A5009182600- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Plant responses to elevated CO2
- Plant pathogens and resistance mechanisms
- Listeria monocytogenes in Food Safety
- Computational Drug Discovery Methods
- Microencapsulation and Drying Processes
- Venous Thromboembolism Diagnosis and Management
- Diabetic Foot Ulcer Assessment and Management
- Microbial Inactivation Methods
- Neurological disorders and treatments
- Mycotoxins in Agriculture and Food
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- GABA and Rice Research
- Neurological Disease Mechanisms and Treatments
- Nematode management and characterization studies
- Bioinformatics and Genomic Networks
- Diagnosis and Treatment of Venous Diseases
- Seed and Plant Biochemistry
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
Texas Tech University Health Sciences Center
2024-2025
Texas Tech University
2024-2025
University of Copenhagen
2025
University Medical Center of El Paso
2025
Universitat Autònoma de Barcelona
2018
Synapse dysfunction is an early event in Alzheimer's disease (AD) caused by various factors such as Amyloid beta, p-tau, inflammation, and aging. However, the exact molecular mechanism of synapse AD largely unknown. To understand this, we comprehensively analyzed synaptosome fraction postmortem brain samples from patients cognitively normal individuals. We conducted high-throughput transcriptomic analyses to identify changes microRNA (miRNA) mRNA levels synaptosomes extracted brains both...
ABSTRACT INTRODUCTION Alzheimer’s disease (AD) lacks a less invasive and early detectable biomarker. Here, we investigated the biomarker potential of miR-501-3p miR-502-3p using different AD sources. METHODS MiR-501-3p expressions were evaluated in CSF exosomes, serum familial sporadic fibroblasts B-lymphocytes by qRT-PCR analysis. Further, analyzed APP, Tau cells media exosomes. RESULTS significantly upregulated exosomes relative to controls. MiRNA levels high accordance with amyloid plaque...
MicroRNA-502-3p (MiR-502-3p), a synapse enriched miRNA is considerably implicated in Alzheimer's disease (AD). Our previous study found the high expression level of miR-502-3p AD synapses relative to controls. Further, was modulate GABAergic function via modulating GABA A receptor subunit α-1 (GABRA1) protein. The current attempted examine impact on other proteins, synaptic mitochondrial morphology and hippocampal neuron genes. Mouse neuronal (HT22) cells were transfected with overexpression...
Synapse dysfunction is the root cause of Alzheimer's disease (AD). Uninterrupted and regulated synapse action crucial to maintain healthy brain function. Our previous study discovered microRNA-502-3p (miR-502-3p), a synapse-specific miRNA, highly expressed at AD synapses. Further, in vitro studies unveiled biological relevance miR-502-3p modulating GABA receptor function, synaptic activity mitochondrial morphology. Current focuses investigate role vivo using stereotaxic injection...
Parkinson's disease (PD) is the second most common neurodegenerative condition after Alzheimer's. Abnormal accumulation of alpha-synuclein (α-syn) aggregates disrupts balance dopaminergic (DA-ergic) synapse components, interfering with dopamine transmission and leading to synaptic dysfunction neuronal loss in PD. However exact molecular mechanism underlying DA-ergic cell SNpc not known. MicroRNAs (miRNAs) are observed various compartments neural elements including bodies, nerve terminals,...
Abstract MiRNAs are currently being studied for their biomarker potential in many diseases, including Alzheimer’s disease (AD). Here, we explored the of miR-502-3p/miR-501-3p cerebrospinal fluid (CSF) exosomes accordance with amyloid plaques and neurofibrillary tangles (NFTs) severity AD brain. The expression were analyzed CSF isolated from unaffected controls (UC) samples. levels examined Aβ1–40, Aβ1–42, Tau, p-Tau neuropathology upregulated relative to UC exosomes. MiR-502-3p level was...
Abstract Background Alzheimer’s disease (AD) continues to be the leading cause of dementia. Few treatment options exist manage AD. It is essential diagnose AD early slow its progression; however, there are very limited diagnostic tools accurately MicroRNAs (MiRNAs) currently being studied for their biomarker potential in many diseases, including This study explores miR‐502‐3p and miR‐501‐3p cerebrospinal fluid (CSF) exosomes patients relationship severity amyloid plaques neurofibrillary...