A5027734940- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- Healthcare and Environmental Waste Management
- Lipid Membrane Structure and Behavior
- Combustion and Detonation Processes
- Infant Nutrition and Health
- Reproductive Biology and Fertility
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Microplastics and Plastic Pollution
- Moringa oleifera research and applications
- Combustion and flame dynamics
- Force Microscopy Techniques and Applications
- Thermochemical Biomass Conversion Processes
- Glycosylation and Glycoproteins Research
- Reproductive Health and Technologies
- Enterobacteriaceae and Cronobacter Research
- Cystic Fibrosis Research Advances
- Heavy metals in environment
- Sperm and Testicular Function
Federal Institute for Risk Assessment
2015-2018
Because of the rising application nanoparticles in food and food-related products, we investigated influence digestion process on toxicity cellular uptake silver for intestinal cells. The main components--carbohydrates, proteins fatty acids--were implemented an vitro to simulate realistic conditions. Digested undigested nanoparticle suspensions were used studies well-established Caco-2 model. Small-angle X-ray scattering was estimate particle core size, size distribution stability cell...
Silver nanoparticles are used in consumer products like food contact materials, drinking water technologies and supplements, due to their antimicrobial properties. This leads an oral uptake exposure of intestinal cells. In contrast other studies we found no apoptosis induction by surfactant-coated silver the cell model Caco-2 a previous study, although particles induced oxidative stress, morphological changes death. Therefore, this study aimed analyze molecular mechanism We global gene...
The breadth of applications nanoparticles and the access to food-associated consumer products containing nanosized materials lead oral human exposure such particles. In biological fluids dynamically interact with biomolecules form a protein corona. Knowledge about corona is great interest for understanding molecular effects particles as well their fate inside body. We used mass spectrometry-based toxicoproteomics approach elucidate mechanisms toxicity silver comprehensively characterize...
The elucidation of mechanisms underlying the cellular uptake nanoparticles (NPs) is an important topic in nanotoxicological research. Most studies dealing with silver NP provide only qualitative data about internalization efficiency and do not consider NP-specific dosimetry. Therefore, we performed a comprehensive comparison differently coated NPs comparable size different human intestinal Caco-2 cell-derived models to cover also influence mucus barrier uptake-specialized M-cells. We used...
Abstract Consumers are orally exposed to nanoparticulate or soluble species of the non‐essential element silver due its use in food contact materials as a additive. Potential toxicity nanoparticles has gained special scientific attention. A fraction ingested ionic particulate is taken up intestine and transported liver, where it may induce oxidative stress elicit subsequent adverse responses. Here, we present comprehensive analysis global proteomic changes induced human Hep G2...