A5040761336- Hepatitis C virus research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Intensive Care Unit Cognitive Disorders
- Diabetes and associated disorders
- Viral Infections and Outbreaks Research
University of Veterinary Medicine Hannover, Foundation
2024
Medizinische Hochschule Hannover
2018-2021
German Liver Foundation
2021
Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude specificity of virus-specific antibody T cell responses after TBE previously vaccinated subjects compared results with those unvaccinated patients study that received vaccination without VBT infection. Symptomatic TBEV infection induced to E protein non-structural 1 (NS1) as well...
Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody cell-mediated immune responses, shortly after infection, with manifestations, severity long-term outcome has been poorly investigated. In a cohort thirty early tick-borne (TBE) patients, we assessed the magnitude, specificity functional properties T-cell responses. These responses during disease...
Treatment with direct-acting antivirals (DAAs) in patients chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment acute virus (HCV) DAAs may normalize most SIMs.In this study, made use a unique cohort symptomatic who cleared HCV 6-week course ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay measuring 92 proteins.Profound SIM alterations observed patients, marked...
Tick-borne encephalitis (TBE) is a serious neurological disease caused by TBE virus (TBEV). Because antiviral treatment options are not available, vaccination the key prophylactic measure against TBEV infections. Despite availability of effective vaccines, cases breakthrough infections have been reported. The multienzymatic non-structural protein 3 (NS3) orthoflaviviruses plays an important role in polyprotein processing and replication. In present study, we evaluated NS3 as potential...
Abstract Background & Aims Chronic inflammatory liver diseases are frequently associated with neuropsychiatric and cognitive dysfunctions. We hypothesized that symptomatic patients may show altered levels of soluble mediators ( SIM s) as well changes in immune cell phenotypes. Methods A comprehensive immune‐phenotyping including investigation 50 s ex‐vivo phenotypes NK ‐cells, CD 3+, 4+, 8+ regulatory T cells 40 viral autoimmune chronic was performed. The patients’ functions were...
Recurrence or de novo infection of hepatitis C virus (HCV) after liver transplantation (LT) has been associated with progressive graft that can be improved by treatment novel direct‐acting antivirals. Cases rejection episodes have described during and HCV treatment. The evolution innate adaptive immune response cure LT is unknown. We studied 74 protein biomarkers in the plasma patients receiving antiviral therapy. In addition, deep phenotyping both myeloid lymphoid cell subsets peripheral...