A5030153573- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Craniofacial Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Neurofibromatosis and Schwannoma Cases
- Anatomy and Medical Technology
- Sinusitis and nasal conditions
- Surgical Simulation and Training
- Trigeminal Neuralgia and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cleft Lip and Palate Research
- Glioma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Bone Tumor Diagnosis and Treatments
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Eye Disorders
- Nasal Surgery and Airway Studies
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- History of Medical Practice
- Facial Trauma and Fracture Management
- Digital Imaging in Medicine
- Vestibular and auditory disorders
- Oral and Maxillofacial Pathology
Mayo Clinic
2018-2025
WinnMed
2018-2025
Mayo Clinic in Florida
2018-2025
Neurological Surgery
2011-2024
University Foundation
2024
Mayo Clinic in Arizona
2018-2023
Albany Medical Center Hospital
2014-2023
Jacksonville College
2018
University of Pittsburgh
2011-2016
University of Florida
2013-2015
Tumor-cell-secreted extracellular vesicles (EVs) can cross the disrupted blood-brain barrier (BBB) into bloodstream. However, in certain gliomas, BBB remains intact, which might limit EVs release. To evaluate ability of tumor-derived to BBB, we used an orthotopic xenotransplant mouse model human glioma-cancer stem cells featuring intact BBB. We demonstrated that all types tumor cells-derived EVs-apoptotic bodies, shedding microvesicles and exosomes-cross be detected peripheral blood,...
OBJECT.: The object of this paper was to describe the surgical anatomy and technical nuances endonasal transcavernous posterior clinoidectomy approach with interdural pituitary transposition report clinical outcome modification.The proposed studied in 10 colored silicon-injected anatomical specimens. medical records 12 patients that underwent removal clinoid(s) technique were reviewed.The natural corridor provided by cavernous sinus is used get access clinoid mobilizing gland an fashion....
Neurosurgical management of cerebellar lesions remains challenging. Thus, it is important to have sound knowledge the microsurgical anatomy cerebellum and dentate nucleus (DN) define different types exposure in a variety surgical interventions.To examine DN from neurosurgical viewpoint using fiber tracking techniques.Ten formalin-fixed human hemispheres were dissected with Ludwig Klingler dissection technique under × 6 40 magnification. Anatomic images created 3-dimensional diffusion tensor...
Abstract Hands‐on dissections using cadaveric tissues for neuroanatomical education are not easily available in many educational institutions due to financial, safety, and ethical factors. Supplementary pedagogical tools, instance, 3D models of anatomical specimens acquired with photogrammetry an efficient alternative democratize the data. The aim this study was describe a technical guideline acquiring realistic anatomic improve teaching learning process neuroanatomy. Seven different sizes,...
Objectives/Hypothesis: Measure the dimensions of nasoseptal (NS) flap and anterior skull base (ASB) defect. Verify whether is sufficient to cover Study anatomy septal artery (SA). Design: Anatomical radiological study. Methods: After endoscopic craniofacial resection, sufficiency ASB defect was assessed. The SA dissected. number branches in pedicle distance between sphenoid ostium were noted. Radiologic study analyzing CT scans 30 patients for comparison among measurements NS performed....
Object Foramen ovale (FO) puncture allows for trigeminal neuralgia treatment, FO electrode placement, and selected biopsy studies. The goals of this study were to demonstrate the anatomical basis complications related puncture, provide landmarks improvement safety, selective lesioning nerve (TN), optimal placement electrodes. Methods Both sides 50 dry skulls studied obtain distances from relevant cranial base references. A total 36 18 formalin-fixed specimens dissected Meckel cave TN...
Carefully tailoring the transclival approach to involved parts of upper, middle, or lower clivus requires a precise understanding focal relationships clivus.To develop an optimal classification and define extra intracranial each clival level.Ten cadaveric heads 10 dry skulls were dissected using surgical microscope endoscope.The is divided into thirds by 2 endocranial landmarks: dural pori abducens nerves meati glossopharyngeal nerves. Useful landmarks exposed in transnasal that aid locating...
