Abstract Background Drug and contrast agent delivery systems that achieve controlled release in the presence of enzymatic activity are becoming increasingly important, as is a hallmark wide array diseases, including cancer atherosclerosis. Here, we have synthesized clusters ultrasmall superparamagnetic iron oxides (USPIOs) sense for applications magnetic resonance imaging (MRI). To this goal, utilize amphiphilic poly(propylene sulfide)- bl -poly(ethylene glycol) (PPS-b-PEG) copolymers, which...

Gold nanoparticles (AuNPs) were functionalized for rapid binding of Acinetobacter baumannii (A. baumannii), a Gram-negative bacterium. AuNPs with colistin (Col), polycationic antibiotic, using two-step self-assembly process, in which heterobifunctional polyethylene glycol (PEG) was used as linker. Colistin successfully conjugated to the (Col-PEG-AuNP), validated by dynamic light scattering (DLS) and proton nuclear magnetic resonance (H1 NMR). High angle annular dark field scanning...

Acinetobacter baumannii is a Gram-negative bacterium of increasing concern due to its virulence and persistence in combat healthcare environments. The incidence both community-acquired nosocomial A. infections on the rise foreign domestic facilities. Treatment options are limited acquisition multidrug resistance few effective antibiotics. Currently, most pharmaceutically based treatment for multidrug-resistant antibiotic colistin (polymyxin E). To minimize side effects associated with...

As quantum dot (QD) bioconjugates are increasingly being used for biomedical in vitro and vivo studies, validated methods the quantitative determination of QD concentration considerable potential value. In this work, we have assessed inductively coupled plasma mass spectrometry (ICP-MS) as a method detection QDs bioconjugates. We established linear relationship between unconjugated cadmium, selenium zinc detected by ICP-MS. Furthermore, ICP-MS was to quantitatively estimate unknown...

The rise of multi-drug resistance has decreased the effectiveness antibiotics, which led to increased mortality rates associated with symptomatic bacteremia, or bacterial sepsis. To combat decreasing antibiotic effectiveness, extracorporeal separation approaches have been proposed capture and separate bacteria from blood. However, bacteremia is dynamic involves host-pathogen interactions across various anatomical sites. We developed a mathematical model that quantitatively describes kinetics...

The frontispiece features the multistrata nanoparticle—a single-core, five-layered nanostructure. It combines tunable, dual-peak, UV–vis–NIR spectrum extinction characteristics; trimodal imaging contrast; a simple synthesis; and facile surface modification capabilities into single <60-nm-diameter, multifunctional nanosphere that seeks to relieve current methodological limitations by coupling diagnostics therapeutics one theranostic tool. image shows model of interior, multilayered,...

ABSTRACT Introduction Bacterial sepsis is a life-threatening disease and significant clinical problem caused by host responses to microbial infection. Sepsis leading cause of death worldwide and, importantly, morbidity mortality in combat settings, placing considerable burden on military personnel health budgets. The current method treating restricted pathogen identification, which can be prolonged, antibiotic administration, is, initially, often suboptimal. trials that have been performed...

Bacteremia and related syndromes such as sepsis septic shock are becoming an increasing health concern due in large part to the rise of antibiotic resistance unmet challenges for rapid diagnosis.Extracorporeal bacterial separation methods currently under development identify pathogens reduce load.Previous studies have generated models understand progression bacteremia.Here, a physiologically-based pharmacokinetic model was integrated with physically-based magnetic inform design micromagnetic...

Bacteremia and related syndromes such as sepsis septic shock are becoming an increasing health concern due in large part to the rise of antibiotic resistance unmet challenges for rapid diagnosis.Extracorporeal bacterial separation methods currently under development identify pathogens reduce load.Previous studies have generated models understand progression bacteremia.Here, a physiologically-based pharmacokinetic model was integrated with physically-based magnetic inform design micromagnetic...

Abstract NOTE: The first page of text has been automatically extracted and included below in lieu an abstract Nanoparticle Synthesis to Application: a Nanobiotechnology Lab Course for Biomedical Engineering Introduction investigation living systems using nanoscale technologies evolved into new field research, bionanotechnology. Bionanotechnology is the development novel technology at level that used interface with biological systems. This highly interdisciplinary area integrates knowledge...