A5046726437- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Phytochemicals and Antioxidant Activities
- Prenatal Screening and Diagnostics
- Protein Hydrolysis and Bioactive Peptides
- Lipoproteins and Cardiovascular Health
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Eating Disorders and Behaviors
- Insect Utilization and Effects
- Bioactive Compounds in Plants
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Morinda citrifolia extract uses
- Blood donation and transfusion practices
- Silk-based biomaterials and applications
- Medical Research and Treatments
- Parvovirus B19 Infection Studies
- Phytochemistry and biological activity of medicinal plants
- Neonatal Health and Biochemistry
- Natural product bioactivities and synthesis
- Acute Kidney Injury Research
- Hibiscus Plant Research Studies
- Heavy Metals in Plants
- Genetic Associations and Epidemiology
Universiti Tunku Abdul Rahman
2016-2024
Chengdu University of Traditional Chinese Medicine
2021
Universiti Putra Malaysia
2011-2018
Universiti Teknologi MARA
2018
Sonication is recognized as a potential food processing method to improve the functional properties of fruit juice. This study evaluated effects different sonication durations (20, 40, and 60 min) thermal pasteurization on nutritional, antioxidant, microbial noni Fresh juice served control. The main organic acids detected were malic (57.54−89.31 mg/100 mL) ascorbic (17.15−31.55 acids. Compared with fresh sample, concentrations these compounds significantly improved (p < 0.05) in min...
The aim of this study was to examine the antioxidant capacity Trypsin‐hydrolyzed corn silk proteins, specifically radical scavenging, ferric reducing and anti‐lipid peroxidation activities, as well stability after heating simulated gastrointestinal digestion. Among 1–5‐h hydrolysates, 1‐h Trypsin hydrolysate (T1H) strongest. T1H exhibited stronger H 2 O [half maximal effective concentration (EC 50 ) = 156.44 µg/mL] superoxide 0.33 mg/mL) scavenging activities than glutathione, carnosine...
Fetal hemoglobin (HbF) is the predominant in red cells during fetal life. Just after birth, level of HbF decreases gradually to <1%, and replaced mainly by adult (HbA) (∼97%). However, higher levels could be associated with HbE/β-thalassemia, a complex thalassemia intermedia diverse clinical severity ranging from mild-to-severe anemia. This study investigates correlation laboratory data HbE/β-thalassemia individuals.
Summary Introduction Alpha thalassaemia is a highly prevalent disease globally and well‐known public health problem in Malaysia. The deletional forms of the mutation are most common found alpha thalassaemia. three this region include ‐‐ SEA deletion, ‐α 3.7 rightward 4.2 leftward deletions. prevalence rate triplication cases such as ααα anti3.7 anti4.2 not known Malaysia although it plays role exacerbating clinical phenotypes beta carriers. Recently, there have been more reported rare...
Summary Introduction: Dried blood spots (DBS) are currently the recommended sample collection method for newborn screening programmes in America. Early diagnosis of beta‐thalassaemia is essential as it provides an added advantage especially sickle cell disease. Beta‐thalassaemia frequency high many poor countries, and cost using commercial DNA extraction kits can be prohibitive. Our study assessed three methods that use minimal reagents materials to extract from DBS identification. Methods:...
The diverse clinical phenotype of hemoglobin E (HbE)/β-thalassemia has not only confounded clinicians in matters patient management but also led scientists to investigate the complex mechanisms involved maintaining delicate red cell environment where, even with apparent similarities α- and β-globin genotypes, tells a different story. BTB CNC homology 1 (BACH1) protein is known regulate gene transcriptions during terminal differentiation erythroid cells. With mutations HbE/β-thalassemia...
Hemoglobin (Hb) Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a non-deletional α-thalassemia variant found in Malaysia.An improvement the molecular techniques recent years has made identification of Hb much easier.For this study, total 26 intermedia and 10 trait blood samples were collected from patients.Common deletional genotypes determined using multiplex gap polymerase chain reaction (PCR) ARMS PCR techniques.Identification location on α-globin gene was carried out genomic sequencing...
The Filipino β°-deletion has been reported as a unique mutation in East Malaysia with severe phenotype due to the complete absence of β-globin chain synthesis. In this study, haplotype patterns gene cluster were used relate human genetic variation specific β-thalassaemia mutation.
Introduction: Dopamine receptor type 2 gene (DRD2 Taq1A, Taq1B and Taq1D) psychosocial factors such as eating behaviour physical activity engagement have been demonstrated by past studies, to impact obesity, eventually affect health status quality of life. However, personality traits were largely examined a direct or indirect risk factor for obesity with inconclusive results. Hence, this study investigates the predictive effect Five Factor on related (i.e., level motives activity, behaviour)...
Summary Introduction In Malaysia, β‐thalassaemia is a common inherited blood disorder in haemoglobin synthesis with carrier rate of 4.5%. Currently, PCR ‐incorporating techniques such as amplification refractory mutation system ( ARMS ) or reverse dot blot hybridization RDBH are used detection. allows single‐mutation identification using two reactions, one for wild type and another mutant alleles. requires probe immobilization optimization washing temperatures which time consuming. The aim...