<b>Objective</b> Reconstruction of large clival defects after an endoscopic endonasal procedure is challenging. The objective to analyze the morphology, indications, and limitations extended nasoseptal flap, which adds nasal floor inferior meatus mucosa, compared with standard for reconstruction. <b>Design</b> Twenty-seven sides formalin-fixed anatomical specimens 13 computed tomography (CT) scans were used. Under 0-degree visualization, a flap on one side other performed, as well exposure...
ABSTRACT Nowadays, consent to use donor bodies for medical education and research is obtained from the body donors their families before donation. Recently, International Federation of Associations Anatomists (IFAA) published guidelines that could restrict appearance cadaveric images in commercial anatomical resources such as textbooks other educational products. These state must expressly using this purpose. Cadaveric photos drawings made dissections cadavers have been used anatomy atlases...
The lateral transorbital approach (LTOA) has gained increased recognition, but there is still a paucity of data on its effectiveness and advantages compared with the LTOA orbitotomy, herein denoted as orbital wall (LOWA). aim this study was to provide an anatomical reappraisal authors' clinical experience compare 2 approaches orbit middle cranial fossa (MCF). Eight latex-injected cadaveric specimens were used perform LOWA. operative depth each key landmarks measured. Fifty high-resolution...
BACKGROUND: The sellar wall of the sphenoid sinus and its recesses have been previously studied, but their intracranial relationships to diaphragma sellae, tuberculum, clinoid segment internal carotid artery, chiasmatic sulcus, middle process need further definition. OBJECTIVE: To describe these intra- extracranial in anterior wall. METHODS: was studied 132 parasellar areas dry crania. Thirty-eight formalin-fixed/silicone-colored specimens were dissected. After transsphenoidal endoscopic...
Objective This study was aimed to provide a key update the seminal works of Prof. Albert L. Rhoton Jr., MD, with particular attention previously unpublished insights from oral tradition his fellows, recent technological advances including endoscopy, and high-dynamic range (HDR) photodocumentation, and, local improvements in technique, we have developed optimize efficient neuroanatomic study. Methods Two formaldehyde-fixed cadaveric heads were injected colored latex demonstrate step-by-step...
Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of cribriform plate. Although survival excellent with reported 5-year overall (OS) 82%, recurrence frequent and occurs in 40-50% cases. This study investigates characteristics ENB subsequent prognosis patients recurrence.The clinical records all diagnosed as having at tertiary hospital 1 January 1960 to 2020 were retrospectively reviewed. Overall progression-free (PFS) reported.A total 64 out 143...
The aim of this study was to investigate and compare the surgical anatomy two different routes access drain petrous apex (PA) cholesterol granulomas: expanded endonasal approach (EEA) transcanal infracochlear (TICA).Anatomic radiologic study.The EEA TICA PA were performed in 11 anatomic specimens with assistance imaging guidance. categorized into three zones: superior PA, anterior-inferior posterior-inferior PA. maximum drainage window achieved by each calculated using studies specimen.The...
The endoscope is being introduced as an adjuvant to improve visualization of certain areas in open cranial surgery.To describe the endoscopic anatomy common aneurysm sites and compare it with microsurgical anatomy.Pterional, anterior interhemispheric, subtemporal approaches most were examined cadaveric heads under surgical microscope endoscope.The view, particularly angled endoscopes, provides a significant improvement compared microscopic especially for poorly visualized such medial aspect...
Middle fossa surgery is challenging, and reliable surgical landmarks are essential to perform accurate safe surgery. Although many descriptions of the middle components have been published, a clinically practical description this very complex anatomical region lacking. Small structure arrangements in area often not well visualized or accurately demarcated with neuronavigation systems. The objective describe "roadmap" key reference points during help surgeon predict where critical structures...
Human gliomas harbour cancer stem cells (CSCs) that evolve along the course of disease, forming highly heterogeneous subpopulations within tumour mass. These possess self-renewal properties and appear to contribute initiation, metastasis resistance therapy. CSC cultures isolated from surgical samples are considered best preclinical in vitro model for primary human gliomas. However, it is not yet well characterized which extent their biological functional change during passaging serum-free...