A5033026625- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Computational Drug Discovery Methods
- Anesthesia and Neurotoxicity Research
- HIV Research and Treatment
- Prion Diseases and Protein Misfolding
- Amino Acid Enzymes and Metabolism
- Advanced battery technologies research
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
Shenzhen Institutes of Advanced Technology
2023-2024
Chinese Academy of Sciences
2023-2024
German Center for Neurodegenerative Diseases
2016-2023
Ludwig-Maximilians-Universität München
2016-2018
Munich Cluster for Systems Neurology
2016-2018
The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases risk for late onset Alzheimer's disease. Mouse models accurately reproducing phenotypes observed in Alzheimer' disease patients carrying coding are required to understand TREM2 related dysfunctions responsible enhanced A CRISPR/Cas9-assisted gene targeting strategy was used generate Trem2 knock-in mice. mRNA and protein levels as well splicing patterns were assessed these mice,...
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheimer's disease. Prolonged BACE1 inhibition interferes with structural and functional synaptic plasticity in mice, most likely by altering metabolism substrates. Seizure 6 (SEZ6) predominantly cleaved BACE1, Sez6 knockout mice share some phenotypes inhibitor-treated mice. We investigated whether SEZ6 involved inhibition-induced alterations.The function NB-360, novel blood-brain...
Triggering receptor expressed on myeloid cell 2 (TREM2), a cell-specific signaling molecule, controls essential functions of microglia and impacts the pathogenesis Alzheimer's disease other neurodegenerative disorders. TREM2 is also highly in tumor-associated macrophages different types cancer. Here, we studied whether influences glioma progression. We found gender-dependent effect growth wild-type (WT) animals injected with GL261-EGFP cells. Most importantly, promotes progression male but...
Abstract Dynamic synapses facilitate activity‐dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, mechanisms governing dynamic in adult brain are still largely unknown. Here, we demonstrate that cortex amyloid precursor protein knockout ( APP ‐ KO ) mice, spine formation and elimination were both reduced while overall density remained unaltered. When housed under environmental enrichment, mice failed to respond with an increase...
It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer's disease (AD), while gaseous anaesthetic xenon (Xe) exhibits many features a putative neuroprotective agent. Loss synapses is regarded one key cause dementia in AD. Multiple EGF-like domains 10 (MEGF10) phagocytic receptors which assists elimination by astrocytes. Here, we investigated how β-amyloid peptide 1-42 (Aβ1-42), Iso and Xe interact with MEGF10-dependent...
Abstract INTRODUCTION More robust non‐human primate models of Alzheimer's disease (AD) will provide new opportunities to better understand the pathogenesis and progression AD. METHODS We designed a CRISPR/Cas9 system achieve precise genomic deletion exon 9 in cynomolgus monkeys using two guide RNAs targeting 3′ 5′ intron sequences PSEN1 9. performed biochemical, transcriptome, proteome, biomarker analyses characterize cellular molecular dysregulations this model. RESULTS observed early...
Abstract TREM2, a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis Alzheimer’s disease other neurodegenerative disorders. TREM2 is also highly expressed in tumor-associated macrophages plays detrimental roles an experimental mouse sarcoma model. Here we studied whether influences glioma progression. We found sex- dependent effect TREM2: volume significantly attenuated TREM2- deficient male but not female mice injected with...