A5011960890- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Pelvic and Acetabular Injuries
- Anorectal Disease Treatments and Outcomes
- Pediatric Urology and Nephrology Studies
- Hernia repair and management
- Bladder and Urothelial Cancer Treatments
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Infant Nutrition and Health
- Renal Diseases and Glomerulopathies
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Esophagitis
- Herpesvirus Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Pregnancy-related medical research
- Brucella: diagnosis, epidemiology, treatment
- Spine and Intervertebral Disc Pathology
- Hepatitis Viruses Studies and Epidemiology
- Antibiotic Use and Resistance
- Urological Disorders and Treatments
- Neurological Disorders and Treatments
- Shoulder Injury and Treatment
University College London
2013-2020
University College Hospital
2016-2020
University College London Hospitals NHS Foundation Trust
2018
Stepping Hill Hospital
2006
Bacterial urinary tract infections (UTI) are a major growing concern worldwide. Uropathogenic Escherichia coli has been shown to invade the urothelium during acute UTI in mice and humans, forming intracellular reservoirs that can evade antibiotics immune response, allowing recurrence at later date. Other bacterial species, such as Staphylococcus saprophyticus, Klebsiella pneumonia Salmonella enterica have also be invasive UTI. However, role of infection chronic causing more subtle lower...
What's known on the subject? and What does study add? Microscopic pyuria is widely used as a surrogate marker of infection, although there little data supporting its use in patients who present with non‐acute LUTS . The effects urinary storage, preservation, laboratory methods to enhance leucocyte detection, are also unclear. This large, prospective highlights poor performance dipstick urine analysis, direct microscopy, markers UTI A series analyses examine handling processing test...
Midstream urine (MSU) culture remains the gold standard diagnostic test for confirming urinary tract infection (UTI). We previously showed that patients with chronic lower symptoms (LUTS) below cutoff on MSU may still harbor bacterial and their antibiotic treatment was associated symptom resolution.
Adenosine-5′-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as surrogate marker infection (UTI). The optimum clinical sampling method for urinalysis not been established. We tested assessment symptoms, inflammation, validated methods practice. A prospective, blinded, cross-sectional observational study adult patients presenting with symptoms...
Lower urinary tract symptoms (LUTS) may be associated with chronic infection (UTI) undetected by routine diagnostic tests. Antimicrobial therapy might confer benefit for these patients. Over 10 years, we treated patients LUTS. Pyuria was adopted as the principal biomarker of infection. Urinary leucocyte counts were recorded from microscopy fresh midstream urine (MSU) samples. Antibiotics prescribed and prescription adjusted to achieve a measurable clinical response reduction in pyuria. We...
The paucity of long-term safety and efficacy data to support laparoscopic mesh sacrohysteropexy is noteworthy given concerns about the use polypropylene in pelvic floor surgery. This study aimed at determining incidence mesh-associated complications reoperation following this procedure.
Urinary dipsticks and culture analyses of a mid-stream urine specimen (MSU) at 105 cfu ml−1 known urinary pathogen are considered the gold standard investigations for diagnosing tract infection (UTI). However, reliability these tests has been much criticised they may mislead. It is now widely accepted that pyuria (≥1 WBC μl−1) detected by microscopy fresh unspun, unstained best biological indicator UTI available. We aimed to scrutinise greater potential symptoms analysis in detecting UTI....
To measure the effects of an unplanned, sudden cessation treatment in unselected group patients with chronic painful LUTS managed protracted antimicrobial and to report these observational data collected from a cross-over process.The imposition guideline resulted immediate antibiotic cohort microscopic pyuria. Patients were assessed before withdrawal, whilst off treatment, following reinstatement. Outcome measures included validated symptom score, enumeration urinary white cells...
Abstract Mesh-augmented pelvic floor surgery evolved to address the limitations of native tissue repair in reconstructive surgery. The development synthetic mid-urethral tape signalled a revolution treatment stress urinary incontinence, whilst use mesh abdominal apical prolapse may confer benefits over alternatives. However, these procedures can be associated with mesh-specific complications, underlining need for shared decision-making between physicians and patients prior Transvaginal...
Background: Laparoscopic mesh sacrohysteropexy has been established as an effective, safe, and popular technique to treat uterine prolapse. Nevertheless, recent controversies regarding the role of synthetic in pelvic reconstructive surgery have triggered a trend towards meshless procedures. Other laparoscopic native tissue prolapses techniques such uterosacral ligament plication sacral suture hysteropexy previously described literature. Objectives: To describe minimally invasive with...