A5047906684- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Hemoglobinopathies and Related Disorders
- Retinal Development and Disorders
- Blood groups and transfusion
- Complement system in diseases
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Iron Metabolism and Disorders
- Developmental Biology and Gene Regulation
- Planarian Biology and Electrostimulation
- Immunotherapy and Immune Responses
- Gold and Silver Nanoparticles Synthesis and Applications
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Chronic Myeloid Leukemia Treatments
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Marine Ecology and Invasive Species
- Platelet Disorders and Treatments
- Biochemical and Structural Characterization
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Marine Invertebrate Physiology and Ecology
Oklahoma Medical Research Foundation
2021-2025
PAX Scientific (United States)
2020-2024
RELX Group (Netherlands)
2024
Queen Elizabeth Hospital
2011-2023
Osaka University
2023
Chabot College
2022
Southend University Hospital NHS Foundation Trust
2021
Dean McGee Eye Institute
2011-2019
University of Oklahoma Health Sciences Center
2005-2019
Ministry of Health
2019
Abstract To understand the mechanisms of cell fate determination in vertebrate retina, time course generation major types needs to be established. This will help define and interpret patterns gene expression, waves differentiation, timing extent competence, many other developmental processes involved acquisition. A thorough retinal “birthdating” study has not been performed for laboratory rat, even though it is species choice contemporary studies retina. We investigated spatial pattern...
The Drosophila wing is decorated with a regular array of distally pointing hairs. In the pupal wing, hairs are formed from micro-villus like prehairs that contain large bundles actin filaments. distal orientation reveals proximal-distal polarity within epithelium. We have used F-actin staining to examine early stages prehair development in both wild-type and mutant wings. found striking correlation between hair subcellular location for assembly prehair. all derived at vertex hexagonally...
Many neurodegenerative diseases are known to occur and progress because of oxidative stress, the presence reactive oxygen species (ROS) in excess cellular defensive capabilities. Age related macular degeneration (AMD), diabetic retinopathy (DR) inherited retinal share stress as a common node upstream blinding effects these diseases. Knockout Vldlr gene results mouse that develops intraretinal subretinal neovascular lesions within first month age is an excellent model for form AMD called...
Abstract Iptacopan (LNP023) is a novel, oral selective inhibitor of complement factor B under clinical development for paroxysmal nocturnal hemoglobinuria (PNH). In this ongoing open-label phase 2 study, PNH patients with active hemolysis were randomized to receive single-agent iptacopan twice daily at dose either 25 mg 4 weeks followed by 100 up years (cohort 1) or 50 200 2). At the time interim analysis, 13 enrolled, all 12 evaluable efficacy achieved primary endpoint reduction in serum...
ABSTRACT The tissue polarity genes in Drosophila are required to coordinate cell within the plane of epidermis. Evidence date suggests that these may encode components a novel signal transduction pathway. Three genes, frizzled (fz), dishevelled (dsh), and prickle (pk) share similar phenotype, suggesting they function together single process. dsh is also known as mediator wingless (wg) signaling variety developmental patterning processes fly. In this study, we make use fz transgene...
Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical scavenging activities. The ability of nanoceria to maintain cellular redox balance makes them ideal candidates for treatment retinal diseases whose development is tightly associated with oxidative damage. We have demonstrated that our stable water-dispersed delay photoreceptor cell degeneration in rodent models prevent pathological neovascularization vldlr mutant mice. objectives the current study were...
Venom has only been recently discovered to be a basal trait of the Anguimorpha lizards. Consequently, very little is known about timings toxin recruitment events, venom protein molecular evolution, or even relative physical diversifications system itself. A multidisciplinary approach was used examine evolution across full taxonomical range this ∼130 million-year-old clade. Analysis cDNA libraries revealed complex transcriptomes. Most notably, three new cardioactive peptide types were...
