A5014482959- Mesenchymal stem cell research
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Peripheral Artery Disease Management
- Electrospun Nanofibers in Biomedical Applications
- Muscle Physiology and Disorders
- Proteoglycans and glycosaminoglycans research
- Retinal and Optic Conditions
- Renal and Vascular Pathologies
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Retinoids in leukemia and cellular processes
Tel Aviv University
2008-2024
Tel Aviv Sourasky Medical Center
2008-2024
Sheba Medical Center
2009
Lymphocytes play an important role in the progression of atherosclerosis. Recently, hypoxia inducible factor-1 (HIF-1) was found to attenuate inflammation by regulating T cell activation and cytokine production. We studied effects overexpression HIF-1alpha ApoE knockout murine lymphocytes, on experimental atherosclerosis.ApoE-/- mice were submitted intravenous hydrodynamic injection empty plasmid or HIF-1alphaP564A (HIF-1alpha mutated stabilized construct). Robust expression evident spleen...
Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated potential adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying migration capacity ASCs in vitro their protective effect against RPE cell death under oxidative vivo . exhibited enhanced when exposed conditioned medium stressed obtained hydrogen peroxide. Migration-related axis SDF-1/CXCR4 was studied, upregulation SDF-1 CXCR4 detected. Moreover, ASCs’...
Tissue engineering is considered a promising approach to treating advanced degenerative maculopathies such as nonexudative age-related macular degeneration (AMD), the leading cause of blindness worldwide. The retina consists several hierarchical tissue layers, each which supported by layer underneath. Each these layers has different morphology and requires distinct conditions for proper assembly. In fact, prerequisite step assembly organization Advanced retinal includes other including...
The LIM-homeobox transcription factor islet-1 (Isl1) marks a cell population which gives rise to myocardial, pacemaker, endothelial and smooth muscle cells, are derived from the secondary heart field during embryogenesis. Isl1+ precursors have potential of self-renewal differentiation into endothelial, cardiomyocyte lineages. primary objective this study was determine whether retroviral gene delivery Isl1 cells mesenchymal stem (MSCs) could promote angiogenic vasculogenic properties. To end,...
Bone marrow stromal cells (BMSCs) contain progenitors capable of participating in postnatal angiogenesis. Hypoxia-inducible factors (HIFs) mediate endothelial activation by driving the expression multiple angiogenic factors. We explored potential HIF-1alpha and HIF-2alpha modification BMSCs, as a tool to improve cell-based therapy. BMSCs were retrovirally transduced express stable forms HIF-2alpha. and, greater extent, overexpression promoted differentiation lineage, evident CD31 Tie-2...
BackgroundAdipose tissue–derived mesenchymal stem cells (ASCs) can be isolated from subcutaneous fat harvested by tissue resection or liposuction.
Comparing between the visual outcomes and post operative complications of two surgical treatments for sub macular hemorrhage, pars plana vitrectomy with tissue plasminogen activator (tPA) injection procedure, pneumatic displacement submacular hemorrhage intravitreal tPA injection.
To evaluate visual and surgical outcomes in very elderly patients (above 85 years of age) undergoing pars plana vitrectomy (PPV).A single-center, retrospective study was carried out on the medical records 82 aged older who had undergone PPV from 2006 to 2013. Patients ranged age 86 99 years, with a mean 88.9 (±2.88). Visual results intraoperative postoperative complications were main outcome measures. improvement/worsening defined as at least ±0.1 logMAR change.Mean follow-up 7.25 months...
To examine whether ischemic retinal ganglion cells (RGCs) will be salvaged from cell death by human adipose-derived mesenchymal stem (ADSCs) in an organotypic retina model.Deprived of arterial oxygen supply, whole mice retinas were cultured as ex vivo cultures on insert membrane a 24-well plate. The therapeutic potential ADSCs was examined co-culture with retinas. seeded top the RGCs allowing direct contact, or at bottom well, sharing same culture media and paracrine activity. number...
Ranibizumab (Lucentis) is an antibody fragment developed against all fragments of vascular endothelial growth factor (VEGF) that was approved by the FDA for treating age-related macular degeneration (AMD). Bevacizumab, a full-length anti-VEGF use in colon cancer, non-FDA at this time but it widely used AMD. The purpose study to compare influence Bevacizumab and on angiogenesis vitro model.A model consisting H5V cells derived from murine hearts capillary (ECs) used. were treated with three...
Retinal degenerative diseases are one of the main causes complete blindness in aged population. In this study, we compared therapeutic potential for retinal degeneration human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or orbital (OASCs) due to their accessibility and mutual embryonic origin with tissue, respectively. OASCs were found protect RPE cell death demonstrated increase early precursor markers, while ABASCs showed a raise marker expression. Subretinal...
BACKGROUND AND OBJECTIVE: Retinal imaging can help differentiate retinoschisis (RS) from retinal detachment (RD). This study describes new sonographic features of RS using ultrasound biomicroscopy (UBM) and evaluates their diagnostic value. PATIENTS METHODS: Medical records subjects diagnosed with RD who underwent prior to intervention were reviewed. Images evaluated for shape (US) B-mode, as well presence intraretinal pillars, layers split, cysts on UBM. RESULTS: Of 48 eyes patients in the...
The LIM-homeobox transcription factor isl1 plays a crucial role during heart embryogenesis. Embryonic isl1+ precursors give rise to over two-thirds of the and its subsequent lineages: cardiac muscle, smooth muscle endothelium. Interestingly, subset Isl1+ progenitors remains embedded in postnatal heart. In current study, we investigated whether is expressed adult mesenchymal stem cells (MSCs), after experimental myocardial infarction (MI). Additionally, examined overexpression MSCs could...