A5087555672- Nitric Oxide and Endothelin Effects
- Spaceflight effects on biology
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- S100 Proteins and Annexins
- Advanced battery technologies research
- Advanced Battery Technologies Research
- Coenzyme Q10 studies and effects
- Pancreatic function and diabetes
- Cardiomyopathy and Myosin Studies
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Animal Genetics and Reproduction
- Space Exploration and Technology
- Fluid Dynamics and Turbulent Flows
- Cardiac Fibrosis and Remodeling
- Heat Transfer Mechanisms
- Pharmacogenetics and Drug Metabolism
- Vitamin K Research Studies
- Computational Fluid Dynamics and Aerodynamics
- Electromagnetic Fields and Biological Effects
- Law in Society and Culture
- Infectious Encephalopathies and Encephalitis
- Aerodynamics and Acoustics in Jet Flows
Eastern Health
2023
Alfred Health
2020
Baker Heart and Diabetes Institute
2009-2015
Guy's and St Thomas' NHS Foundation Trust
2015
Murdoch Children's Research Institute
2012
The University of Melbourne
2012
Monash University
2010
Johnson Space Center
2004-2009
Furman University
2008
Wyle (United States)
2001
St John's wort (SJW), an extract of the medicinal plant Hypericum perforatum, is widely used as a herbal antidepressant. Recently, this agent has been found to adversely affect metabolism various coadministered drugs. Steroid X receptor (SXR), orphan nuclear receptor, induces hepatic cytochrome P450 gene expression in response diverse endogenous steroids, xenobiotics and Here, we report that, when coexpressed with SXR, reporter construct derived from 3A promoter activated by wort. A GAL4-SXR...
OBJECTIVE Compelling epidemiological and clinical evidence has identified a specific cardiomyopathy in diabetes, characterized by early diastolic dysfunction adverse structural remodeling. Activation of the insulin-like growth factor 1 (IGF-1) receptor (IGF-1R) promotes physiological cardiac enhances contractile function. The aim present study was to examine whether cardiac-specific overexpression IGF-1R prevents diabetes-induced myocardial remodeling associated with murine model diabetes....
Annexin-A1 (ANX-A1) is an endogenous, glucocorticoid-regulated anti-inflammatory protein. The N-terminal-derived peptide Ac-ANX-A1(2-26) preserves cardiomyocyte viability, but the impact of ANX-A1-peptides on cardiac contractility unknown. We now test hypothesis that ANX-A1 post-ischaemic recovery left ventricular (LV) function.Ac-ANX-A1(2-26) was administered reperfusion, to adult rat cardiomyocytes as well hearts isolated from rats, wild-type mice and deficient in endogenous (ANX-A1(-/-))....
Background Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences soluble guanylyl cyclase (sGC) activator BAY 58-2667 on remodeling, independent changes in hemodynamic load, has not been investigated. In present study, we tested hypothesis that NO•-independent sGC inhibits cardiomyocyte hypertrophy vitro. Concomitant impact fibroblast proliferation, and insights into potential mechanisms action, were also sought. Results compared to...
Background New therapeutic targets for cardiac hypertrophy, an independent risk factor heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention the treatment cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent positive inotropy. The impact on hypertrophy (which negatively regulated by cGMP) however has not been investigated. Methods Neonatal rat cardiomyocytes were incubated with angiotensin II (Ang II)...
Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) are an emerging threat in both solid organ and stem cell transplant recipients. Invasive CPE infections recipients associated with a high mortality, often due to limited therapeutic options antibacterial toxicities. One of the most therapeutically challenging group metallo-β-lactamase (MBL)-producing Gram-negative bacteria, which now found worldwide, need treatment older, highly toxic antimicrobial regimens. Newer...
Nitroxyl (HNO) is a redox congener of NO. We now directly compare the antihypertrophic efficacy HNO and NO donors in neonatal rat cardiomyocytes their contributing mechanisms actions this setting. Isopropylamine-NONOate (IPA-NO) elicited concentration-dependent inhibition endothelin-1 (ET1)-induced increases cardiomyocyte size, with similar suppression hypertrophic genes. Antihypertrophic IPA-NO were significantly attenuated by l-cysteine (HNO scavenger), Rp-8-pCTP-cGMPS (cGMP-dependent...
Objective Emerging evidence suggests female type 2 diabetes (T2DM) patients may fare worse than males with respect to cardiovascular complications. Hence the impact of sex on relative progression left ventricular (LV) remodeling in obese db/db mice was characterized. Methods The changes parameters LV hypertrophy (heart weight, pro‐hypertrophic gene expression, cardiomyocyte size) and fibrosis (LV collagen deposition oxidative stress), parallel body weight blood glucose lipid profiles, male...
Global migration has led to female genital mutilation/cutting (FGM/C) being seen in many parts of the world, including UK. The aim this article is provide insight into perceptions FGM/C migrant communities inform culturally relevant approaches by specialist community public health nurses working with practising families. A review 10 pieces primary research found that women migrating a European country and coming contact services had major shift their attitudes towards FGM/C, from acceptance...
Results IPA-NO elicited concentration-dependent inhibition of endothelin-1 (ET1)-induced increases in neonatal rat cardiomyocyte size, with similar suppression hypertrophic genes. Antihypertrophic actions were significantly attenuated by L-cysteine (HNO scavenger), Rp-8-pCTPcGMPS (cGMP-dependent protein kinase inhibitor), and ODQ (to target soluble guanylyl cyclase, sGC), but unaffected carboxy-PTIO (NO• scavenger) or CGRP837 (calcitonin gene-related peptide antagonist). Furthermore,...
The glucocorticoid-regulated protein annexin-A1 (ANX-A1) is a key effector molecule of anti-inflammatory glucocorticoid actions. We have shown that the N-terminal derived peptide ANX-A1(2–26) preserves cardiomyocyte viability after metabolic inhibition in vitro. Our hypothesis was ANX-A1 myocardium post-ischemic injury. ANX-A1(2–26)(0.3μM) prevented adult rat injury, whether present for hypoxia-reoxygenation (LDH release reduced from 4.1±0.7- to 1.1±0.2-fold n=11 P<0.001) or only on...