A5051934351- Venomous Animal Envenomation and Studies
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Marine Invertebrate Physiology and Ecology
- Ion channel regulation and function
- Rabies epidemiology and control
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Intracranial Aneurysms: Treatment and Complications
- Alzheimer's disease research and treatments
- Insect and Pesticide Research
- Eicosanoids and Hypertension Pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Protein Kinase Regulation and GTPase Signaling
- Amphibian and Reptile Biology
- Healthcare and Venom Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Structural Characterization
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Moyamoya disease diagnosis and treatment
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Cerebrovascular and Carotid Artery Diseases
Monash University
2014-2023
Australian Regenerative Medicine Institute
2013-2022
The University of Queensland
2020-2021
Discovery Institute
2021
Baker Heart and Diabetes Institute
2016-2017
The University of Melbourne
2016
The Alfred Hospital
2016
Monash Medical Centre
2014
Pomona College
2007
Dietary intake of fruit and vegetables is associated with lower incidence hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated effect a high-fiber diet supplementation short-chain fatty acid acetate on gut microbiota prevention cardiovascular disease.Gut microbiome, cardiorenal structure/function, blood pressure were examined in sham mineralocorticoid excess-treated mice control diet, or supplementation. We also determined renal cardiac transcriptome treated...
Venom has only been recently discovered to be a basal trait of the Anguimorpha lizards. Consequently, very little is known about timings toxin recruitment events, venom protein molecular evolution, or even relative physical diversifications system itself. A multidisciplinary approach was used examine evolution across full taxonomical range this ∼130 million-year-old clade. Analysis cDNA libraries revealed complex transcriptomes. Most notably, three new cardioactive peptide types were...
Venom systems are key adaptations that have evolved throughout the tree of life and typically facilitate predation or defense. Despite venoms being model for studying a variety evolutionary physiological processes, many taxonomic groups remain understudied, including venomous mammals. Within order Eulipotyphla, multiple shrew species solenodons oral venom systems. morphological variation their delivery systems, it remains unclear whether represents ancestral state in this group is result...
Oxidative stress plays a central role in the pathogenesis of heart failure. We aimed to determine whether antioxidant N-acetylcysteine can attenuate cardiac fibrosis and remodeling mouse model Minipumps were implanted subcutaneously wild-type mice (n = 20) with cardiomyopathy secondary specific overexpression mammalian sterile 20-like kinase 1 (MST-1; n 18) administer (40 mg/kg per day) or saline for period 8 weeks. At end this period, function was assessed via echocardiography. Fibrosis,...
The binding of compounds to nicotinic acetylcholine receptors is great interest in biomedical research. However, progress this area hampered by the lack a high-throughput, cost-effective, and taxonomically flexible platform. Current methods are low-throughput, consume large quantities sample, or limited which targets can be tested. We describe novel assay utilizes label-free bio-layer interferometry technology, combination with adapted mimotope peptides, order measure ligand orthosteric site...
Background Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different the effects of by most other populations vipers. This study aimed investigate evidence in envenoming, response antivenom toxins responsible for myotoxicity. Methodology Findings Clinical features were assessed authenticated bite patients admitted a teaching hospital. Toxins isolated using high-performance liquid chromatography. In-vitro venom was...
The Papuan taipan (<i>Oxyuranus scutellatus canni</i>) is widely distributed throughout much of Papua New Guinea. Although neurotoxicity a major symptom envenomation, no neurotoxins have been isolated from this venom. Using series size exclusion chromatography steps, we report the isolation cannitoxin, presynaptic neurotoxin (44,848 Da) that represents approximately 16% whole toxin displayed high phospholipase A<sub>2</sub> (PLA<sub>2</sub>) activity (330 ± 5 μmol/min/mg) and caused...
This study investigated the in vitro toxic effects of Bitis arietans venom and ability antivenom produced by South African Institute Medical Research (SAIMR) to neutralize these effects. The (50 µg/mL) reduced nerve-mediated twitches chick biventer muscle 19% ± 2% initial magnitude (n = 4) within 2 h. inhibitory effect was significantly attenuated prior incubation tissues with SAIMR (0.864 µg/µL; 67% 4%; P < 0.05; n 3–5, unpaired t-test). Addition at t50 failed prevent further inhibition...
Abstract Research into Australian elapid venoms has mainly focused on the seven genera of greatest clinical significance: A canthophis, H oplocephalus , N otechis O xyuranus, P seudechis seudonaja and T ropidechis . However, even small species represent a potential for causing severe envenoming. Further, owing to taxonomic distinctiveness, these are source novel toxins use in drug design development. This is first study characterize C ryptophis boschmai D enisonia devisi E chiopsis curta...