A5019303855- Marine Invertebrate Physiology and Ecology
- Marine Ecology and Invasive Species
- Planarian Biology and Electrostimulation
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- interferon and immune responses
- Steroid Chemistry and Biochemistry
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Biochemical Acid Research Studies
- Systemic Lupus Erythematosus Research
- Microbial Metabolism and Applications
- Biochemical and Structural Characterization
- Immune Cell Function and Interaction
- Streptococcal Infections and Treatments
University of Oklahoma Health Sciences Center
2012-2022
Oklahoma Medical Research Foundation
2021-2022
University of Central Oklahoma
2012-2021
The cholesterol-dependent cytolysins (CDCs) are pore-forming toxins that have been exclusively associated with a wide variety of bacterial pathogens and opportunistic from the Firmicutes Actinobacteria, which exhibit Gram-positive type cell structure. We characterized first CDCs Gram-negative species, include Desulfobulbus propionicus species Widdel 1981 (DSM 2032) (desulfolysin [DLY]) Enterobacter lignolyticus (formerly cloacae) SCF1 (enterolysin [ELY]). DLY ELY primary structures show they...
Abstract Lipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization utilization cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue due to injury-induced activation pluripotent somatic cells called neoblasts. Here, we identify two intestine-enriched orthologs apolipoprotein b, apob-1 apob-2 , which mediate transport neutral stores from intestine target tissues including neoblasts,...
Abstract Lipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization utilization cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue due to injury-induced activation pluripotent somatic cells called neoblasts. Here, we identify two intestine-enriched orthologs apolipoprotein b, apob-1 apob-2, which mediate transport neutral stores from intestine target tissues including neoblasts,...
Dihydrodipicolinate synthase (DHDPS) catalyzes the formation of dihydrodipicolinate from pyruvate and L‐aspartate‐β‐semialdehyde (ASA). The enzyme first committed step for biosynthesis L‐lysine in bacteria plants. Escherichia coli is feedback inhibited by lysine, end‐product pathway. Although numerous x‐ray structures have been solved DHDPS a number organisms, few mechanistic kinetic studies done on enzyme. We undertaken study pH dependence parameters order to elucidate acid‐base chemical...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is about 10 times more common among women than men. This sex bias was previously attributed to hormones. However, while hormones are abnormal in both men and with SLE, the best evidence supports that hormone abnormalities caused by SLE. Studies of four-genotype mice a lupus-like illness suggest an effect X chromosome numbers. Our previous studies have shown 47XXY 47XXX enriched SLE such we calculate present at same rate as 46XX women. Up...