A5039299788- Erythrocyte Function and Pathophysiology
- Lipid Membrane Structure and Behavior
- Nanopore and Nanochannel Transport Studies
- 3D Printing in Biomedical Research
- Neonatal Health and Biochemistry
- Blood properties and coagulation
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Enzyme Catalysis and Immobilization
- Long-Term Effects of COVID-19
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Anodic Oxide Films and Nanostructures
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Vitamin C and Antioxidants Research
- biodegradable polymer synthesis and properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanofabrication and Lithography Techniques
- Molecular Junctions and Nanostructures
- Sphingolipid Metabolism and Signaling
- Immune Cell Function and Interaction
- Advanced Polymer Synthesis and Characterization
Regeneron (United States)
2024
Ohio University
2020
Cleveland State University
2016-2020
Abstract The plasma membrane of eukaryotic cells is asymmetric with respect to its phospholipid composition. Analysis the lipid composition outer leaflet important for understanding cell biology in health and disease. Here, a method based on cyclodextrin-mediated exchange characterize phospholipids red blood (RBCs) reported. Methyl-α-cyclodextrin, loaded exogenous lipids, was used extract from leaflet, while delivering lipids maintain integrity. Thin layer chromatography lipidomics...
Recent human genome-wide association studies have identified common missense variants in MARC1 , p.Ala165Thr and p.Met187Lys, associated with lower hepatic fat, reduction liver enzymes protection from most causes of cirrhosis. Using an exome-wide study we recapitulated earlier p.Met187Lys findings 540,000 individuals five ancestry groups. We also discovered novel rare putative loss function a phenotype similar to p.Ala165Thr/p.Met187Lys variants. In vitro recombinant protein revealed...
Eryptosis, erythrocyte programmed cell death, occurs in a number of hematological diseases and during injury to erythrocytes. A hallmark eryptotic cells is the loss compositional asymmetry membrane, leading translocation phosphatidylserine membrane outer leaflet. This process triggered by increased intracellular concentration Ca2+, which activates scramblase, an enzyme that facilitates bidirectional movement phospholipids between leaflets. Given importance eryptosis various diseased...
Plasma lipid levels are modulated by systemic infection and inflammation; it is unknown whether these changes reflect inflammatory responses or caused directly pathogen presence. We explored the hypothesis that anti-inflammatory intervention via interleukin 6 receptor (IL-6R) blockade would influence plasma during severe evaluated association of with clinical outcomes. Sarilumab (monoclonal antibody blocking IL-6R) efficacy was previously assessed in patients coronavirus disease 2019...
Disruption of plasma membrane integrity is a primary mechanism nanoparticle toxicity in cells. Mechanistic studies on nanoparticle-induced damage have been commonly performed using model membranes with focus symmetric bilayers, overlooking the fact that has an asymmetric phospholipid composition. In this study, erythrocytes normal and scrambled asymmetry were utilized to examine how loss resulting alterations outer leaflet lipid composition affect nanoparticle-membrane interactions....
Eryptosis, erythrocyte programmed cell death, occurs in a number of hematological diseases and during injury to erythrocytes. A hallmark eryptotic cells is the loss compositional asymmetry membrane, leading translocation phosphatidylserine membrane outer leaflet. This process triggered by increased intracellular concentration Ca2+, which activates scramblase, an enzyme that facilitates bidirectional movement phospholipids between leaflets. Given importance eryptosis various diseased...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)