improving uptake in antigen‐presenting cells, targeting lymph nodes, prolonging exposure, enhancing cross‐presentation, etc. Recent research revealed that some carriers activate innate pathways without additional adjuvant. Here, a vaccine platform (antigen nanocapsules) constructed one‐step situ polymerization is reported, weaving biodegradable polymer network around surface. This simple technology allowed...
Herein, we genetically encode an esterified glutamic acid analogue (BnE) into proteins, and demonstrate that BnE can be applied in different types of site-specific protein modifications.
Quadruped robots have the potential to guide blind and low vision (BLV) people due their highly flexible locomotion emotional value provided by bionic forms. However, development of quadruped rarely involves BLV users' participatory designs evaluations. In this paper, we conducted two empirical experiments both in indoor controlled outdoor field scenarios, exploring benefits drawbacks robots. The results show that nowadays commercial exposed significant disadvantages usability trust compared...
ABSTRACT Increasingly frequent urban floods strain the traditional grey infrastructure, overwhelming capacity of drainage networks and causing challenges in managing stormwater. The heavy precipitation leads to flooding damage systems. Consequently, efficient mitigation strategies for have been researched deeply. Green infrastructure (GI) has proved be effective responding increasing risk flood alleviate pressure on However, as primary stormwater management, there is still a lack attention...
Crucial for cell activities, ion channels are key drug discovery targets. Although small-molecule and peptide modulators dominate channel discovery, antibodies emerging as an alternative modality. However, challenges persist in generating potent antibodies, especially with limited extracellular epitopes. We herein present a bi-epitopic crosslinking strategy to overcome these challenges, focusing on Na
Purpose The purpose of this study is to conceptualize the paradigm meaningful innovation (MI) by exploring theoretical basis, identifying its core concepts and key processes, supporting it with evidence from leading world-class enterprises. Design/methodology/approach Based on a systemic literature review evolution paradigms, builds conceptual framework explicate process MI. Moreover, horizontal embedded case GREE electric appliances conducted further enrich, refine support proposed...
Brain tumors are usually diagnosed manually by the doctors from Magnetic Resonance Images, which decreases efficiency of diagnosis process. Facing situation that brain Images needs effective methods to increase speed and enhance accuracy, we proposed algorithms using Convolutional Neural Network, MobileNet, AlexNet models help classify tumor while also developed an interface system connect algorithm directly hospital system. We utilized grouped dataset whether there is occurred in images....
Abstract Currently, the clinical application of protein/peptide therapeutics is mainly limited to modulation diseases in extracellular spaces. Intracellular targets are hardly accessed, owing largely endosomal entrapment internalized proteins/peptides. Here, we report a strategy design and construct peptides that enable endosome‐to‐cytosol delivery based on an extension “histidine switch” principle. By substituting Arg/Lys residues cationic cell‐penetrating (CPPs) with histidine, obtained...
A histidine-rich endosomal escape peptide, as described by Juanjuan Du et al. in their Research Article (e202304692), is capable of mediating efficient endosome-to-cytosol transport peptide/protein cargo, depicted the cover picture butterflies escaping from bubbles trapping them. Once combined with antibody-mediated endocytosis, this strategy enables cell-specific cytosolic delivery functional proteins.
Real engineering systems, such as autonomous vehicles (AVs), contain sophisticated architecture and equip some critical components with sensors to monitor their condition. Since not all of the are monitored, these systems termed partially monitored systems. Traditional reliability evaluation approaches based on system models may fail for due a lack clear knowledge about internal structure. Previous research conditional monitoring signals has yielded achievements in individual component well...
MeSO 2 Ar catalyst, light C(sp 3 )-H alkylation proton/redox
Drawing on a knowledge-based view (KBV), this study investigates the ontology of concept business model (BM) and builds an integrated framework in which to explore its architecture dynamics. In framework, BM can be viewed as structured knowledge cluster contains both explicit implicit parts. The consists three levels: components, sub- themes overall BM. Based this, design imitation BMs is conceptualized dynamic process (implicit explicit) creation cross-boundary diffusion. proposed could...