Prospective study.To compare the efficacy of 24-hour and 72-hour antibiotic prophylaxis in preventing surgical site infections (SSIs).Antimicrobial practice has become a universally accepted protocol for minimizing postoperative complications related to infections. Although is an practice, debate exists with regard type its administration duration various procedures.Our institute tertiary care hospital more than 100 spinal surgeries per year spine disorders department orthopedics. We...

Malaria is one of the most important parasitic diseases in world. It remains a major public health problem Africa and responsible for annual death over million children below age five years. The Plasmodium falciparum widespread etiological agent human malaria has become increasingly resistant to standard antimalarial drugs. Therefore, this necessitates continuous effort search new drugs, particularly with novel modes action. medicinal plants have invariably been rich source drugs some use...

Objective: To study the adverse events following immunization (AEFI) with Covishield, a coronavirus disease– 2019 (COVID-19) vaccine. Materials and Methods: A prospective observational was conducted among 422 Covishield vaccinees based on inclusion exclusion criteria after institutional ethics committee approval. They were followed up at end of 1 2 weeks first dose vaccine, details collected. AEFIs classified using system organ classification, World Health Organization-Uppsala Monitoring...

Inadequate knowledge and underreporting of medical device-associated adverse events (MDAEs) were observed among health-care professionals (HCPs) in studies carried out other countries. In India, HCP's knowledge, attitude, practice (KAP) regarding materiovigilance have not been explored extensively. Hence, the present study was to assess KAP nurses working a tertiary care teaching hospital South India.This is descriptive, cross-sectional conducted nurses. A self-administered, validated...

Introduction: The novel Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), has been considered a major life-threatening danger to the human population worldwide. traditional Indian medicines also play an important role as possible therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. Among Siddha medicines, Kabasura kudineer is formulation composed of 15 ingredients used against fever respiratory infections. Aim:...

The Indo-Swiss symposium on pharmacogenomic strategies for the implementation of personalized medicine was conducted as part Jawaharlal Institute Postgraduate Medical Education and Research Integrated Pharmacogenomics Program in Puducherry, India, 19 November 2022. hybrid mode. theme impact pharmacogenomics achievement medicine/precision clinical setting. sought to promote interaction among participants initiate future collaborative research projects. also served a platform young researchers...

Background: Topical antifungals especially azole group of drugs are effective agents in the treatment dermatophytoses producing 100% clinical and mycological cure. Each them vary having specific characteristics to tackle several challenges like high relapse rate, recurrences quality life. Aims Objectives: To compare efficacy safety Eberconazole Sertaconazole tinea infection. Materials Methods: This was a randomized, observer-blinded, parallel-group study conducted at dermatology out-patient...

Background Adverse drug reactions (ADRs) to tuberculosis (TB) drugs are a significant concern for medical professionals and health authorities. events due drug-resistant TB (DRTB) treatment among the most important reasons interruption. Methods This study was an observational conducted patients diagnosed with (pulmonary/extrapulmonary) receiving antitubercular therapy (ATT) (first line/second-line drugs) irrespective of their age gender. The who consented participate, registered under...

Abstract A fistula between the colon and seminal vesicles following low anterior resection is an uncommon post-operative complication. This report details case of a 68-year-old patient diagnosed with locally advanced mid-low rectal cancer (T3N2M0). He underwent short-course radiotherapy consolidation chemotherapy (RAPIDO), followed by laparoscopic resection. With background diabetes BMI 36, being registered blind, it was decided not to give him defunctioning stoma. The immediate post-op...

Abstract: Tuberculosis is a chronic infective respiratory disease that has been known to mankind for centuries and still responsible higher rates of morbidity mortality globally. Repurposing drugs as host-directed therapies an add-on drug tuberculosis promising scope study it may have significant impact in reducing the treatment duration complications tuberculosis. Host-directed therapy strategy target host its immune mediators pro anti-inflammatory pathways, thus modifying them with achieve...

Abstract Background We present a case of 39 year old female patient, with BMI 37.5 and background hypertension scheduled for bariatric gastric sleeve surgery. During the surgery, incidentally, left paraduodenal hernia was identified. The incidence is 0.03% all hernias, which makes it rare to present. Method contents reduced. defect visualised repaired. Haemostasis achieved. Results postoperative period uneventful. patient followed up regularly in clinic no further complaints. Conclusion In...

Aim and Objectives: This study evaluated the acute repeated dose toxicity effects of Clevira Syrup Polyherbal formulation (CSPHF), which was prepared from ten different herbs, well known widely used in traditional medicine for management viral infections other inflammatory disease conditions. Individually these herbs (Carica papaya, Melia azedarach, Andrographis paniculata, Vetiveria zizanioides, Trichosanthes dioica, Cyperus rotundus, Zingiber officinale, Piper nigrum, Mollugo Cerviana...

Toxic epidermal necrolysis (TEN) is a rare life-threatening drug-induced mucocutaneous skin disease with mortality rate of approximately 30%. Nimesulide preferential cyclo-oxygenase (COX-2) inhibitor which frequently used for its antipyretic, anti-inflammatory and analgesic activity. Here, we report case nimesulide induced toxic in 57 years old male patient. This patient was admitted the hospital symptoms sloughing fluid filled blisters all over body following counter intake fever. The drug...