A5061003549- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- Insect-Plant Interactions and Control
- Trypanosoma species research and implications
Harvard University
2021-2023
Abstract Wolbachia , a maternally inherited intracellular bacterial species, can manipulate host insect reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality crosses between infected males and uninfected females. CI is encoded two prophage genes, cifA cifB . coupled with the sterile technique, has been used field trials to control populations of dengue vector Aedes albopictus but CI-inducing strains are not known infect malaria Anopheles gambiae Here we show...
Insecticide resistance is under strong selective pressure in Anopheles mosquitoes due to widespread usage of insecticides vector control strategies. Resistance mechanisms likely cause changes that profoundly affect mosquito physiology, yet it remains poorly understood how pressures imposed by may alter the ability host and transmit a Plasmodium infection. From pyrethroid-resistant field-derived gambiae s.l. mosquitoes, we established resistant (RES) susceptible (SUS) colonies either...
Artemisinin (ART) combination therapies have been critical in reducing malaria morbidity and mortality, but these important drugs are threatened by growing resistance associated with mutations
Abstract Wolbachia infections are a fascinating example of reproductive parasitism with strong potential to combat vector-borne diseases, due their combined ability spread in insect populations and block pathogen replication. Though the factors mediating notable manipulation cytoplasmic incompatibility (CI) have now been identified as prophage WO genes cifA cifB , relative role these is still intensely debated, different models claiming that CI requires either both or alone. Here we...
Abstract Insecticide resistance is under strong selective pressure in Anopheles mosquitoes due to widespread usage of insecticides vector control strategies. Resistance mechanisms likely cause changes that profoundly affect mosquito physiology, yet it remains poorly understood how pressures imposed by may alter the ability host and transmit a Plasmodium infection. From pyrethroid-resistant field-derived gambiae s . l mosquitoes, we performed selection experiments establish resistant (RES)...