A5086239980- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Organometallic Complex Synthesis and Catalysis
- Catalysts for Methane Reforming
- Botanical Research and Chemistry
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Biological Activity of Diterpenoids and Biflavonoids
- Organoboron and organosilicon chemistry
- Catalysis and Hydrodesulfurization Studies
- Synthetic Organic Chemistry Methods
- Nanomaterials for catalytic reactions
- Sulfur-Based Synthesis Techniques
Southern University of Science and Technology
2022-2024
Construction of C-N bond continues to be one part the most significant goals in organic chemistry because universal applications amines pharmaceuticals, materials and agrochemicals. However, E2 elimination through classic S
Hydroformylation (HF) or isomerization-hydroformylation (ISO-HF) represents the most direct and practical route for producing aldehydes on an industrial scale. To resolve issues of low activity, linear/branched (
A catalytic protocol for the iridium-catalyzed asymmetric hydrogenation (AH) of γ- or δ-hydroxy ketones to rapidly assemble various aliphatic enantioenriched tetrahydrofurans (THFs) tetrahydropyrans (THPs) is disclosed. wide range THFs THPs were obtained in high yields and excellent enantioselectivities (up 99% up 96.5:3.5 er). The dynamic kinetic resolution (DKR-AH) process was also achieved, simultaneously constructing THP scaffolds with two contiguous stereogenic centers...
Chlorohydrins and oxaheterocycles are synthetically valuable building blocks for diverse natural products therapeutic substances. A highly efficient Ir/f-phamidol-catalyzed asymmetric hydrogenation of ω-chloroketones was successfully developed, various chlorohydrins were obtained divergently with excellent yields enantioselectivities (up to >99% yield ee). Synthetic utilities this divergent transformation demonstrated by gram-scale synthesis key intermediates several enantiomerically...
The convergent total synthesis of ixabepilone and its analogues in a 13‐step longest linear sequence is reported. crucial chiral centers at challenging C3‐O, C8‐C C15‐N positions on the scaffold were installed via highly efficient asymmetric hydrogenations (up to 95% yield up 99% e.e.) all three fragments could be prepared gram scale. key aldol reaction bridges aldehyde keto with high exquisite diastereo control (8:1 d.r.). Finally, novel RCM conformationally controlled by bulky silyl group...
Abstract The precise and effective construction of challenging C-N bond continues to be one part the most significant goals in organic chemistry because universal applications amines containing bonds pharmaceuticals, materials as well agrochemicals. However, E2 elimination through classic SN2 substitution alkyl halides with nitrogen nucleophiles often occurs alkenes are generated major side-products especially when secondary or tertiary substrates employed. Thus, formation a C(sp3)-N on...