A5070895597- Calcium signaling and nucleotide metabolism
- PARP inhibition in cancer therapy
- Cell Image Analysis Techniques
- CRISPR and Genetic Engineering
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Genetic Neurodegenerative Diseases
McMaster University
2018-2024
Huntington disease (HD) is a genetic neurodegenerative caused by cytosine, adenine, guanine (CAG) expansion in the
Live-cell microscopy imaging typically involves the use of high-quality glass-bottom chambers that allow cell culture, gaseous buffer exchange and optical properties suitable for applications. However, commercial sources these can add significant annual costs to biology laboratories. Consumer products in three-dimensional printing technology, both Filament Deposition Modeling (FDM) Masked Stereo Lithography (MSLA), have resulted more biomedical research labs adopting devices prototyping...
Abstract Huntington disease (HD) is a genetic neurodegenerative caused by CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract huntingtin protein. Age at onset correlates repeat length but varies decades between individuals with identical lengths. Genome-wide association studies link HD modification DNA repair and mitochondrial health pathways. Clinical show elevated damage HD, even premanifest stage. A major node influencing PARP pathway. Accumulation...
Abstract Live-cell microscopy imaging typically involves the use of high-quality glass-bottom chambers that allow cell culture, gaseous buffer exchange and optical properties suitable for applications. However, commercial sources these can add significant annual costs to biology laboratories. Consumer products in three-dimensional printing technology, both Filament Deposition Modeling (FDM) Masked Stereo Lithography (MSLA), have resulted more biomedical research labs adopting devices...