A5100891376- Influenza Virus Research Studies
- Respiratory viral infections research
- Virology and Viral Diseases
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Technology Adoption and User Behaviour
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
First Affiliated Hospital of Guangzhou Medical University
2013-2014
State Key Laboratory of Respiratory Disease
2014
Guangzhou Medical University
2013-2014
Preventing and treating influenza virus infection remain a challenge because of incomplete understanding the host–pathogen interactions, limited therapeutics lack universal vaccine. So far, methods for monitoring course with in real time living animals are lacking. Here we report visualization viral mice using an engineered replication-competent A carrying luciferase reporter gene. After intranasal inoculation, bioluminescence can be detected chest nasopharyngeal passage mice. The intensity...
Forty-two H9N2 subtype AIV strains were isolated from vaccinated commercial chickens in China 2012 to 2015. Their HA genes had nucleotide sequence homology 86.7% 99.7%, and similarity the classic vaccine strain was 88.6%–92.6%. A comparison carried out with published (410 H9 strains) whole genomes (306 during 2012–2015. Interestingly, 99.1% (448/452) of Chinese belonged lineage h9.4.2, 98.5% (445/452) viruses h9.4.2.5. Meanwhile, 99.6% (443/445) 9.4.2.5 PSRSSR↓GLF instead PARSSR↓GLF motifs...
Background The outbreaks of emerging infectious diseases caused by pathogens such as SARS coronavirus, H5N1, H1N1, and recently H7N9 influenza viruses, have been associated with significant mortality morbidity in humans. Neutralizing antibodies from individuals who recovered an infection confer therapeutic protection to others infected the same pathogen. However, survivors may not always be available for providing plasma or cloning monoclonal (mAbs). Methodology/Principal Findings genome...