A5101277580- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Bone Tumor Diagnosis and Treatments
- Genetic Associations and Epidemiology
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Bioactive Compounds and Antitumor Agents
- Advances in Cucurbitaceae Research
- Lipoproteins and Cardiovascular Health
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
Shandong University of Traditional Chinese Medicine
2023-2025
Weifang Chinese Medicine Hospital
2024-2025
Air Force Medical University
2023
Weifang Medical University
2020
Triple-negative breast cancer (TNBC) is an aggressive metastatic subtype of BC that frequently develops chemoresistance. Immune checkpoint blockers (ICB) have led to breakthroughs in TNBC treatment. This study aimed explore research trends and public interest ICB interventions for TNBC. We searched the Web Science Core Collection (WoSCC) database publications related from 2003 2024. VOSviewer, CiteSpace, R package "bibliometrix" were used analyze characteristics a quantitative qualitative...
Although several preclinical and epidemiological studies have shown that blood lipids lipid-lowering drugs can reduce the risk of breast cancer, this finding remains controversial. This study aimed to explore causal relationship between dyslipidemia,lipid-lowering drugs, cancer. We also evaluate potential impact drug targets on Data 431 lipid- lipid-related phenotypes were obtained from genome-wide association (GWAS), mendelian randomization (MR) analyses performed using two independent...
Abstract Background Dysregulation of cholesterol metabolism is a significant characteristic glioma, yet the underlying mechanisms are largely unknown. N6-methyladenosine (m6A) modification has been implicated in promoting tumor development and progression. The aim this study was to determine key m6A regulatory proteins involved progression which potentially associated with reprogramming homeostasis. Methods Bioinformatics analysis performed association glioma malignancy from Cancer Genome...
Triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype of cancer, lacks effective treatment options. Sophora flavescens Aiton, Chinese medicinal plant, is often used in traditional medicine to treat cancer. Matrine (MAT) an alkaloid extracted from flavescens. It has good anticancer effects, thus can be explored as new therapeutic agent TNBC research. We performed bioinformatics analysis analyze the differentially expressed genes between normal tissues tissues,...
<title>Abstract</title> Previous studies have suggested a potential association between fibroblast growth factors and breast cancer, but the evidence for relationship specific with cancer is limited controversial. To explore interactions 13 (FGFs) 3 factor receptors (FGFRs) we conducted mendelian randomization study based on GWAS summary statistics of European ancestry. The IVW analysis showed that overall FGF20 genetically protective effect, FGF4 can promote risk cancer. FGF1 FGF7 were...
Purpose This study aimed to construct a prediction model regarding risk factors and prognostic for distant metastasis of T1-T3 stage rectal cancer. For this purpose, population-based retrospective cohort was conducted. Methods Data on 7872 patients diagnosed with cancer between 2004 2020 were obtained from the Surveillance, Epidemiology, End Results database, whom 746 had metastases at diagnosis. Independent determined using univariate multivariate logistic regression analyses. Cox...
Abstract Background: The intrinsic molecular subtypes of lung adenocarcinoma (LUAD) impact clinical treatment decision-making, but the mechanisms are still unclear. Therefore, we aimed to identify sensitive biomarkers evaluate LUAD patient prognosis. Methods: Differentially expressed RNAs from patients were obtained Cancer Genome Atlas (TCGA) database and they used construct a competitive endogenous RNA (ceRNA) network. Based on examination data, long noncoding (lncRNAs) mRNAs in network...