A5047028813- 3D Surveying and Cultural Heritage
- Archaeological Research and Protection
- Remote Sensing and LiDAR Applications
- Wildlife Ecology and Conservation
- Lymphoma Diagnosis and Treatment
- Species Distribution and Climate Change
- Chronic Lymphocytic Leukemia Research
- Remote Sensing in Agriculture
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Viral-associated cancers and disorders
- S100 Proteins and Annexins
- Wind Energy Research and Development
- Immunotherapy and Immune Responses
- Escherichia coli research studies
- Forest Management and Policy
- Integrated Energy Systems Optimization
- Water Quality Monitoring and Analysis
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- CNS Lymphoma Diagnosis and Treatment
- Remote-Sensing Image Classification
- Wildlife-Road Interactions and Conservation
- Image Processing and 3D Reconstruction
Fudan University
2023-2024
Soochow University
2022-2024
First Affiliated Hospital of Soochow University
2022-2024
Chinese Academy of Sciences
2014-2023
International Centre on Space Technologies for Natural and Cultural Heritage
2018-2023
Aerospace Information Research Institute
2023
University of Twente
2019-2023
Northeast Forestry University
2023
Beijing Institute of Big Data Research
2023
Shanghai Institute of Materia Medica
2020-2022
The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, has been considered as drug target for chronic inflammatory diseases. A variety of peptides with different structures origins have characterized FPR2 ligands. However, the ligand-binding modes remain elusive, thereby limiting development potential drugs. Here we report crystal structure bound to potent agonist WKYMVm at 2.8 Å resolution. adopts an active conformation exhibits deep pocket....
Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of β amyloid Aβ42 and serves as a for humanin, that protects neuronal cells from damage by Aβ42, implying its involvement in pathogenesis Alzheimer's disease (AD). However, interaction pattern between FPR2 or humanin remains unknown. Here we report structures bound Gi N-formyl (fHN). Combined with functional data, reveal two critical regions govern recognition activity fHN, including polar binding cavity within...
This study mainly focuses on revealing an ancient water landscape at the Longcheng site in northern Chaohu Lake Basin using very high-resolution (VHR) GeoEye-1 imagery. First, prior to classification, image was processed following atmospheric and geometric correction. The supervised classification carried out order show land-cover situation area. overall accuracy 89.98%, with a kappa coefficient of 0.87. moat system around city walls discovered by rule-based object-oriented segmentation...
Visibility (or viewshed) analysis, a common function in geographical information systems, is used wide range of fields such as urban planning, landscape management, and ecological research. However, measuring fine-scale visibility within forest environment challenging due to the structural complexity plant architecture. Here we propose new method for estimating forests using terrestrial laser scanning (TLS). We compare plots derived from TLS with that gold standard photography-based approach...
Visibility is a key factor influencing animal behavior in forest ecosystems. Fine-scale visibility forested areas has been measured by ground-based approaches at the plot level, using site-specific methods that have limited spatial coverage. Here we examine airborne laser scanning (ALS) as novel tool to quantify fine-scale temperate forests of Germany landscape scale. We validate (vertically-derived) ALS-derived measures proven (horizontally-derived) terrestrial (TLS) estimates true...
Abstract Visibility (viewshed) plays a significant and diverse role in animals' behaviour fitness. Understanding how visibility influences animal requires the measurement of habitat at spatial scales commensurate to individual choices. However, measuring fine scale over landscape is challenge, particularly highly heterogeneous landscapes (e.g. forests). As result, our ability model influence fine‐scale on has been impeded or limited. In this study, we demonstrate application concept...
Red fluorescent proteins (RFPs) have broad applications in life science research, and the manipulation of RFPs using nanobodies can expand their potential uses. However, structural information available for that bind with is still insufficient. In this study, we cloned, expressed, purified, crystallized complexes formed by mCherry LaM1, LaM3, LaM8. Then, analyzed biochemical properties mass spectrometry (MS), fluorescence-detected size exclusion chromatography (FSEC), isothermal titration...
Expert knowledge is a combination of prior information and subjective opinions based on long-experience; as such it often not sufficiently objective to produce convincing results in animal habitat suitability index mapping. In this study, an assessment method learning neural network proposed reduce the level subjectivity assessments. Based two hypotheses, substitutes with apparent density has advantages over conventional ones those analytical hierarchy process or multivariate regression...
This paper is focused on the joint use of non‐invasive and minimal intervention techniques for supporting archaeological prospection. Very high resolution (VHR) satellite imagery analysis ground‐penetrating radar (GPR) boring surveys were integrated study Longcheng site, located near Hefei city in Anhui Province, China, to test their effectiveness efficiency prospecting remains evaluating degree preservation. First, target locations potential structures identified a WorldView‐2 (WV‐2) image...
The data driven is one of the main methods for forecasting algae bloom, which requires lots continuous and accurate monitoring data. It an effective way to increase sample size by combining in-situ, remote sensing Chaohu Lake was taken as case study. Based on water quality (TLI), meteorological (sunshine duration, temperature, wind speed, direction) bloom grade data, provided respectively in-situ monitoring, artificial neural network employed build empirical data-driven models. model...
Background: Preclinical trial has demonstrated that sequential use of Selinexor and Anti-CD19 directed chimeric antigen receptor modified T-Cell therapy (CART19) cells might improve the anti-tumor efficacy CART 19 against lymphoma cells. However, safety CART19 combined with in patients is unknown. We report preliminary data from a phase 2 relapsed or refractory B-cell non-Hodgkin (R/R B-NHL). Methods: performed multicenter, prospective, II, open-label clinical study R/R B-NHL. Patients...
To explore the clinical and pathological characteristics as well therapies prognosis of gray zone lymphoma (GZL). The data 10 GZL patients admitted to First Affiliated Hospital Soochow University from December 2016 2022 were retrospectively collected. characteristics, analyzed. cut-off time for follow-up visits was 31, 2022, median [
Background: Approximately one-third of Diffuse large B-cell lymphoma(DLBCL) arises primarily from extranodal sites,less than 70% showed involvement in at least 1 site.Patients with multiple indicates adverse clinical outcomes,and non-GCB subtype is another poor prognostic factor.Study shows that the rates complete remission(CR),five-year OS,five-year PFS were significantly lower for subtype(77.5% vs 52.6%,78% 54%,76% 48%).Patients who failed initial treatment had prognosis and short overall...
Objective: This study aimed to compare the efficacy and safety of cladribine, smustine, etoposide, cyclophosphamide, cytarabine (C+SCAV) cytarabine, melphalan (SEAM) conditioning regimens in autologous stem cell transplantation (auto-HSCT) for non-Hodgkin's lymphoma (NHL) . Methods: A retrospective analysis was conducted on 61 NHL patients who received auto-HSCT Department Hematology, First Affiliated Hospital Suzhou University, from March 2018 May 2021. The C + SCAV group SEAM had 19 42...
Si, dans le cas du radiodiagnostic, les limites de dose individuelles ne s'appliquent pas à l'exposition des patients, l'optimisation la radioprotection peut, par contre, jouer un rôle important. L'utilisation principe d'optimisation a guidé ce projet visant améliorer, en Chine, protection patients lors pratique radiodiagnostic médical. Notre enquête, réalisée régions Sichuan, Shandong et Pékin (Chine), évalué situation actuelle patients. Les doses aux ont été classées réelle, justifiée...