A5023308100- Hepatitis C virus research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Ethics in Clinical Research
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Liver Disease and Transplantation
- Biosimilars and Bioanalytical Methods
- Animal Virus Infections Studies
- Intensive Care Unit Cognitive Disorders
- Monoclonal and Polyclonal Antibodies Research
- Disaster Response and Management
- Viral Infections and Outbreaks Research
- Cytomegalovirus and herpesvirus research
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Galectins and Cancer Biology
Medizinische Hochschule Hannover
2014-2024
Paul Ehrlich Institut
2020-2022
National Cheng Kung University
2015
Hepatitis D virus (HDV) infection affects 15-20 million individuals worldwide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute liver disease control of viral replication in HDV infection. Immune cell frequencies phenotypes were determined 49 HDV-infected patients, 25 with hepatitis B monoinfection 18 healthy controls. T-cell proliferative cytokine-producing capacities analyzed by stimulation overlapping peptides spanning the large...
HCV clearance by current antiviral therapies improves clinical outcomes but falls short in eliminating the risk for hepatocellular carcinoma (HCC) emergence. As HCC immune surveillance establishment is vital control of neoplastic development and growth, we investigated its correlation with on-/post-treatment emergence, further analyzed influence viral eradication on this setup patients HCV-related liver cirrhosis.PBMC isolated at baseline longitudinally during therapy were tumor-associated...
The risk of developing HCC in chronically infected patients with AQ2 HCV liver cirrhosis is significantly elevated. This remains high even after a sustained virological response direct-acting antivirals. To date, disease-associated signatures NK cells indicating development are unclear.
Hepatitis C virus (HCV) readily sets up persistence in a large fraction of infected hosts. Mounting epidemiological and immunological evidence suggest that HCV's could influence immune responses toward unrelated pathogens vaccines. Nonetheless, the fundamental contribution inflammatory milieu during persistent HCV infection impacting cells specific for common such as CMV EBV has not been fully studied. As co-regulatory receptors PD-1, Tim-3, 2B4 have all shown to be vital regulating CD8(+) T...
Abstract Background & Aims Chronic inflammatory liver diseases are frequently associated with neuropsychiatric and cognitive dysfunctions. We hypothesized that symptomatic patients may show altered levels of soluble mediators ( SIM s) as well changes in immune cell phenotypes. Methods A comprehensive immune‐phenotyping including investigation 50 s ex‐vivo phenotypes NK ‐cells, CD 3+, 4+, 8+ regulatory T cells 40 viral autoimmune chronic was performed. The patients’ functions were...
The risk of hepatocellular carcinoma persists in some patients despite achieving sustained virologic response with current interferon-free direct-acting antiviral therapy for hepatitis C. subject an even higher this context has been reported and is currently being debated. quest understanding paradox relative to the dynamics inflammatory biomarkers cirrhosis receiving thus remains a importance.Here, we aimed at evaluating effects therapy-induced C cure on plasmatic markers systemic...
Abstract Background A stable, well-functioning and integrated national medicines regulatory system is a core component of health systems resilient against infectious disease outbreaks. In many low- middle-income countries, however, sizable gaps exist in the emergency preparedness framework authorities (NRAs). RegTrain-VaccTrain project Germany Ministry Health’s Global Health Protection Programme that contributes to global efforts aimed at strengthening such by providing technical support...
Development of safe and efficacious medicines in many sub-Sahara African countries remains hampered due to fragmented health research infrastructure ineffective regulatory oversight. To boost the latter area Clinical Trials (CT) Oversight (CTO), international programs Regional Centers for Regulatory Excellence (RCORE) initiatives offer various trainings help strengthen human resource capacity. Here, we aimed at evaluating training outcomes (at home-institution level) sponsored fellows one...
More than 50% of hepatitis C virus (HCV) infection in patients establishes persistence, however, the hepatic host factors involving transition from acute stage to chronicity have not yet been fully understood.In this study, a NS3/ 4A protease-based reporter system was implanted Huh7.5 cells, which viral replication/infection could be continuously quantified by secreted alkaline phosphatase (SEAP) medium.The cells supported cultivation HCV for hundreds days.According measurements...