Full term pregnancy early in life is the most effective natural protection against breast cancer women. Rats treated with chemical carcinogen are similarly protected by a previous from mammary carcinogenesis. Proliferation and differentiation of gland does not explain this phenomenon, as shown relative ineffectiveness perphenazine, potent mitogenic differentiating agent. Here, we show that short treatment nulliparous rats levels estradiol 17β progesterone has high efficacy protecting them...

Abstract The mortality and morbidity rates of pancreatic cancer are high because its extremely invasive metastatic nature. Its lack symptoms, late diagnosis chemo–resistance the ineffective treatment modalities warrant development new chemo–therapeutic agents for cancer. Agents from medicinal plants have demonstrated therapeutic benefits in various human cancers. Nimbolide, an active molecule isolated Azadirachta indica , has been reported to exhibit several properties. This study assessed...

Abstract Activation of the serine–threonine protein kinase AKT has emerged as a central feature epithelial–mesenchymal transition (EMT), which is initial step for metastasis in many cancer models, including colorectal cancer. The focus our study was to dissect role and its molecular regulation EMT HCT‐116 cells stably overexpressing (AKT/HCT‐116) showed significantly higher cell proliferation compared with vector‐transfected (pCMV/HCT‐116). Elevated expression important EMT‐related...

Pancreatic cancer is one of the most lethal cancers. Increasing incidence and mortality indicates that there still much lacking in detection management disease. This partly due to a lack specific symptoms during early stages Several growth factor receptors have been associated with pancreatic cancer. Here, we investigated if an RNA interference approach targeted IGF-IR could be effective efficient against metastasis. For that, evaluated effects IGF-1R inhibition using small interfering...

// Sushmita Bose Nandy 1 , Arunkumar Arumugam Ramadevi Subramani Diego Pedroza 2 Keziah Hernandez Edward Saltzstein 3 and Rajkumar Lakshmanaswamy 1,2 Center of Excellence in Cancer Research, Department Biomedical Sciences MSB1, El Paso, Texas, USA Graduate School Sciences, Sadie Annabelle Garbar Breast Care Center, Texas Tech University Health Paul L. Foster Medicine, Correspondence to: Lakshmanaswamy, email: Keywords : breast cancer, stem cells, miR-125a, LIFR, hippo signaling Received...

Growth hormone receptor (GHR) plays a vital role in breast cancer chemoresistance and metastasis but the mechanism is not fully understood. We determined if GHR could be potential therapeutic target for estrogen negative (ER-ve) cancer, which are highly chemoresistant metastatic. was stably knocked down ER-ve cells its effect on cell proliferation, metastatic behavior, chemosensitivity to docetaxel (DT) assessed. Microarray analysis performed identify downstream targets involved...

It is well established that pregnancy early in life reduces the risk of breast cancer women and this effect universal. This phenomenon parity protection against mammary also observed rodents. Earlier studies have demonstrated short-term administration estradiol (E) combination with progesterone mimics protective rats. In study, lowest effective E dosage for preventing was determined. Rats were injected N -methyl- -nitrosourea at 7 weeks age; 2 later, rats subjected to sustained treatment 20...

// Ramadevi Subramani 1 , Elizabeth Gonzalez 2 Sushmita Bose Nandy Arunkumar Arumugam Fernando Camacho Joshua Medel Damilola Alabi Rajkumar Lakshmanaswamy 1, Center of Emphasis in Cancer Research, Department Biomedical Sciences, Texas Tech University Health Sciences Center, Paul L. Foster School Medicine, El Paso, Texas-79905, USA Graduate Correspondence to: Lakshmanaswamy, email: rajkumar.lakshmanaswamy@ttuhsc.edu Keywords: pancreatic cancer, gedunin, metastasis, hedgehog/gli signaling,...

Plant-based medicines are useful in the treatment of cancer. Many breast cancer patients use complementary and alternative medicine parallel with conventional treatments. Neem is historically well known Asia Africa as a versatile medicinal plant wide spectrum biological activities. The experiments reported herein determined whether administration an ethanolic fraction leaf (EFNL) inhibits progression chemical carcinogen-induced mammary tumorigenesis rat models. Seven-week-old female Sprague...

Abstract Background Increased expression of the progesterone receptor membrane component 1 (PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a regulatory and potential therapeutic target, oncogenic PGRMC1 not studied. Methods The impact on cancer growth progression was studied following chemical inhibition alteration expression, evaluated by using online-based gene datasets human tissue. MTS, flow cytometry, qPCR, Western blotting, confocal microscopy...

Sex hormones play a critical role in sex differences and cardiovascular disease risk associated with metabolic syndrome (MS) inflammation. However, the associations of hormone ratios inflammatory markers are unclear according to age differences. We evaluated MS inflammation among males females.

Parkinson's disease (PD) is the second most common neurodegenerative condition after Alzheimer's. Abnormal accumulation of alpha-synuclein (α-syn) aggregates disrupts balance dopaminergic (DA-ergic) synapse components, interfering with dopamine transmission and leading to synaptic dysfunction neuronal loss in PD. However exact molecular mechanism underlying DA-ergic cell SNpc not known. MicroRNAs (miRNAs) are observed various compartments neural elements including bodies, nerve terminals,...

Abstract Introduction The experiments reported here address the question of whether a short-term hormone treatment can prevent mammary tumorigenesis in two different genetically engineered mouse models. Methods Two models, p53 -null epithelial transplant and c- neu mouse, were exposed to estrogen progesterone for 2 3 weeks, respectively, followed development tumors. Results In model, 2-week exposure during immediate post-pubertal stage (2 4 weeks after transplantation) decreased by 70 88%....

Obesity and diabetes are associated with increased breast cancer risk worse disease progression once is diagnosed; however, the exact etiology behind these observations remains to be fully elucidated. Due global obesity/diabetes pandemic, it imperative understand how diseases promote enhance other common cancers. In this study we demonstrate that hyperglycemia promotes by altering leptin/IGF1R AKT/mTOR signaling. To our knowledge, show for first time in epithelial cells, alone directly...

Hypoxanthine phosphoribosyl transferase 1 (HPRT1) is traditionally believed to be a housekeeping gene; however, recent reports suggest that it upregulated in several cancers and associated with clinical outcomes. HPRT1 located on chromosome X encodes the HPRT enzyme, which functions recycling nucleotides supply for DNA RNA synthesis actively dividing cells. Here, we used transcriptomic analyses interrogate its expression across all known cancer types elucidated role regulating gene breast...