A5006594253- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Psoriasis: Treatment and Pathogenesis
- Heart Rate Variability and Autonomic Control
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Sexual function and dysfunction studies
- Epilepsy research and treatment
- Acute Lymphoblastic Leukemia research
- Ophthalmology and Eye Disorders
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Genetics and Neurodevelopmental Disorders
- Cardiac Health and Mental Health
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Cholinesterase and Neurodegenerative Diseases
- Immunodeficiency and Autoimmune Disorders
- Neurotransmitter Receptor Influence on Behavior
- Vitamin D Research Studies
- Cancer-related cognitive impairment studies
Institute of Molecular and Translational Medicine
2024-2025
Jawaharlal Institute of Post Graduate Medical Education and Research
2016-2025
University Hospital Olomouc
2024-2025
Palacký University Olomouc
2024-2025
Optimisation Thérapeutique en Neuropsychopharmacologie
2023
Université Paris Cité
2018-2023
Inserm
2023
Délégation Paris 5
2018
Sorbonne Université
2018
Sorbonne Paris Cité
2018
Abstract Background Polymorphisms in thiopurine methyltransferase (TPMT) are a predominant cause of azathiopurine-induced leukopenia the Western countries. The exact role these polymorphisms Indian population with dermatological disorders is uncertain. Methods We included consecutive patients on Azathioprine who were initiated for from south India. Three TPMT (c.238 G > C, c.460 A, and c.719A G) assessed. A comparison proportion adverse events to azathioprine, especially...
Autophagy activation contributes to chemotherapy resistance in several cancers, including ovarian cancer. Hydroxychloroquine (HCQ) is an autophagy inhibitor inhibiting the fusion of autophagosome with lysosome and has been repurposed as anti-cancer agent. In this randomized phase II study, we used HCQ combination standard platinum sensitive relapsed cancer (PSROC) patients. Patients were a 1:1 ratio receive (carboplatin paclitaxel/gemcitabine) or without HCQ. Those received additional 200mg...
Introduction: Autophagy plays a role in chemotherapy resistance by facilitating cell survival under stress conditions many malignancies, including ovarian cancers. The use of ascitic fluid to study autophagy biomarkers is an emerging approach, with potential advantages over tissue-based studies cancer research. This aimed standardize reproducible laboratory methods for detecting and quantifying the patients. Methods: Ascitic samples were analyzed using three techniques 30 patients: (1)...
To determine the adverse drug reaction (ADR) profile of risperidone and their association with dopamine (DRD2 - 141 C Ins/Del/rs1799732) serotonin receptor (5HTR2C -759 C>T/rs3813929) gene polymorphisms in patients schizophrenia.The study was conducted among 289 who were diagnosed schizophrenia on treatment (4-8 mg/day)-based therapy for a minimum 4 weeks. Genotyping carried by real-time quantitative polymerase chain reaction. All observed occurrences ADRs during study. Changes prolactin...
Background: The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens disease call faster alternatives. Material & methods: In search predictive biomarkers response, blood methylomes 28 patients were analyzed before 4 weeks into risperidone therapy. Results: Several CpGs exhibiting response-specific temporal dynamics identified in otherwise temporally stable noticeable global response-related...
Abstract Treatment response to antipsychotic drugs is variable and conflicting results have been obtained while studying the influence of DRD 2 HTR genetic variants on drug efficacy. To explore further, present study aimed assess ‐141 C Ins/Del, Taq1A 2A ‐1438 G/A, 102T/C 2C ‐759 C/T polymorphisms in risperidone patients with schizophrenia. The was conducted among n = 320 South Indian schizophrenia who received treatment (4–8 mg per day) for a minimum four weeks. Genotyping done by real‐time...
Plasticity of neural synapses is known to be involved in the complications bipolar disorder (BD) patients. Matrix metalloproteinases (MMPs) play a role synaptic plasticity and memory. Even though elevated MMP-9 levels are reported neuropsychiatric disorders, there limited data about gene polymorphism BD. The objectives study was investigate genotype frequency allele genetic variant (rs 17576) BD its association with disease severity.Eighty cases 80 controls were recruited study. genotyping...
Heart rate variability (HRV) is an important marker of cardiac autonomic modulation. Metabolic syndrome (MetS) can alter modulation, raising the risk cardiovascular disease (CVD). Poincaré plot analysis (PPA) a robust scatter plot-based depiction HRV and carries similar information to traditional measures. However, no prior studies have examined relationship between PPA measures among different levels MetS. We evaluated association Poincare heart indices adults with MetS.We measured...
The Indo-Swiss symposium on pharmacogenomic strategies for the implementation of personalized medicine was conducted as part Jawaharlal Institute Postgraduate Medical Education and Research Integrated Pharmacogenomics Program in Puducherry, India, 19 November 2022. hybrid mode. theme impact pharmacogenomics achievement medicine/precision clinical setting. sought to promote interaction among participants initiate future collaborative research projects. also served a platform young researchers...
Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic (pre-MetS) possesses two MetS components but does not meet the diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status pre-MetS subjects. In this study, we sought examine functions determine which component more responsible for impaired functions. A total 182...
To study the ocular biometric parameters in PACD patients and to compare them with normal control subjects. identify role of genetic polymorphisms PCMTD1 COL11A1 genes our population pathogenesis. This cross-sectional comparative included age-matched Patients who underwent prior laser iridotomy or intraocular surgery those using miotics were excluded from study. The comprehensive ophthalmological evaluation slit lamp biomicroscopy, applanation tonometry, gonioscopy, optic disc evaluation....
Abstract Genetic variations in the receptor, metabolizing enzymes and transporters may explain a part of variation anti-emetic response to ondansetron among cancer patients. This study assesses role ABCB1 genetic polymorphisms efficacy ondansetron-based medication for cisplatin-based chemotherapy South Indian The frequencies common (rs1045642; C > T , rs1128503; rs2032582; G / A ) were studied 234 patients receiving chemotherapy. Comparison nausea vomiting with respect number episodes...
Introduction: Interleukin-10 (IL-10) is a major anti-inflammatory cytokine, which plays an important role in regulating inflammatory responses of the immune system. Changes IL-10 level and its function can cause imbalance response, be associated with various disease conditions. Aim: To study influence vitamin D status gene promoter polymorphism (rs1800871) on circulating cytokine levels apparently healthy South Indian population. Materials Methods: A cross-sectional was conducted at...