A5089869813- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Silymarin and Mushroom Poisoning
- Acute Kidney Injury Research
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
Tabriz University of Medical Sciences
2016-2019
University of Tabriz
2019
Context: Multiple drug resistance is the major obstacle to conventional chemotherapy. Silibinin, a nontoxic naturally occurring compound, has anticancer activity and can increase cytotoxic effects of chemotherapy in various cancer models.Objective: To evaluate silibinin on enhancing sensitivity chemo-resistant human breast cell lines doxorubicin (DOX) paclitaxel (PAC).Materials methods: The cells were treated with (at 50 600 μM concentrations) and/or chemo drugs for 24 48 h, then viability...
Introduction: Silibinin is a naturally occurring compound with known positive impacts on prevention and treatment of many types human illnesses in general cancer particular. poorly water soluble which results its insufficient bioavailability lack therapeutic efficacy cancer. Here, we proposed to examine the potential micelles composed poly(ethylene glycol) (PEG) as hydrophilic block poly(ε-caprolactone) (PCL), poly(α-benzylcarboxylate-ε-caprolactone) (PBCL), or poly(lactide)-(PBCL)...