A5102905055- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Colorectal Cancer Treatments and Studies
- Bioinformatics and Genomic Networks
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Immune cells in cancer
- 14-3-3 protein interactions
- Groundwater and Watershed Analysis
- Toxin Mechanisms and Immunotoxins
- Gene expression and cancer classification
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Myeloid Leukemia Treatments
- Ginseng Biological Effects and Applications
- Lung Cancer Research Studies
Weifang Medical University
2022-2025
Second Hospital of Shandong University
2024
Jilin University
2022-2023
Xuzhou Medical College
2023
Shandong University of Traditional Chinese Medicine
2018-2022
Weifang Chinese Medicine Hospital
2020
Growing evidence has shown that a large number of miRNAs are abnormally expressed in cervical cancer (CC) tissues and play irreplaceable roles tumorigenesis, progression, metastasis. This study aimed to identify new biomarkers pivotal genes associated with CC prognosis through comprehensive bioinformatics analysis. At first, the data gene expression microarray (GSE30656) was downloaded from GEO database differential were obtained. Additionally, 4 survival time patients screened TCGA...
Studies have shown that long noncoding RNAs (lncRNAs) make up the major proportion of ceRNA network and can regulate gene expression by competitively binding to miRNAs. This reveals existence an RNA-miRNA regulatory pathway is great biological significance. CeRNAs, as competitive endogenous RNAs, revealed a new mechanism interaction between RNAs. Until now, role lncRNA-mediated ceRNAs in breast cancer their mechanisms been elucidated some extent.In this study, comprehensive analysis...
Abstract Advances in cancer biology have allowed early diagnosis and more comprehensive treatment of breast (BC). However, it remains the most common cause death women worldwide because its strong invasiveness metastasis. In‐depth study molecular pathogenesis BC relevant prognostic markers would improve quality life prognosis patients. In this study, bioinformatics analysis SNP‐related data from patients provided TCGA database revealed that six mutant genes ( NCOR1, GATA3, CDH1, ATM, AKT1,...
In recent years, the emergence of immunotherapy has provided a new perspective for treatment and management triple-negative breast cancer (TNBC). However, relationship between tumor mutation burden (TMB) immune infiltration prognosis TNBC remains unclear. this study, to explore immunogenicity TNBC, we divided patients with into high low TMB groups based on somatic data in The Cancer Genome Atlas (TCGA), screened out genes rate ≥10. Then, Kaplan-Meier survival analysis revealed that 5-year...
The elevation of TyG is considered an important factor in promoting the progression non-alcoholic fatty liver disease (NAFLD), but its impact on degree steatosis remains unclear. This study aims to explore relationship between and TyG-related indices, such as triglyceride glucose-body mass index (TyG-BMI), with fat accumulation.From January 2021 March 2022, 1171 participants underwent health check-ups, all FibroScan transient elastography. analysis focused identifying factors that contribute...
Background: Breast cancer is one of the deadliest malignant tumors worldwide. Due to its complex molecular and cellular heterogeneity, efficacy existing breast risk prediction models unsatisfactory. In this study, we developed a new lncRNA model predict prognosis patients with BRCA. Methods: BRCA-related differentially-expressed long non-coding RNA were screened from Cancer Genome Atlas database. A novel was by univariate multivariate analyses The verified TCGA-based samples. Identified...
Background: Studies have shown that the natural products of Astragalus membranaceus (AM) can effectively interfere with a variety cancers, but their mechanism action on breast cancer remains unclear. Triple-negative (TNBC) is associated severely poor prognosis due to its invasive phenotype and lack biomarker-driven-targeted therapies. In this study, potential target composition acting TNBC was explored by integrated pharmacological models in vitro experiments. Materials Methods: Based Gene...
Background: Astragalus polysaccharides (APS), natural plant compounds, have recently emerged as a promising strategy for cancer treatment, but little is known concerning their effects on breast (BC) tumourigenesis. Methods: We obtained genetic data from The Cancer Genome Atlas (TCGA) database, network pharmacology to further clarify its biological properties. Survival analysis and molecular docking techniques were implemented the final screening obtain key target information. Our experiments...
Triple-negative breast cancer (TNBC) is an aggressive metastatic subtype of BC that frequently develops chemoresistance. Immune checkpoint blockers (ICB) have led to breakthroughs in TNBC treatment. This study aimed explore research trends and public interest ICB interventions for TNBC. We searched the Web Science Core Collection (WoSCC) database publications related from 2003 2024. VOSviewer, CiteSpace, R package "bibliometrix" were used analyze characteristics a quantitative qualitative...
As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to adenocarcinoma (LUAD) provide basis for prognosis prediction personalized targeted therapy LUAD patients.The methylation survival time data from patients TCGA database were downloaded. The MethylMix algorithm was used identify differential status adjacent tissues based on β-mixture model obtain...
Abstract Recently, increasing evidences show that circular RNAs (circRNAs) are important regulators of various diseases, especially cancer. However, the regulatory role and potential mechanism action circRNAs in breast cancer remain largely unknown. In this study, weighted gene co‐expression network analysis was conducted with differentially expressed miRNAs mRNAs from The Cancer Genome Atlas database to identify key modules associated carcinogenesis significant turquoise brown modules, 22...
The risk of brain metastasis (BM) in HER2-positive (+) breast cancer (BC) patients is significantly higher than that HER2-negative (-) BC patients. high incidence and mortality rate makes it urgent to elucidate the key pathways genes involved identify who are more at developing BM.To target HER2+BC with BM, we analyzed microarray datasets (GSE43837) derived from Gene Expression Omnibus (GEO) database. GEO2R tool was used extract differentially expressed (DEGs) HER2+ primary BM....
Abstract Previous studies on long noncoding RNA (lncRNA) have made breakthroughs in the treatment of several tumors, and these findings brought attention to lncRNA signature breast cancer. Increased understanding genomic architecture achievement innovative therapeutic strategies has prompted creation a novel oncological model for solid cancers. In this study, we systematically analyzed transcriptome cancer tissues gain more in‐depth knowledge tumor biology. Gene coexpression relationships...