During the last few decades, group B Streptococcus (GBS) has emerged as an important pathogen. The major reservoirs for GBS are vagina and peri-anal regions/rectum, colonization of these regions is a risk factor subsequent infection in pregnant women newborns.A prospective study was performed to determine prevalence rectum antibiotic susceptibility pattern isolates. We also aimed identify factors associated with colonization. vaginal rectal swabs were inoculated Todd-Hewitt broth later...

Autophagy activation contributes to chemotherapy resistance in several cancers, including ovarian cancer. Hydroxychloroquine (HCQ) is an autophagy inhibitor inhibiting the fusion of autophagosome with lysosome and has been repurposed as anti-cancer agent. In this randomized phase II study, we used HCQ combination standard platinum sensitive relapsed cancer (PSROC) patients. Patients were a 1:1 ratio receive (carboplatin paclitaxel/gemcitabine) or without HCQ. Those received additional 200mg...

Introduction: Autophagy plays a role in chemotherapy resistance by facilitating cell survival under stress conditions many malignancies, including ovarian cancers. The use of ascitic fluid to study autophagy biomarkers is an emerging approach, with potential advantages over tissue-based studies cancer research. This aimed standardize reproducible laboratory methods for detecting and quantifying the patients. Methods: Ascitic samples were analyzed using three techniques 30 patients: (1)...

The study aims, in infertile men, (i) to assess oxidative stress parameters semen plasma and (ii) the effect of antioxidants those with abnormal parameters.This was an interventional study.Ninety men attending infertility clinic a tertiary center were enrolled study.The present conducted departments obstetrics gynecology biochemistry center. Ethical approval obtained from institute ethics subcommittee, between July 2014 2016. on two groups 45 normal group 1 2.Malondialdehyde (MDA) value...

Abstract Stress and depression have been reported in gestational diabetes mellitus (GDM). Though inflammation oxidative stress are associated with depression, there no reports of link cardiometabolic risks (CMR) to GDM. Normal pregnant women (control group, n = 164) GDM (study 176) at 36th week gestation were recruited for the study. Blood pressure (BP), body composition, heart rate variability (HRV), glycated hemoglobin (HbA1C), markers insulin resistance, stress, endothelial dysfunction,...

The factors associated with the outcome of trial labour after one previous Caesarean Section; a retrospective cohort study. A observational study was performed on all eligible consecutive singleton pregnancies planned for Section (TOLAC) over period 18 months to success rate vaginal birth (VBAC) and find out successful failed TOLAC. All data were entered in electronic format analysed detail. Of 1324 women studied, VBAC 65.3% incidence scar rupture 0.5%. composite adverse maternal (postpartum...

Vulvovaginal candidiasis (VVC) is caused by overgrowth of Candida species in the female lower genital tract and most commonly albicans. The production various virulence factors may attribute to their pathogenicity. Hence, this study was aimed determine spp. causing VVC.A total 51 were isolated prospectively from 50 patients among 211 clinically suspected cases VVC. haemolytic activity, biofilm production, proteinase phospholipase activity esterase detected standard methods. Statistical...

The covid-19 pandemic has impacted the management of non-covid-19 illnesses. Epithelial ovarian cancer (EOC) requires long-duration multidisciplinary treatment. Teleconsultation and shared care are suggested solutions to mitigate consequences pandemic. However, these may be challenging implement among patients who come from lower economic strata. We report disastrous impact on EOC by comparing were treated during with those in previous year. collected following data newly diagnosed EOC: time...

Objectives: To assess the plasma markers of endothelial dysfunction: VonWillebrand factor (vWF), Platelet derived microparticles (PMPs), and Endothelin-1 (ET-1) in various types hypertensive disorders pregnancy correlate with outcome.Methods: Plasma levels vWF, PMPs ET-1 were analyzed by ELISA kits gestational hypertension (GH), late onset preeclampsia (LOPE), early (EOPE), eclampsia (E) control pregnant women (CPW) during third trimester. The age at time delivery (GA) birthweight (BW) baby...

Wernicke’s encephalopathy (WE) is an uncommon neurological complication in pregnancies complicated with hyperemesis due to thiamine deficiency. In women hyperemesis, inadvertent glucose administration prior supplementation triggers the development of manifestations. Delay diagnosis can lead maternal morbidity, and one-third cases may persistence some deficit. With early recognition supplementation, complete recovery reported. We report a case WE complicating triplet pregnancy gravidarum,...

Background: Limited studies have been conducted to evaluate the utility of indices for prediction adverse neonatal outcomes in hypertensive disorders pregnancy (HDP).Method: A total 174 pregnant women with HDP (gestational hypertension, late onset preeclampsia, and early preeclampsia) 49 controls were sampled during third trimester. Preterm birth, low birth weight, fetal, infant mortality Apgar scores assessed.Results: Multivariate analysis confirmed systolic blood pressure (SBP), time...

Hypertensive Disorders of Pregnancy (HDP) are one the most widespread complications pregnancy that affects both mother and foetus. It has been observed in Preeclampsia, release soluble angiogenic factors from ischemic placenta into maternal plasma plays a crucial role pathogenesis.To assess Soluble Endoglin (sEng) Transforming Growth Factor (TGF-β1) levels various types HDP to correlate these markers with outcome.A total 128 pregnant women were recruited study was carried out for period...

Objectives: To find out the early neonatal outcome (morbidity and mortality) of babies born by caesarean section (CS) to compare outcomes between elective emergency CS. Methods: A longitudinal study was conducted in a tertiary care hospital. Maternal characteristics were noted. Results: total 750 neonates enrolled 37% Out children 55% male newborns 45% females. The NICU (neonatal intensive unit) admission requirement 24%, whereas 3.33% died within 7 days life. Neonatal morbidity higher CS,...

Background: Purpose of this study was to evaluate the efficacy and safety different routes administration misoprostol - 50µg oral, 25µg vaginal sublingual for induction labour in women with premature rupture membranes after 34 weeks gestation.Methods: Women admitted ward (PROM) gestation requiring were randomized into three groups. A total 246 participated assigned groups receive either oral (n=80) or misoprostol(n=83) (n=83). The doses repeated 4 hourly till active established up a maximum...

Background: Premature termination of pregnancy because unmanageable maternal complications in hypertensive disorders (HDP) results adverse neonatal outcome. Identification biochemical derangements associated with may help the better medical management mother resulting outcomes. Method: Healthy pregnant women (C); gestational hypertension (GH), and preeclampsia (late [LP] early [EP] onset) were studied. Maternal serum redox markers adipokines evaluated for their association complications....

BACKGROUND: The prevalence of iron-deficiency anemia in pregnant Indian women is reportedly quite high. Despite the sustained efforts current national control program and undisputed efficacy iron-folic acid supplementation (IFAS), onslaught has not been curtailed, probably as a result noncompliance to IFAS. objective this study was assess effect direct monitoring by family members, counseling health professionals, other variables on adherence IFAS Puducherry, India.MATERIALS AND METHODS: A...

We aimed to study the factors including model for end stage liver disease (MELD) score in predicting mortality women with pregnancy-specific diseases (P-sLD). A total of 154 clinical jaundice were studied which 138 diagnosed P-sLD. The most common P-sLD was HELLP syndrome (51.9%) followed by acute fatty pregnancy (AFLP) (17.5%). mean age 26.3 ± 4.7 years and gestational 35.1 4.2 weeks. maternal death rate 26.8% cause coagulopathy sepsis. MELD among non survivors 25.98 8.17 compared 17.29...