A5036072292- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- RNA regulation and disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Mercury impact and mitigation studies
- Drug-Induced Ocular Toxicity
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Transition Metal Oxide Nanomaterials
- Corneal surgery and disorders
- CRISPR and Genetic Engineering
- Ocular Surface and Contact Lens
- Ocular Disorders and Treatments
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Health Research
- Complement system in diseases
- Ocular Oncology and Treatments
- Cellular transport and secretion
Universidad de Valladolid
2015-2024
Junta de Castilla y León
2022-2024
Instituto de Salud Carlos III
2017-2024
Spanish Clinical Research Network
2022
Comunidad de Madrid
2021
Hospital Universitario Río Hortega
2008-2020
Hospital Clínico Universitario de Valladolid
2018
University College London
2002
Moorfields Eye Hospital
2002
Universitat de Barcelona
2002
A series of recent acute blindness cases following non-complicated retinal detachment surgery caused the release several health alerts in Spain. The was attributed to certain lots perfluoro-octane (PFO; a volatile and transient medical device). Similar have been reported other countries. This has raised questions regarding validity cytotoxicity test methods currently used certify safety PFO lots. tests were performed according International Organization for Standardization (ISO) norms, using...
<h3>Aims:</h3> To compare anatomical and functional outcomes for 546 phakic pseudophakic primary rhegmatogenous retinal detachments (RDs) treated by pars plana vitrectomy or scleral buckling. <h3>Methods:</h3> Prospective, non-randomised, interventional study in 15 centres Spain Portugal, with data from RDs consecutively January 2005 to May 2007. Cases preoperative proliferative vitreoretinopathy grade C-1 higher perforating trauma were excluded. Minimum follow-up was 3 months. Twenty-seven...
To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use toxic perfluoro-octane (PFO). The clinical presentation is described, and the likely causes are analyzed. New biological methods for testing safety medical devices proposed.Information regarding eyes suffering events PFO was Four types spectroscopy, nuclear magnetic resonance, chromatography were used to identify potential contaminants. Cultures human pigment epithelial cells (ARPE-19) porcine...
To evaluate the prevalence of and describe pathology associated with macular bending (MB) defined as a smooth elevation found in optical coherence tomography (OCT) patients high myopia related to either dome-shaped macula (DSM) or border an inferior staphyloma.We reviewed 330 files all highly myopic our database that had OCT performed last 5 years. Main outcome measures were MB its pathology.Sixty-eight eyes from 45 (13.63%) presented MB; 23 bilateral, 40 posterior pole staphyloma 21...
<h3>Aims:</h3> To assess variations in the characteristics and management of two series non-complicated rhegmatogenous retinal detachments (RD) carried out 4 years apart Spain. <h3>Methods:</h3> Prospective, multicentric, non-randomised comparative study. 339 consecutive cases RD treated five hospitals were included. Group 1 (G1) (n = 186) included operated on from 1999 to 2001; group 2 (G2) 153) 2004 2006. 83 variables related preoperative RD, surgical postoperative evolution recorded....
Purpose: To evaluate the efficacy of different anesthetics and topical anti-inflammatory treatment in patients undergoing intravitreal injections (IVI).Methods: Prospective, randomized, double masked, comparative study. Patients 0.05 mL IVI were randomized to two preoperative anesthetic regimes (regime A [0.5% tetracaine + naphazoline] versus regime B [5% lidocaine]) post-injection protocols (protocol 1 [tobramycin qid] protocol 2 qid diclofenac qid]). trained score pain using a numerical...
The complement factor H (FH) mutation R1210C, which was described in association with atypical hemolytic uremic syndrome (aHUS), also confers high risk of age-related macular degeneration (AMD) and associates C3 glomerulopathy (C3G). To reveal the molecular basis these associations to provide insight into what determines disease phenotype FH-R1210C carriers, we identified carriers our aHUS, C3G, AMD cohorts. Disease status, determined patients relatives, revealed an absence phenotypes aHUS...
To report the major intraretinal pathological changes in retinas with proliferative vitreoretinopathy (PVR) and retinal shortening, 13 human samples from postoperative PVR after primary surgery for detachment were immunostained vimentin, glial fibrillary acidic protein (GFAP), cytokeratins, CD68. One more sample was studied electron microscopy. Retinal disorganization, neuronal loss, gliosis observed 12 out of samples, but all positive GFAP. Müller cell processes showed different degrees...
