A5101896204- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Enzyme Catalysis and Immobilization
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Biochemical and Structural Characterization
- Maternal and Perinatal Health Interventions
- RNA and protein synthesis mechanisms
- Silk-based biomaterials and applications
- Linguistics and Cultural Studies
- Mobile Health and mHealth Applications
- Biotin and Related Studies
- Supramolecular Chemistry and Complexes
- Cellular transport and secretion
- Click Chemistry and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Social Media in Health Education
- Organoselenium and organotellurium chemistry
- Force Microscopy Techniques and Applications
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Molecular Communication and Nanonetworks
Hangzhou Normal University
2009-2024
National Institute for Parasitic Diseases
2021
Hangzhou Xixi hospital
2020
Nanjing University of Chinese Medicine
2019
Tianjin Economic-Technological Development Area
2019
Tianjin University of Science and Technology
2019
New York State Department of Health
2016
Wadsworth Center
2016
University of Michigan
2014
The University of Tokyo
2013
Significance Light-emitting materials have been widely studied for their promising applications in chemical and biological science. Here we report three phenanthrene-21-crown-7 functionalized fluorescent Pt(II) rhomboidal metallacycles which were then converted into supramolecular oligomers by reacting with a bis-ammonium linker. One of these constructs shows concentration-dependent fluorescence wide color range, where orange emission at high concentration blue low was observed. Moreover, 29...
A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates a selenosulfonate under mild conditions is disclosed.
Construction of C-N bond continues to be one part the most significant goals in organic chemistry because universal applications amines pharmaceuticals, materials and agrochemicals. However, E2 elimination through classic S
Because of the three-dimensional bioisosteric feature, bicyclo[1.1.1]pentylamines (BCPAs) are valuable scaffolds in synthetic chemistry and medicinal chemistry. Here, we report a Halogen Atom Transfer (XAT) mediated radical C-N coupling between C3-iodo-BCPs diazonium salts presence base. Similarly, multicomponent reaction (MCR) enables simultaneous construction C-C bond simultaneously. Versatile roles were also explored.
LoRA (Low-Rank Adaptation) is a widely used model fine-tuning method. In fine-tuning, the law among performance, parameters, and data complexity has been focal issue in field. Existing methods often leverage external metrics (such as cross-entropy or perplexity) to evaluate performance. process for large models, two types of knowledge are typically involved: frozen, general acquired by during pre-training new learned through module from current data. Generally, less LoRA's relies on model,...
The luteinizing hormone-releasing hormone-Pseudomonas aeruginosa exotoxin 40 (LHRH-PE40), is a candidate target drug associated with elevated LHRH receptor (LHRH-R) expression in malignant tumor tissue. capability of LHRH-PE40 to recognize LHRH-Rs on living cell membrane was studied single molecular recognition force spectroscopy (SMFS) based atomic microscopy (AFM). LHRH-PE40/LHRH-R compared that LHRH/LHRH-R by dynamic spectroscopy. Meanwhile, growth inhibition assay and fluorescence...
An efficient methodology to access various fluoroalkyl sulfoxides bearing ortho/para-functionalized amine scaffolds from arylhydroxylamines is described. The transformation was featured with new electrophilic trifluoromethylthiolated reagents, good functional group tolerance, and late-stage modification of complex bioactive scaffolds, providing a rapid prepare numerous trifluoromethyl- difluoromethyl-substituted sulfoxides. Mechanism studies density theory calculations suggest this reaction...
Objectives Since 2009, China has introduced policies, principally targeting health professionals, to reduce caesarean section (CS) overuse. In 2016, endorsed a universal two-child policy. Advanced maternal age and previous CS may indicate changes in obstetric risks, which raise concerns on the need for safety of CS. This study investigated rates 2008–2018, factors associated with use during period transition from one-child policy era. Design We used births data cross-sectional National...
Accumulating evidence suggests that extracellular alpha-synuclein (eSNCA) plays an important role in the pathogenesis of Parkinson's disease or related synucleinopathies by inducing neurotoxicity directly indirectly via microglial astroglial activation. However, mechanisms which this occurs remain to be characterized. To explore these mechanisms, we combined three biochemical techniques - stable isotope labeling amino acid cell cultures (SILAC), biotin plasma membrane proteins followed...
To avoid random chemical linkage and achieve precisely directed immobilization, mutant enzymes were obtained immobilized using an incorporated reactive nonstandard amino acid (NSAA). For this purpose, aldehyde ketone reductase (AKR) was used as a model enzyme, 110Y, 114Y, 143Y, 162Q 189Q each replaced with p-azido-l-phenylalanine (pAzF). Then, the AKR coupled to functionalized support by strain-promoted alkyne-azide cycloaddition (SPAAC). The effects of incorporation number site NSAAs on...
Genetically encoded nonstandard amino acids (NSAAs) facilitate the covalent assembly of enzymes and enable their self-purification, enhanced activity stability.
Engineering of biological pathways with man-made materials provides inspiring blueprints for sustainable drug production. (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol [(R)-3,5-BTPE], as an important artificial chiral intermediate complicated pharmaceutical drugs and biologically active molecules, is often synthesized through a hydrogenation reaction 3,5-bis(trifluoromethyl)acetophenone (3,5-BTAP), in which enantioselectivity sufficient hydrogen are the key to restricting reaction. In this...
To develop health literacy assessment instrument for patients with chronic pain.Qualitative methods based on Delphi technique, assessed against the CREDES checklist.A 2-round method was adopted in this study. The panel consisted of 19 experts.The pain constructed, which contained 3 dimensions (functional literacy, interactive and critical literacy) 41 items. positive coefficients two rounds were 100.00% 89.5%, respectively. authority coefficient experts 0.848 0.858, coordination dimension...
To improve the proteolytic stability of lipase LIP2 from Yarrowia lipolytica, peptide bonds susceptible to trypsin in were analyzed by tandem mass spectrometry and redesigned site-directed mutagenesis. Different variants enzyme expressed Pichia pastoris GS115 their biochemical properties subsequently investigated. Although most still cleaved trypsin, some them did show an evident increase resistance against degradation. The stable mutant was LIP2-C5, which five trypsin-cleavage sites...