A5101957070- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Medicinal Plant Pharmacodynamics Research
- RNA modifications and cancer
- Bioactive Compounds and Antitumor Agents
- Flavonoids in Medical Research
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Natural product bioactivities and synthesis
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
Shandong University of Traditional Chinese Medicine
2018-2023
Ocean University of China
2007
Deep Candida albicans infection is one of the major causes death in immunosuppressed hosts. Remodeling macrophages to phenotype M1 can decrease fungus burden and facilitate combating C. under an immunosuppressive state. In this study, a nanotrinity was exploited direct fungicidal macrophage polarization by leveraging regulation pathways redifferentiation. Conventional chemotherapeutic imatinib, which abrogate M2 via "shutting off" STAT6 phosphorylation pathway, encapsulated biodegradable...
Immune checkpoint blockade (ICB) has emerged as one of the breakthrough approaches for tumor immunotherapy. However, known an immune "cold" tumor, breast cancer harbors immunosuppressive niche that compromises ICB-based therapy. Chemoimmunotherapy combines a chemotherapeutic with immune-modulating agent, representing promising tactic to combat cancers, while lack effectively targeted co-delivery strategy is main obstacles achieve synergistic utilization. Herein, self-assembled PEGylated pure...
As one of the many breast cancer subtypes, human epidermal growth factor receptor 2 (Her2)-positive has higher invasiveness and poor prognosis, although advent anti-Her2 drugs brought good news to patients. However, emergence drug resistance still limits its clinical efficacy, so there is an urgent need explore new targets develop a risk scoring system improve treatments evaluate patient prognosis.Differentially expressed mRNAs associated with Her2-positive were screened from TCGA cohort....
Zhenlong Xingnao Capsule (ZXC) is a Tibetan medicine used to treat ischemic stroke. In this study, we determined the in vitro and vivo effects of ZXC on reactive oxygen species (ROS) mouse BV-2 microglial cell hypoxia-reoxygenation rat middle cerebral artery occlusion infarction models. We aimed clarify role ischemia protection; reveal amino acid neurotransmitter changes frontal cortex after drug intervention; determine mRNA protein expression Bcl-2, Bax, caspase-3, P38, nuclear factor...
Epithelial-mesenchymal transition (EMT) is a biological process involved in tumor migration, invasion, and radiotherapy resistance. Bufalin can affect the proliferation, apoptosis invasion of cells by regulating multiple signaling pathways. Whether bufalin increase radiosensitivity through EMT deserves further investigation.In this study, we investigated effect on non-small cell lung cancer (NSCLC) underlying molecular mechanism. NSCLC were treated with (at dose 0-100 nM) or irradiated 6 MV...
Lung squamous cell carcinoma (LUSC) is characterized by poor prognosis and obvious limitations of therapeutic methods. The molecular target mechanism quercetin (QR), a natural anticancer product with extensive pharmacological activities, on lung still unclear.The effects QR LUSC were examined using proliferation, migration, invasion tests. Key genes screened Cancer Genome Atlas (TCGA) database, Gene Ontology (GO)/Kyoto Encyclopedia Genes Genomes (KEGG) STRING website, topology, analysis,...
The high heterogeneity of breast cancer (BRCA) makes it more challenging to interpret the genetic variation mechanisms involved in BRCA pathogenesis and prognosis. Areas with DNA methylation (such as CpG islands) were accompanied by copy number (CNV), these genomic variations affected level methylation. In this study, we characterized intertumor analyzed effects CNV on gene expression. addition, performed a Genetic Set Enrichment Analysis (GSEA) identify key pathways for changes between...
Neuroinflammation plays an important role in the pathogenesis of neurological disorders, and despite intensive research, treatment neuroinflammation remains limited. BaiXiangDan capsule (BXD) is widely used clinical practice. However, systematic studies on direct mechanisms BXD are still lacking. We systematically evaluated potential pharmacological using network analysis combined with experimental validation. Multiple databases to mine targets for bioactive ingredients, drug...
The effect of pyroptosis-related genes (PRGs) on the tumor microenvironment (TME) in lung adenocarcinoma (LUAD) remains unclear. Thus, this study is aimed at evaluating prognostic value PRGs patients with LUAD and to elucidate their role TME immunotherapy. Transcriptomic clinical data were obtained from Cancer Genome Atlas Gene Expression Omnibus databases (GSE3141, GSE31210). Patients classified using consistent clustering, differences for each type determined ESTIMATE CIBERSORT algorithms....