A5067441485- Anatomy and Medical Technology
- Surgical Simulation and Training
- Reconstructive Surgery and Microvascular Techniques
- Nitric Oxide and Endothelin Effects
- Facial Trauma and Fracture Management
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Esophageal and GI Pathology
- Dental Radiography and Imaging
- S100 Proteins and Annexins
- Bone fractures and treatments
- Cardiac electrophysiology and arrhythmias
- Aortic aneurysm repair treatments
- Facial Nerve Paralysis Treatment and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hormonal Regulation and Hypertension
- Artificial Intelligence in Healthcare and Education
- Reconstructive Facial Surgery Techniques
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging and Analysis
- Orthopaedic implants and arthroplasty
- Soft Robotics and Applications
Mayo Clinic
2016-2024
WinnMed
2018-2022
Mayo Clinic in Arizona
2017-2022
Baker Heart and Diabetes Institute
2012-2019
University of Dundee
2014-2016
Ninewells Hospital
2016
Summa Health System
2013
University of Washington
2012
Pain and Rehabilitation Medicine
2012
University of Alabama at Birmingham
2008-2010
The purpose of this study is to provide a framework for the development quality assurance (QA) program use in medical 3D printing applications. An interdisciplinary QA team was built with expertise from all aspects printing. A systematic approach established assess accuracy and precision each step during process, including: image data acquisition, segmentation processing, cleaning. Validation printed models performed by qualitative inspection quantitative measurement. latter achieved...
Abstract Background To determine whether virtual surgical planning and three‐dimensional printed cutting guides (3D/VSP) improved radiographic bone union compared to conventional methods (CM) in fibula free flap (FFF) reconstruction of the mandibles. Methods Retrospective study from years 2000–2018 at a tertiary hospital. Osseous was evaluated by radiologist blinded each patient's treatment. Results Two hundred sixty patients who underwent FFF tissue transfer, 28 with VSP 3D guides. Bony not...
Background Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences soluble guanylyl cyclase (sGC) activator BAY 58-2667 on remodeling, independent changes in hemodynamic load, has not been investigated. In present study, we tested hypothesis that NO•-independent sGC inhibits cardiomyocyte hypertrophy vitro. Concomitant impact fibroblast proliferation, and insights into potential mechanisms action, were also sought. Results compared to...
Background New therapeutic targets for cardiac hypertrophy, an independent risk factor heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention the treatment cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent positive inotropy. The impact on hypertrophy (which negatively regulated by cGMP) however has not been investigated. Methods Neonatal rat cardiomyocytes were incubated with angiotensin II (Ang II)...
The purpose of this study was to use three-dimensional (3-D) printing techniques construct liver and brain phantoms having realistic pathologies, anatomic structures, heterogeneous backgrounds. Patient head computed tomography (CT) images were segmented into tissue, vessels, lesion, white gray matter, cerebrospinal fluid (CSF). Stereolithography files each object created imported a commercial 3-D printer. Printing materials assigned after test scans, which showed that the had CT numbers...
The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) in vivo. Little is known however regarding the cardioprotective actions of N-terminal-derived peptide annexin A1, Ac2-26, particularly beyond its anti-necrotic first few hours after ischemic insult. In this study, we tested hypothesis that exogenous Ac2-26 limits injury vitro Firstly, demonstrated...
Advanced visualization of medical image data in the form three-dimensional (3D) printing continues to expand clinical settings and many hospitals have started adapt 3D technologies aid patient care. It is imperative that radiologists other professionals understand multi-step process converting imaging digital files. To educate health care about steps required prepare DICOM for anatomical models, hands-on courses been delivered at Radiological Society North America (RSNA) annual meeting since...
Nitroxyl (HNO) is a redox congener of NO. We now directly compare the antihypertrophic efficacy HNO and NO donors in neonatal rat cardiomyocytes their contributing mechanisms actions this setting. Isopropylamine-NONOate (IPA-NO) elicited concentration-dependent inhibition endothelin-1 (ET1)-induced increases cardiomyocyte size, with similar suppression hypertrophic genes. Antihypertrophic IPA-NO were significantly attenuated by l-cysteine (HNO scavenger), Rp-8-pCTP-cGMPS (cGMP-dependent...
Maxillectomy can commonly be performed through a transoral approach, but maxillectomy defect reconstruction difficult to precisely design, contour, and inset this approach.To evaluate whether the use of virtual surgical planning (VSP) 3-dimensional (3-D) modeling is associated with decrease in requirement lateral rhinotomy (LR) for patients undergoing total partial reconstruction.This retrospective cohort study was conducted among subtotal or microvascular free flap without VSP 3-D at single...
To assess the impact of metal artifact reduction techniques in 3D printing by evaluating image quality and segmentation time both phantom patient studies with dental restorations and/or other implants. An acrylic denture apparatus (Kilgore Typodent, Kilgore International, Coldwater, MI) was set a 20 cm water scanned on single-source CT scanner gantry tilting capacity (SOMATOM Edge, Siemens Healthcare, Forchheim, Germany) under 5 scenerios: (1) Baseline acquisition at 120 kV no tilt, jaw...
In this work, we provide specific clinical examples to demonstrate basic practical techniques involved in image segmentation, computer-aided design, and 3D printing. A step-by-step approach using United States Food Drug Administration cleared software is provided enhance surgical intervention a patient with complex superior sulcus tumor. Furthermore, patient-specific device creation demonstrated dedicated design software. Relevant anatomy for these tasks obtained from CT Digital Imaging...
Background 3D printing-also known as additive manufacturing-has a wide range of applications. Reproduction low-cost, high-fidelity, disease- or patient-specific models presents key developmental area in simulation and education research for complex cranial surgery. Methods Using cadaveric dissections source materials, skull base were created, printed, tested educational value teaching approaches. In this pilot study, assessments made on the printed demonstrating retrosigmoid posterior...
We sought to validate center-specific published medians and estimate the effects of sonologist Doppler measurement techniques on middle cerebral artery (MCA) peak systolic velocity (PSV) values. studied 154 gravidas with normal singletons who underwent MCA PSV at 18 35 weeks' gestation by one three experienced sonologists. Pregnancies complicated a known fetal anomaly (structural or aneuploidy), amniotic fluid volume disturbance, intrauterine growth restriction, multiple gestation,...
Alzheimer's disease prevalence will reach epidemic proportions in coming decades. There is a need for impactful educational materials to help patients, families, medical practitioners, and policy makers understand the nature impact of disease. Defining an effective workflow create such models from existing segmentation tools be valuable contribution creating these patient-specific models.A step-by-step was developed used take patients' Digital Imaging Computing Medicine magnetic resonance...