A5014520634- Liver physiology and pathology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Wound Healing and Treatments
- Cellular transport and secretion
- Tissue Engineering and Regenerative Medicine
- Mosquito-borne diseases and control
- Pancreatic function and diabetes
- Zoonotic diseases and public health
- Bacterial Identification and Susceptibility Testing
- Dermatologic Treatments and Research
- Antimicrobial Resistance in Staphylococcus
- Organ and Tissue Transplantation Research
- Microbial infections and disease research
- Silk-based biomaterials and applications
- Nail Diseases and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Developmental Biology and Gene Regulation
- Fibroblast Growth Factor Research
- Antibiotic Resistance in Bacteria
- Neurofibromatosis and Schwannoma Cases
- Burn Injury Management and Outcomes
- Periodontal Regeneration and Treatments
- Wnt/β-catenin signaling in development and cancer
- Animal Disease Management and Epidemiology
University of Turin
2010-2024
Ospedali Riuniti di Ancona
2023
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2015
Candiolo Cancer Institute
1997-2011
CTO Hospital
1994-2009
University Medical Center Utrecht
2000
Sapienza University of Rome
2000
Max Planck Institute for Developmental Biology
1994-1996
Met, the high affinity receptor for hepatocyte growth factor, is one of most frequently activated tyrosine kinases in human cancer and a validated target therapy. We previously developed mouse monoclonal antibody directed against extracellular portion Met (DN-30) that induces proteolytic cleavage (receptor "shedding") followed by proteasome-mediated degradation. This translates into inhibition factor/Met-mediated biological activities. However, DN-30 binding to also results partial...
Matriptase, also known as membrane-type-serine-protease 1 (MT-SP 1), is a type II transmembrane serine protease involved in the activation of precursor form hepatocyte growth factor/scatter factor (pro-HGF/SF). Since HGF/SF well-known extracellular signal, which plays key role control invasive growth, we investigated effects matriptase inhibition cell lines derived from colon (DLD-1) or prostate (PC-3) carcinomas. Biochemical analysis showed that was very efficient proteolytic conversion...
In livestock, the importance of hygiene management is gaining within context biosecurity. The aim this study was to monitor implementation biosecurity and procedures in 20 swine herds over a 12-month period, as driven by tailor-made plans, including training on-farm. measure adenosine triphosphate (ATP) environmental contents used an output biomarker. presence livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) extended-spectrum β-lactamase producing Escherichia coli...
The Slit protein acts through the Roundabout receptor as a paracrine chemorepellent in axon guidance and an inhibitor leukocyte chemotaxis, but its role epithelial cell motility morphogenesis remains largely unexplored. We report that nontransformed cells cancerous empower Slit-2/Robo1 signaling system to limit outward migration response motogenic attractants remain positionally confined within their primitive location. Short hairpin RNA-mediated depletion of SLIT-2 or ectopic expression...
The hepatocyte growth factor (HGF) receptor encoded by the Met oncogene controls a genetic program—known as "invasive growth"—responsible for several developmental processes and involved in cancer invasion metastasis. This program functions through regulatory gene products, yet largely unknown, both upstream downstream of Met. Here we show that activation Notch results transcriptional down-regulation Met, suppression HGF-dependent Ras signaling, impairment cellular responses. In turn, leads...
Swine farming as a source of methicillin-resistant Staphylococcus aureus (MRSA) has been well documented. Methicillin-resistant coagulase-negative staphylococci (MRCoNS) have less studied, but their importance pathogens is increasing. MRCoNS are indeed considered relevant nosocomial pathogens; identifying putative sources thus gaining to prevent human health hazards. In the present study, we investigated MRSA and in animals environment five pigsties high farm-density area northwestern Italy....
ABSTRACT We have analysed the developmental defects in Drosophila embryos lacking a gelsolin-related protein encoded by gene flightless I. Such previously been reported to gastrulate abnormally. now show that most dramatic are seen earlier, actin-dependent events during cellularisation of syncytial blastoderm, process with similarities cytokinesis. The blastoderm nuclei migrate periphery egg normally but lose their precise cortical positioning cellularisation. Cleavage membranes initially...
The authors investigated immunocytochemically the innervation of a skin biopsy in rare case hereditary sensory and autonomic neuropathy type IV. A few protein gene product 9.5-, growth-associated 43-, calcitonin gene-related peptide-, substance P-immunoreactive nerve fibers were observed deeper regions dermis. Neuropeptide Y-, nitric oxide-, vasoactive intestinal polypeptide-immunoreactive completely absent. Their observations support hypothesis that defects reported are based on profound...
This study is the first report on genetic and pathogenic characterization of beak feather disease virus (BFDV) occurring in Italy. Twenty BFDV strains isolated Italy from juvenile Congo African grey parrots (Psittacus erithacus) were investigated. Seventeen showed an "atypical peracute form" (aPF) disease, three a chronic form (CF). The birds with aPF had been weaned, independent as far food protection concerned apparently without lesions. gene coding for putative coat protein was amplified...
We have cloned the gene for Drosophila gelsolin. Two mRNAs are produced from this by differential splicing. The protein encoded longer mRNA has a signal peptide and its electrophoretic mobility when translated in vitro presence of microsomes is higher than it without microsomes. shorter does not show difference. This indicates that like vertebrates two forms gelsolin, one secreted, other cytoplasmic. both present ubiquitously early embryo. Later, cytoplasmic form expressed parts gut. RNA...
Macrophage stimulating protein (MSP), also known as hepatocyte growth factor-like, is a soluble cytokine that belongs to the family of plasminogen-related factors (PRGFs). PRGFs are α/β heterodimers bind transmembrane tyrosine kinase receptors. MSP was originally isolated chemotactic factor for peritoneal macrophages. Through binding its receptor, encoded by RON gene, it stimulates dissociation epithelia and works an inflammatory mediator repressing production nitric oxide (NO). Here, we...
Identified the role of hatchery in astrovirus transmission.Sequenced avian nephritis virus complete genome.Investigated tissue distribution from egg to chicks.Demonstrated co-infection ANV/CAstV.