A5053245885- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Botulinum Toxin and Related Neurological Disorders
- Medical and Biological Ozone Research
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
Theodor Bilharz Research Institute
2023
University of Bern
2019-2021
Aswan University
2021
Beta toxin (CPB) is a small hemolysin beta pore-forming (β-PFT) produced by Clostridium perfringens type C. It plays central role in the pathogenesis of necro-hemorrhagic enteritis young animals and humans via targeting intestinal endothelial cells. We recently identified membrane protein CD31 (PECAM-1) as receptor for CPB on mouse now assess cytotoxicity against human monocytic cells using CRISPR/Cas9 gene knockout an antibody blocking approach. were resistant to oligomers only formed...
Background: There has been a significant rise in morbidity and mortality due to infections caused by Candida spp. with an upsurge the incidence of non-albicans (NAC), where clinical outcome is affected their decreased susceptibility azoles.Accurate identification important step that leads selecting suitable antifungal agent.Objectives: This study aimed identify main NAC hospital setting determine susceptibility.Methodology: 133 isolates were identified culture on Sabouraud Dextrose Agar,...
SUMMARY Clostridium perfringens β-toxin (CPB) is a highly active hemolysin β-pore forming toxin and the essential virulence factor for severe, necro-hemorrhagic enteritis in animals humans. In vivo vitro it exerts remarkable cell type specificity towards endothelial cells, platelets some leucocytic lines. The target of CPB is, however, poorly understood receptor explaining this selective toxicity has not been identified. This hampered further research into pathogenesis C. C induced...