The origin and evolution of venom proteins in helodermatid lizards were investigated by multidisciplinary techniques. Our analyses elucidated novel toxin types resultant from three unique domain-expression processes: 1) first full-length sequences lethal isoforms (helofensins) revealed this type to be constructed an ancestral monodomain, monoproduct gene (beta-defensin) that underwent tandem domain duplications encode a tetradomain, with possible protein fold; 2) monodomain (encoding...
Extrinsic cues and intrinsic competence act in concert for cell fate determination the developing vertebrate retina. However, what controls how precise is control are largely unknown. We studied regulation of by examining order which individual retinal progenitor cells (RPCs) generate daughters. Experiments were performed Xenopus laevis, whose full complement formed 2 days. lineage-labeled RPCs at optic vesicle stage. Subsequently we administered a cycle marker, 5-bromodeoxyuridine (BrdU)...
Purpose Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in vitro. Previously, we demonstrated CeNPs had neuroprotective and anti-angiogenic properties rodent retinal degeneration neovascularization models. However, the cellular mechanisms duration of activity preventing photoreceptor cell loss still unknown. In this study, sought to answer these questions using P23H-1 rat, an autosomal...
ABSTRACT Extracellular vesicles (EVs) are secreted nanoparticles composed of a lipid bilayer that carry lipid, protein, and nucleic acid cargo between cells as mode intercellular communication. Although EVs can promote tissue repair in mammals, their roles animals with greater regenerative capacity not well understood. Planarian flatworms capable whole‐body regeneration due to pluripotent somatic stem called neoblasts proliferate response injury. Here, using transmission electron microscopy,...
Abstract Salt marshes are recognized as blue carbon ecosystems for their ability to rapidly sequester organic (OC) via sedimentation. For this reason, there is growing interest in managing these systems help mitigate climate change. However, order sediment accretion offset ongoing CO 2 emissions, matter undergoing burial must be derived from contemporary primary production. To investigate the provenance of OC sequestered by salt marshes, we analyzed concentration and isotope composition (δ...
Abstract Lipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization utilization cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue due to injury-induced activation pluripotent somatic cells called neoblasts. Here, we identify two intestine-enriched orthologs apolipoprotein b, apob-1 apob-2 , which mediate transport neutral stores from intestine target tissues including neoblasts,...
The mesencephalic and metencephalic region (MMR) of the vertebrate central nervous system develops in response to signals produced by isthmic organizer (IsO). We have previously reported that LIM homeobox transcription factor Lmx1b is expressed within chick IsO, where it sufficient maintain expression secreted wnt1. In this paper, we show zebrafish express two orthologs, lmx1b.1 lmx1b.2, rostral demonstrate these genes are necessary for key aspects MMR development. Simultaneous knockdown...
Background: Clinical significance of germinal center B-cell (GCB) and non-GCB sub-categorization, expression MYC, BCL2, BCL6, CD5 proteins Epstein Barr virus encoded RNA (EBER) positivity in diffuse large lymphoma (DLBCL) remain controversial. Could these biomarkers accurately identify high risk DLBCL patients? Are BCL2 BCL6 feasible as baseline testing to predict c-Myc, or gene rearrangements? Aims: To investigate prognostic values GCB/non-GCB Double Protein Expression Lymphoma (DPL),...
Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical scavenging activities.The ability of nanoceria to maintain cellular redox balance makes them ideal candidates for treatment retinal diseases whose development is tightly associated with oxidative damage.We have demonstrated that our stable water-dispersed delay photoreceptor cell degeneration in rodent models prevent pathological neovascularization vldlr mutant mice.The objectives the current study were...
To remain globally competitive, there is increasing pressure for universities to incorporate a greater use of technology and innovation into their curriculum. In response, many higher education institutions have adopted blended learning approach, which combines traditional face-to-face delivery with online teaching resources, deliver course content. This paper documents the implementation resources in first-year accounting unit, outlines subsequent changes monitors its impact on outcomes....