A5057093910- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Viral-associated cancers and disorders
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Nonmelanoma Skin Cancer Studies
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Ocular Oncology and Treatments
- Anesthesia and Pain Management
- Nausea and vomiting management
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
- Protein Degradation and Inhibitors
- Cystic Fibrosis Research Advances
Massachusetts Eye and Ear Infirmary
2024
Harvard University
2024
Banner MD Anderson Cancer Center
2021
The University of Texas MD Anderson Cancer Center
2021
Arizona Oncology
2016-2017
Loyola University Medical Center
2009-2015
Loyola University Chicago
2012
Rush University Medical Center
2006-2008
Uncontrolled delayed nausea and vomiting remains a problem after high-dose preparative regimens used for autologous allogeneic hematopoietic stem cell transplants. Recently, aprepitant was approved highly moderately emetogenic chemotherapy, and, in particular, is effective decreasing emesis. To evaluate its safety efficacy the transplantation setting, we performed randomized, placebo-controlled, phase 3 trial of combination with ondansetron dexamethasone patients treated ablative regimens....
An unusual case of cutaneous angiosarcoma clinically mimicking eczema is described. A 98-year-old Caucasian male presented with a 6-month history flesh-colored, subcutaneous nodule on his left forehead contralateral facial erythema and scaling that had been previously diagnosed as eczema. Despite treatments topical steroids moisturizers, the condition did not resolve. At our clinic, excisional biopsy lesion scouting biopsies from cheek were performed which revealed angiosarcoma. The...
Purpose: To determine whether the availability of a cytopathology-confirming diagnosis is correlated with prognostic accuracy gene expression profiling assay. Methods: A single-center retrospective review was performed patients diagnosed uveal melanoma who had fine-needle aspiration biopsy and before proton therapy from 2012 to 2020. The development metastases compared in cytopathology (gene profiling+cytopathology group) only group). Results: Of 141 profiling, 98 (69.5%) results 43 (30.5%)...
Surveillance frequency for metastasis is guided by gene expression profiling (GEP). This study evaluated the effect of GEP on time to diagnosis metastasis, subsequent treatment and survival. A retrospective was conducted 110 uveal melanoma patients with (DecisionDx-UM, Castle Biosciences, Friendswood, Texas, USA) American Joint Committee Cancer-matched controls. testing were compared between two groups class. Rates overall survival melanoma-related mortality calculated using Kaplan–Meier...
Abstract Allogeneic transplant using reduced intensity conditioning is a therapeutic option for patients with Hodgkin lymphoma (HL) who relapse after an autograft. This was prospective study of 31 consecutive eligible HL relapsed autograft and underwent allograft BEAM (BCNU, etoposide, cytarabine, melphalan) conditioning. At median follow-up 7 years the progression-free survival (PFS) 36% (95% confidence interval [CI] 19-54%) overall (OS) 42% CI 23-59%). In multivariate analysis only...
Donor cell derived malignancies are a rare and interesting complication of allogeneic bone marrow transplantation. We present case 56-year-old male with donor myeloid sarcoma the stomach myocardium.
10046 Background: The SIPAT is used to assess psychosocial risk in solid organ transplants but data HSCT lacking. We examined if pre-HSCT scores predict mortality, morbidity, length of stay (LOS) and number hospitalizations over a 1 year period. Methods: 89 adult (59% autologous, 38% allogeneic) pts from an academic medical center underwent the pre-HSCT. Additional were obtained on Day 0, 3-, 6-, 12-months. Univariable Cox proportional hazards models assessed instantaneous mortality at any...
ASCT remains the standard of care for newly diagnosed MM. Recent studies have demonstrated that although STUR is improving across all ethnicities, it lowest in Black (B) and Hispanic (H) populations relative to Caucasians(C). New data suggests differences utilization are not secondary outcome among different ethnicities. We reviewed our on patients seen consult a potential first transplant MM, attempt understand why where fail undergo transplantation. From Nov 2011 June 2016 we assessed 388...
(R,R′)-4′-Methoxy-1-naphthylfenoterol (MNF) promotes growth inhibition and apoptosis of human HepG2 hepatocarcinoma cells via cannabinoid receptor (CBR) activation. The synthetic CB1R inverse agonist, AM251, has been shown to block the anti-mitogenic effect MNF in these cells; however, AM251 is also an agonist recently deorphanized, lipid-sensing receptor, GPR55, whose upregulation contributes carcinogenesis. Here, we investigated role GPR55 signaling PANC-1 cancer cell lines culture by...
Sarcoma originating from the pulmonary veins represents one of rarest subtypes sarcoma. We report case a 52-year-old woman presenting with cough and scant hemoptysis ultimately diagnosed primary intimal sarcoma left inferior vein extending into lower lobe lung. To our knowledge, this is first reported such pathology in literature. present critically appraise literature for sarcomas great vessels.
Autologous peripheral blood stem cell (PBSCT) transplant is considered standard therapy for Multiple myeloma (MM). GCSF started on day +1, historically had been used to expedite engraftment. More recent studies have demonstrated that initiating later during does not delay engraftment and reduces costs. As part of our QA policy we routinely look cost savings improvements clinical practice. One such potential enhancement was determine in MM patients if could safely discontinue G post since...
With the development of reduced intensity options, allogeneic transplant is increasingly being used in patients over age 60. Although early TRM has been decreased, there are still substantial complications with graft versus host disease (GVHD). Recent data post Cytoxan shown to allow safe substantially lower risks GVHD haplo-identical transplants. As part a quality review we noted that our and mortality 60 was very high using standard dose tacrolimus methotrexate (TM). We made programmatic...
There are no international guidelines on how the requirements for added clinical value (endpoints) should be prepared in terms of drug safety by entities performing health technology assessments (HTAs). The study aimed to review Danish Medicines Council's endpointsSafety endpoints expert committees were reviewed from their assessment reports 50 treatments, which 25 treatment cancer and other types diseases. Similarities differences identifiedThe 139 grouped into 14 categories. use varied all...
Secondary acute myeloid leukemia (sAML) and AML with myelodysplasia-related changes (AML-MRC) both result in dismal outcomes. This retrospective study aimed to determine whether these features are poor prognostic factors independent of older age adverse cytogenetics, which commonly associated a prognosis.The characteristics real-world outcomes sAML AML-MRC from the Thai registry database were investigated.From total 992 newly diagnosed patients, 315 (31.8%) patients classified into or...