A5081493881- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Traditional Chinese Medicine Studies
- Flavonoids in Medical Research
- Menstrual Health and Disorders
- Plant-based Medicinal Research
- Advancements in Transdermal Drug Delivery
- Phytochemistry and Bioactive Compounds
- Biochemical Analysis and Sensing Techniques
- Berberine and alkaloids research
- Essential Oils and Antimicrobial Activity
- Dermatology and Skin Diseases
- Bee Products Chemical Analysis
- Phytochemicals and Antioxidant Activities
- Ginkgo biloba and Cashew Applications
- Toxin Mechanisms and Immunotoxins
- Gut microbiota and health
- Phytochemical Studies and Bioactivities
- Advances in Cucurbitaceae Research
- Ginger and Zingiberaceae research
Nanjing University of Chinese Medicine
2015-2024
Zero to Three
2020
Sichuan Academy of Agricultural Sciences
2018
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2017
Affiliated Hospital of Chengde Medical College
2017
Shanghai Innovative Research Center of Traditional Chinese Medicine
2015
Chengde Medical University
2015
Wuhan University of Technology
2014
657 Oslo
2014
Zhejiang Chinese Medical University
2011
Methotrexate (MTX) is one of the first-line treatments for moderate to severe psoriasis, while side effects caused by injection and oral administration MTX greatly restrict its clinical application. Transdermal drug delivery offers a desirable alternative conventional approaches, but performances currently available skin penetration enhancement techniques are not so satisfactory. To address these limitations, we developed dissolving microneedle (MN) patch made hyaluronic acid (HA) with...
The present study was conducted to evaluate and compare five essential oils (EOs) as penetration enhancers (PEs) improve the transdermal drug delivery (TDD) of ibuprofen treat dysmenorrhoea. EOs were prepared using steam distillation method their chemical compositions identified by GC-MS. corresponding cytotoxicities evaluated in epidermal keartinocyte HaCaT cell lines an MTT assay. Furthermore, percutaneous permeation studies carried out enhancement effect EOs. Then therapeutic efficacy...
Primary dysmenorrhea is one of the most common gynecological complaints in young women, but potential peripheral immunologic features underlying this condition remain undefined. In paper, we compared 84 cytokine gene expression profiles blood mononuclear cells (PBMCs) from six primary dysmenorrheic women and three unaffected controls on seventh day before (secretory phase), first (menstrual phase) fifth (regenerative days menstruation, using a real-time PCR array assay combined with pattern...
Essential oils (EOs) have shown the potential to reversibly overcome stratum corneum (SC) barrier enhance skin permeation of drugs.The effectiveness turpentine, Angelica, chuanxiong, Cyperus, cinnamon, and clove were investigated for capacity mechanism promote penetration ibuprofen.Skin studies ibuprofen across rat abdominal with presence 3% w/v EOs carried out; samples withdrawn from receptor compartment at 8, 10, 22, 24, 26, 28, 32, 36, 48 h analyzed content by HPLC method. The mechanisms...
Primary dysmenorrhea (PDM), a common clinical endocrine disorder affecting young women, is associated with endocrinopathy and metabolic abnormalities. Although some physiological pathological function parameters have been investigated, little information about the changes of small metabolites in biofluids has reported, which may cause poor diagnosis treatment for PDM. The Xiang-Fu-Si-Wu Formula (XFSWF) Chinese herbal formula used to treat PDM hundreds years. aim this study was establish...
Abstract Frankincense and myrrh are highly effective in treatment of inflammatory diseases, but lacking the therapy mechanisms. We undertook this study to evaluate effects on Adjuvant-induced Arthritis (AIA) rats explore underlying mechanisms by analyzing metabolic profiling signaling pathway evaluated expression cytokines, c-jun c-fos corresponding phosphorylation levels. The results stated elevated levels TNFα, PGE 2 , IL-2, NO MDA serum swelling paw AIA were significantly decreased after...
Introduction Dendrobium officinale is an endangered perennial epiphytic herbaceous plant. In the Chinese Pharmacopoeia, dried stems of D. are used medicinally and commonly utilized as a medicinal food homologous product. Notable variations in quality observed across different cultivation environments; however, underlying mechanisms remain unclear. Methods Metabolites grown stone epiphytic, tree greenhouse environments were identified using UPLC-MS/MS-based widely targeted metabolomics....
Ginkgo ketoester tablets (GT) and donepezil were a clinically used combination for the treatment of Alzheimer’s disease (AD). The aim study was undertaken to investigate antiamnesic effects two drugs alone in through vivo models Morris water maze along with vitro antioxidants, acetylcholinesterase (AChE) butyrylcholinesterase (BuChE). potential mechanisms speculated by activities acetylcholine (ACh), AChE, superoxide dismutase (SOD), malondialdehyde (MDA) protein expression brain-derived...
Kai-xin-san (KXS) is a famous Chinese medicinal formula applied for treating stress-related psychiatric diseases with the symptoms such as depression, forgetfulness and dizziness. In clinic, composition ratio of KXS always varied series formulae are created. Here, we aim to compare anti-depressive effect different ratios reveal its action mechanism on regulation neurotrophic factor system. Firstly, daily intra-gastric administration chemically standardized extracts seven days significantly...
Primary dysmenorrhea (PD) is characterized by painful menstrual cramps without any organic pathology and has a prevalence of up to 90% in adolescents. Recent advances its etiology pathogenesis are providing more speculative hypotheses focused on integral systems. Using targeted tandem mass spectrometry (MS/MS)-based metabolomic platform, we explored the changes metabolic profiling plasma/urine simultaneously between PD patients healthy controls before after 3-month herbal medicine (namely...
Abstract The management of critical‐sized bone defects presents a formidable clinical challenge, especially given the increasing incidence diseases in aging population. Consequently, there is an increased demand for minimally invasive repair materials that can effectively address this particularly outpatient settings. In study, goal to develop injectable and biodegradable biomaterial adheres fills bone‐defect sites support regeneration. osteogenic angiogenic activities animal horn peptides...
Objective: To investigate the metabolic routes and metabolites of myricitrin, an important active ingredient traditional herbal medicine, yielded by isolated human intestinal bacteria, which have not been reported previously.Methods: Fresh fecal samples were collected from a healthy female volunteer about 100 different bacterial colonies isolated. Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry technique combined with Metabolynx™ software was used for...