In Brief Background: Torpedo maculopathy, also called solitary hypopigmented nevus, is a rare though benign disorder. To our knowledge, there are no previous optical coherence tomography (OCT) descriptions in the literature. Methods: Results of ophthalmologic examinations (including retinography, OCT, and visual field testing) for 2 girls aged 12 years 13 throughout 5 follow-up were reviewed. Results: both cases, anterior posterior segment evaluation was unremarkable except presence flat,...
Over 175 pathogenic mutations in the Peripherin-2 (PRPH2) gene are linked to various retinal diseases. We report phenotype and genotype of eight families (24 patients) with diseases associated seven distinct PRPH2 mutations. identified a new mutation, c.824_828+3delinsCATTTGGGCTCCTCATTTGG, patient adult-onset vitelliform macular dystrophy (AVMD). One family p.Arg46Ter mutation presented already described AVMD phenotype, but another same two heterozygous (p.Leu2027Phe p.Gly1977Ser) ATP...
Abstract Background Inherited retinal dystrophies (IRD) are one of the main causes incurable blindness worldwide. IRD caused by mutations in genes that encode essential proteins for retina, leading to photoreceptor degeneration and loss visual function. generates an enormous global financial burden due lack understanding a significant part its pathophysiology, molecular diagnosis, near absence non-palliative treatment options. Patient-derived induced pluripotent stem cells (iPSC) seem be...
The Pattern Electroretinogram (PERG) is an essential tool in ophthalmic electrophysiology, providing objective assessment of the central retinal function. It quantifies activity cells macula and ganglion retina, assisting differentiation macular optic nerve conditions. In this study, we present IOBA-PERG dataset, extensive collection 1354 transient PERG responses accessible on PhysioNet repository. These recordings were conducted at Institute Applied Ophthalmobiology (IOBA) University...
<b><i>Purpose:</i></b> To study whether anti-vascular endothelial growth factor (VEGF) therapy improves visual acuity (VA) in patients with exudative age-related macular degeneration (AMD) complicated retinal pigment epithelium (RPE) tears. <b><i>Methods:</i></b> Retrospective case-control series. Group I (control group) included 9 RPE tears that received no treatment, and group II (intervention incorporated 12 treated anti-VEGF....
Purpose: To analyze the distribution of inherited retinal diseases (IRDs), describe clinical characteristics patients, and determine percentages patients with genetic diagnosis in Castilla y Leon region Spain. Methods: All an IRD seen two major referral units during a 20-year period were included. The ages at symptom onset, diagnosis, last visit; sex; family history; history consanguinity; type inheritance; status fundus electroretinogram findings; lens macular status, visual acuity; field...
Background: The burden of illness, including health resource utilization and costs associated with bilateral neovascular age-related macular degeneration (Nv-AMD), was assessed in Spain.Patients methods: As part an international prospective, case-controlled study, 89 Spanish patients Nv-AMD were recruited by retina specialists 96 control subjects general practitioners ophthalmologists. Physicians recorded clinical data visual acuity (VA). In a subsequent telephone interview, controls...
To assess the occurrence of PRPH2 mutations in patients presenting macular dystrophies and to describe their phenotype-genotype correlation.A total 32 sporadic cases 13 individuals from 5 families were studied. The presented early onset drusen, suspected pattern dystrophy (including adult-onset foveomacular vitelliform [AOFVD]), or any presumed producing neovascularization atrophic changes documented before reached 50 years age. In case atrophy, this could be confined macula, which was...
Aims To report new information related to acute retinal toxicity of Bio Octane Plus, a mixture 90% perfluorooctane (PFO) and 10% perfluorohexyloctane. Methods This retrospective, descriptive case series reports the occurrence after vitreoretinal surgery in which Plus (batch number 1605148) was used as an endotamponade. Cytotoxicity biocompatibility tests chemical analyses by Fourier-transformed infrared (FTIR) spectroscopy gas chromatography-mass spectrometry (GC-MS) presumed toxic product...
To evaluate the treatment of subfoveal and juxtafoveal choroidal neovascularization (CNV) using verteporfin photodynamic therapy (vPDT) in patients affected by punctate inner choroidopathy (PIC).A chart review 8 with CNV associated PIC treated vPDT was done.The (8 eyes) included 4 men women a mean age 30.9 years. Six them presented CNVs, two had at presentation. Mean follow-up time 22.7 months. The VA improved five eyes, three eyes declined. One patient developed new few days after vPDT, one...