A5076514001- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Calcium signaling and nucleotide metabolism
- Microfluidic and Bio-sensing Technologies
- PARP inhibition in cancer therapy
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- DNA Repair Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
McMaster University
2021-2024
Abstract Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form HTT. Both wildtype and disease-state HTT hetero-dimer with HAP40 unknown functional relevance. We demonstrate vivo cell models that cellular abundance are coupled. Integrating data 2.6 Å cryo-electron microscopy structure, cross-linking mass spectrometry, small-angle X-ray scattering, modeling, we provide near-atomic-level view HTT, its...
Huntington disease (HD) is a genetic neurodegenerative caused by cytosine, adenine, guanine (CAG) expansion in the
Live-cell microscopy imaging typically involves the use of high-quality glass-bottom chambers that allow cell culture, gaseous buffer exchange and optical properties suitable for applications. However, commercial sources these can add significant annual costs to biology laboratories. Consumer products in three-dimensional printing technology, both Filament Deposition Modeling (FDM) Masked Stereo Lithography (MSLA), have resulted more biomedical research labs adopting devices prototyping...
Abstract Huntington disease (HD) is a genetic neurodegenerative caused by CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract huntingtin protein. Age at onset correlates repeat length but varies decades between individuals with identical lengths. Genome-wide association studies link HD modification DNA repair and mitochondrial health pathways. Clinical show elevated damage HD, even premanifest stage. A major node influencing PARP pathway. Accumulation...
Live-cell microscopy imaging typically involves the use of high-quality glass-bottom chambers that allow cell culture, gaseous buffer exchange and optical properties suitable for applications. However, commercial sources these can add significant annual costs to biology laboratories. Consumer products in three-dimensional printing technology, both Filament Deposition Modeling (FDM) Masked Stereo Lithography (MSLA), have resulted more biomedical research labs adopting devices prototyping...
Abstract Live-cell microscopy imaging typically involves the use of high-quality glass-bottom chambers that allow cell culture, gaseous buffer exchange and optical properties suitable for applications. However, commercial sources these can add significant annual costs to biology laboratories. Consumer products in three-dimensional printing technology, both Filament Deposition Modeling (FDM) Masked Stereo Lithography (MSLA), have resulted more biomedical research labs adopting devices...