About
Contact & Profiles
A5052827586
Research Areas
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
Lehman College
2018
City University of New York
2018
We describe the synthesis of C-5 indole-tagged pyrimidine and C-8 purine nucleoside phosphoramidites their incorporation into double-stranded DNA 15 base pairs in length. Of 23 sequence modifications tested, two induced duplex to adopt a Z-like left-handed conformation under physiological salt conditions, bypassing specific sequences typically required for Z-DNA structure. The impact these varied with linker type: flexible propyl linkers exhibited distinct effects compared rigid propargyl...
10.1101/2025.01.26.634936
preprint
EN
bioRxiv (Cold Spring Harbor Laboratory)
2025-01-26
10.1016/j.tetlet.2018.12.018
article
EN
Tetrahedron Letters
2018-12-08
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